STRINGSTRING
FGF2 FGF2 CYP3A4 CYP3A4 OCLN OCLN SLC35A2 SLC35A2 LOC615303 LOC615303 BMP4 BMP4 CYP1A2 CYP1A2 ENSBTAP00000071522 ENSBTAP00000071522 LOC540544 LOC540544 LOC530553 LOC530553 INS INS PAPPA PAPPA LOC100138908 LOC100138908 LOC100296421 LOC100296421 ENSBTAP00000060742 ENSBTAP00000060742 CYP2B6 CYP2B6 UGT2A1 UGT2A1 MGC152010 MGC152010 CYP2D14 CYP2D14 UGT1A1 UGT1A1 CES2 CES2 CYP2C19 CYP2C19 LOC781988 LOC781988 LOC100138004 LOC100138004 UGT2B10 UGT2B10 CYP3A5 CYP3A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
CYP3A4Uncharacterized protein. (503 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
SLC35A2UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (396 aa)
LOC615303UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
ENSBTAP00000071522UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (494 aa)
LOC540544UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
LOC530553UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
PAPPAPappalysin 1. (1632 aa)
LOC100138908UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
LOC100296421UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ENSBTAP00000060742UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (486 aa)
CYP2B6Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
MGC152010UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CYP2D14Cytochrome P450 2D14; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
CES2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (553 aa)
CYP2C19CYP2C19 protein; Belongs to the cytochrome P450 family. (490 aa)
LOC781988UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC100138004UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
UGT2B10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CYP3A5Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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