STRINGSTRING
HAVCR2 HAVCR2 GIMAP7 GIMAP7 SASH3 SASH3 DOCK8 DOCK8 SNX20 SNX20 IL10RA IL10RA CD274 CD274 CD53 CD53 CORO1A CORO1A EVI2B EVI2B PTPRC PTPRC GIMAP7-2 GIMAP7-2 CD37 CD37 TIGIT TIGIT APBB1IP APBB1IP CTLA4 CTLA4 RCSD1 RCSD1 FASN FASN ALB ALB LRAT LRAT IRF8 IRF8 SELPLG SELPLG BTK BTK CYTH4 CYTH4 GIMAP4 GIMAP4 ACTB ACTB CD4 CD4 GIMAP7-3 GIMAP7-3 GIMAP7-4 GIMAP7-4 NCKAP1L NCKAP1L PLAAT1 PLAAT1 ARHGAP15 ARHGAP15 PTGIS PTGIS DOCK2 DOCK2 GAPDH GAPDH LAG3 LAG3 CD74 CD74 BIN2 BIN2 CD80 CD80 EGFR EGFR ALK ALK CD86 CD86
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
GIMAP7AIG1-type G domain-containing protein. (297 aa)
SASH3SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. (380 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2098 aa)
SNX20Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. (316 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
CD274Programmed cell death-ligand 1. (289 aa)
CD53Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). (219 aa)
CORO1ACoronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity); Belongs to the WD repeat coronin family. (461 aa)
EVI2BEcotropic viral integration site 2B. (456 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
GIMAP7-2GTPase, IMAP family member 7. (293 aa)
CD37Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. (303 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (243 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (658 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (221 aa)
RCSD1CapZ-interacting protein; Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. (381 aa)
FASN3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2515 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
LRATLecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodopsin and t [...] (230 aa)
IRF8Interferon regulatory factor 8. (427 aa)
SELPLGSelectin P ligand. (427 aa)
BTKTyrosine-protein kinase. (659 aa)
CYTH4Cytohesin 4. (394 aa)
GIMAP4GTPase, IMAP family member 4. (319 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CD4CD4 molecule. (446 aa)
GIMAP7-3GTPase, IMAP family member 7. (294 aa)
GIMAP7-4AIG1-type G domain-containing protein. (296 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
PLAAT1Phospholipase A and acyltransferase 1. (198 aa)
ARHGAP15Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). (471 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (517 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1868 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (376 aa)
LAG3Lymphocyte activating 3. (544 aa)
CD74CD74 molecule. (268 aa)
BIN2Bridging integrator 2. (519 aa)
CD80CD80 molecule. (296 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
ALKTyrosine-protein kinase receptor. (1451 aa)
CD86CD86 molecule. (321 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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