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UGT1A1 UGT1A1 GSTZ1 GSTZ1 LOC530553 LOC530553 INS INS GSTA1 GSTA1 CYB5R4 CYB5R4 MGST3 MGST3 CYP3A5 CYP3A5 B2M B2M LOC100295687 LOC100295687 AP5M1 AP5M1 HPRT1 HPRT1 EPHX2 EPHX2 GSTM1 GSTM1 UGT2B10 UGT2B10 ALB ALB CYP2E1 CYP2E1 CYB5R1 CYB5R1 LOC100138004 LOC100138004 LOC781988 LOC781988 EPHX1 EPHX1 MGC152010 MGC152010 UGT2A1 UGT2A1 CYP1A1 CYP1A1 CYP1B1 CYP1B1 CYP2B6 CYP2B6 ENSBTAP00000058374 ENSBTAP00000058374 CYB5RL CYB5RL LOC100138908 LOC100138908 GSTM1-2 GSTM1-2 LOC100296421 LOC100296421 GSTP1-2 GSTP1-2 CYB5R3 CYB5R3 ENSBTAP00000060742 ENSBTAP00000060742 CYB5R2 CYB5R2 KRT19 KRT19 CYP3A4 CYP3A4 GSTT1 GSTT1 NR1I3 NR1I3 GSTP1 GSTP1 LOC615303 LOC615303 ADH4 ADH4 SLC35A2 SLC35A2 CYP1A2 CYP1A2 AHR AHR ALDH1A1 ALDH1A1 MGST1 MGST1 ENSBTAP00000071522 ENSBTAP00000071522 NQO1 NQO1 LOC540544 LOC540544
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (445 aa)
LOC530553UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
GSTA1Glutathione S-transferase. (291 aa)
CYB5R4Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (520 aa)
MGST3Microsomal glutathione S-transferase 3; Also functions as a glutathione peroxidase. (164 aa)
CYP3A5Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
LOC100295687Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalysed oxidative inactivation of enzymes. Belongs to the GST superfamily. Mu family. (218 aa)
AP5M1AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. (490 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
EPHX2Epoxide hydrolase 2. (555 aa)
GSTM1Glutathione S-transferase Mu 1; Belongs to the GST superfamily. (218 aa)
UGT2B10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
CYP2E1Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa)
CYB5R1NADH-cytochrome b5 reductase 1; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
LOC100138004UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
LOC781988UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (451 aa)
MGC152010UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
CYP1B1Uncharacterized protein; Belongs to the cytochrome P450 family. (539 aa)
CYP2B6Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ENSBTAP00000058374Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
CYB5RLNADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (314 aa)
LOC100138908UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
GSTM1-2Uncharacterized protein. (266 aa)
LOC100296421UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
GSTP1-2Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (240 aa)
CYB5R3NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (358 aa)
ENSBTAP00000060742UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (486 aa)
CYB5R2Cytochrome b5 reductase 2. (418 aa)
KRT19Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity); Belongs to the intermediate filament family. (399 aa)
CYP3A4Uncharacterized protein. (503 aa)
GSTT1Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity; Belongs to the GST superfamily. Theta family. (240 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (406 aa)
GSTP1Glutathione S-transferase P; Belongs to the GST superfamily. (191 aa)
LOC615303UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
ADH4PKS_ER domain-containing protein. (380 aa)
SLC35A2UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (396 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
AHRUncharacterized protein. (844 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo. (501 aa)
MGST1Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity (By similarity); Belongs to the MAPEG family. (155 aa)
ENSBTAP00000071522UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (494 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (278 aa)
LOC540544UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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