node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA5 | CASP3 | ENSBTAP00000028988 | ENSBTAP00000021099 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.929 |
ANXA5 | EGFR | ENSBTAP00000028988 | ENSBTAP00000070620 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Receptor protein-tyrosine kinase. | 0.791 |
ANXA5 | GLI1 | ENSBTAP00000028988 | ENSBTAP00000008704 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | GLI family zinc finger 1. | 0.483 |
ANXA5 | SHH | ENSBTAP00000028988 | ENSBTAP00000034059 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.498 |
ANXA5 | SMAD3 | ENSBTAP00000028988 | ENSBTAP00000016728 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | Mothers against decapentaplegic homolog. | 0.576 |
CASP3 | ANXA5 | ENSBTAP00000021099 | ENSBTAP00000028988 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | 0.929 |
CASP3 | EGFR | ENSBTAP00000021099 | ENSBTAP00000070620 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Receptor protein-tyrosine kinase. | 0.799 |
CASP3 | GLI1 | ENSBTAP00000021099 | ENSBTAP00000008704 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | GLI family zinc finger 1. | 0.485 |
CASP3 | SHH | ENSBTAP00000021099 | ENSBTAP00000034059 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.606 |
CASP3 | SMAD3 | ENSBTAP00000021099 | ENSBTAP00000016728 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Mothers against decapentaplegic homolog. | 0.720 |
CASP3 | SMO | ENSBTAP00000021099 | ENSBTAP00000017670 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.418 |
EGFR | ANXA5 | ENSBTAP00000070620 | ENSBTAP00000028988 | Receptor protein-tyrosine kinase. | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | 0.791 |
EGFR | CASP3 | ENSBTAP00000070620 | ENSBTAP00000021099 | Receptor protein-tyrosine kinase. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.799 |
EGFR | GLI1 | ENSBTAP00000070620 | ENSBTAP00000008704 | Receptor protein-tyrosine kinase. | GLI family zinc finger 1. | 0.576 |
EGFR | GLI2 | ENSBTAP00000070620 | ENSBTAP00000015510 | Receptor protein-tyrosine kinase. | GLI family zinc finger 2. | 0.433 |
EGFR | SHH | ENSBTAP00000070620 | ENSBTAP00000034059 | Receptor protein-tyrosine kinase. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.656 |
EGFR | SMAD3 | ENSBTAP00000070620 | ENSBTAP00000016728 | Receptor protein-tyrosine kinase. | Mothers against decapentaplegic homolog. | 0.612 |
EGFR | SMO | ENSBTAP00000070620 | ENSBTAP00000017670 | Receptor protein-tyrosine kinase. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.535 |
GLI1 | ANXA5 | ENSBTAP00000008704 | ENSBTAP00000028988 | GLI family zinc finger 1. | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | 0.483 |
GLI1 | CASP3 | ENSBTAP00000008704 | ENSBTAP00000021099 | GLI family zinc finger 1. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.485 |