STRINGSTRING
HAVCR2 HAVCR2 CD69 CD69 IL17A IL17A CD274 CD274 GZMB GZMB TIGIT TIGIT IFNG IFNG LOC786126 LOC786126 LOC508858 LOC508858 CTLA4 CTLA4 CD5 CD5 CD27 CD27 IL6 IL6 IL2 IL2 TNF TNF CD4 CD4 EOMES EOMES CD244 CD244 LAG3 LAG3 CD80 CD80 ENTPD1 ENTPD1 CD86 CD86 GZMB-2 GZMB-2 LOC505326 LOC505326
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CD69Early activation molecule CD69. (199 aa)
IL17AInterleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. (153 aa)
CD274Programmed cell death-ligand 1. (289 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (243 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC786126Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC508858Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (221 aa)
CD5T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. (495 aa)
CD27CD27 molecule. (249 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (333 aa)
CD4CD4 molecule. (446 aa)
EOMESEomesodermin. (701 aa)
CD244CD244 molecule. (423 aa)
LAG3Lymphocyte activating 3. (544 aa)
CD80CD80 molecule. (296 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. (564 aa)
CD86CD86 molecule. (321 aa)
GZMB-2Duodenase-1; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. (251 aa)
LOC505326Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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