STRINGSTRING
BRD3 BRD3 SIRT7 SIRT7 TP53 TP53 FBL FBL GATA1 GATA1 E2F1 E2F1 BAZ1B BAZ1B PTEN PTEN BRD2 BRD2 KBTBD8 KBTBD8 DEK DEK BRDT BRDT MIOS MIOS CHD4 CHD4 NUTM1 NUTM1 TCOF1 TCOF1 MTOR MTOR CCND2 CCND2 DAXX DAXX SRPK1 SRPK1 ALB ALB WDR24 WDR24 JMJD6 JMJD6 PWWP2B PWWP2B CHD8 CHD8 H3F3A H3F3A UBTF UBTF POLR2L POLR2L H3F3C H3F3C SEH1L SEH1L H3F3C-2 H3F3C-2 HIST2H3D HIST2H3D RPS26 RPS26 ATRX ATRX TOP2A TOP2A H3-4 H3-4 LOC100297725 LOC100297725 LOC613345 LOC613345 HIST1H3C HIST1H3C WDR59 WDR59 LOC788077 LOC788077 LOC788077-2 LOC788077-2 LOC788077-3 LOC788077-3 POLR2A POLR2A LOC788077-4 LOC788077-4 BRD4 BRD4 SRPK2 SRPK2 LOC781224 LOC781224
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRD3Bromodomain containing 3. (722 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts a [...] (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (386 aa)
FBLFibrillarin. (322 aa)
GATA1GATA binding protein 1. (413 aa)
E2F1E2F transcription factor 1. (437 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
PTENPhosphatase and tensin homolog. (573 aa)
BRD2Bromodomain-containing protein 2; Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity). (803 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
DEKDEK proto-oncogene. (375 aa)
BRDTBRD4_CDT domain-containing protein. (248 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1912 aa)
NUTM1NUT midline carcinoma family member 1. (1146 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1458 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CCND2G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (289 aa)
DAXXDeath domain associated protein. (748 aa)
SRPK1SRSF protein kinase 1. (645 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
WDR24WD repeat domain 24. (790 aa)
JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (414 aa)
PWWP2BPWWP domain containing 2B. (561 aa)
CHD8Chromodomain helicase DNA binding protein 8. (2303 aa)
H3F3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
UBTFUpstream binding transcription factor. (757 aa)
POLR2LDNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of [...] (67 aa)
H3F3CHistone H3.3C-like; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
SEH1LNucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (360 aa)
H3F3C-2Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
HIST2H3DHistone H3; Belongs to the histone H3 family. (136 aa)
RPS2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
ATRXATRX chromatin remodeler. (2478 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1532 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100297725Histone H3; Belongs to the histone H3 family. (136 aa)
LOC613345Histone domain-containing protein. (136 aa)
HIST1H3CHistone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
WDR59WD repeat domain 59. (993 aa)
LOC788077Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
LOC788077-2Histone H3. (136 aa)
LOC788077-3Histone H3. (136 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
LOC788077-4Histone H3. (136 aa)
BRD4Bromodomain containing 4. (1096 aa)
SRPK2SRSF protein kinase 2. (765 aa)
LOC781224Histone H3; Belongs to the histone H3 family. (136 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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