STRINGSTRING
TSPAN2 TSPAN2 CD68 CD68 CD79A CD79A CD69 CD69 ACTA1 ACTA1 CD82 CD82 CD19 CD19 TSPAN7 TSPAN7 ITGA4 ITGA4 PTPRC PTPRC CD48 CD48 CD37 CD37 B2M B2M GP5 GP5 G5E5G7_BOVIN G5E5G7_BOVIN CD5 CD5 ATP1B3 ATP1B3 GP9 GP9 CD9 CD9 CTSS CTSS TSPAN4 TSPAN4 CD151 CD151 CD40 CD40 IL2 IL2 IGF1R IGF1R IGF2R IGF2R BSG BSG LAMP1 LAMP1 CD6 CD6 CD44 CD44 TSPAN10 TSPAN10 CD79B CD79B CD81 CD81 TSPAN19 TSPAN19 ENSBTAP00000058374 ENSBTAP00000058374 ATP1A1 ATP1A1 CD38 CD38 LAMP2 LAMP2 TSPAN14 TSPAN14 INS INS TSPAN9 TSPAN9 CD22 CD22 CD86 CD86
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSPAN2Tetraspanin. (233 aa)
CD68CD68 molecule. (335 aa)
CD79AB-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] (223 aa)
CD69Early activation molecule CD69. (199 aa)
ACTA1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
CD82Tetraspanin. (357 aa)
CD19CD19 molecule. (568 aa)
TSPAN7Tetraspanin. (249 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
CD48CD48 molecule. (239 aa)
CD37Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. (303 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
GP5Glycoprotein V platelet. (539 aa)
G5E5G7_BOVINTetraspanin. (260 aa)
CD5T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. (495 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
GP9Glycoprotein IX platelet. (180 aa)
CD9CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (226 aa)
CTSSCathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. (331 aa)
TSPAN4Tetraspanin. (311 aa)
CD151CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (509 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
IGF1RInsulin-like growth factor 1 receptor alpha chain; Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates ( [...] (1367 aa)
IGF2RCation-independent mannose-6-phosphate receptor; Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2; Belongs to the MRL1/IGF2R family. (2499 aa)
BSGBasigin. (320 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. (409 aa)
CD6CD6 molecule. (681 aa)
CD44CD44 antigen. (703 aa)
TSPAN10Tetraspanin. (372 aa)
CD79BCD79b molecule. (229 aa)
CD81CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (236 aa)
TSPAN19Tetraspanin. (248 aa)
ENSBTAP00000058374Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1052 aa)
CD38CD38 molecule. (299 aa)
LAMP2Lysosomal associated membrane protein 2. (453 aa)
TSPAN14Tetraspanin. (385 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
TSPAN9Tetraspanin. (330 aa)
CD22CD22 molecule. (928 aa)
CD86CD86 molecule. (321 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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