STRINGSTRING
AR AR GSK3B GSK3B INS INS ENSBTAP00000067962 ENSBTAP00000067962 ALPL ALPL BRAF BRAF LOC101906254 LOC101906254 PXDN PXDN KSR1 KSR1 TRIM24 TRIM24 LOC100125266 LOC100125266 FGF2 FGF2 SPOP SPOP CD274 CD274 DEK DEK LOC528262 LOC528262 LOC516378 LOC516378 NANOG NANOG CUL3 CUL3 ALPI ALPI KLF4 KLF4 BRD4 BRD4 RBX1 RBX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARAndrogen receptor. (890 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (492 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
ENSBTAP00000067962Alkaline phosphatase. (506 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
LOC101906254Uncharacterized protein; Belongs to the alkaline phosphatase family. (519 aa)
PXDNPeroxidasin. (1429 aa)
KSR1Kinase suppressor of ras 1. (921 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
LOC100125266Intestinal-type alkaline phosphatase; Belongs to the alkaline phosphatase family. (533 aa)
FGF2Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
SPOPSpeckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] (374 aa)
CD274Programmed cell death-ligand 1. (289 aa)
DEKDEK proto-oncogene. (375 aa)
LOC528262Uncharacterized protein; Belongs to the alkaline phosphatase family. (529 aa)
LOC516378Uncharacterized protein; Belongs to the alkaline phosphatase family. (531 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT [...] (300 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
ALPIAlkaline phosphatase. (533 aa)
KLF4Kruppel like factor 4. (510 aa)
BRD4Bromodomain containing 4. (1096 aa)
RBX1RING-type domain-containing protein. (261 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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