STRINGSTRING
MAP3K7 MAP3K7 HTT HTT DDX10 DDX10 PHF5A PHF5A DHX15 DHX15 SF3B1 SF3B1 SF3B5 SF3B5 SF3B3 SF3B3 ORAI2 ORAI2 DDX31 DDX31 DDX18 DDX18 F1MSX0_BOVIN F1MSX0_BOVIN HTATSF1-2 HTATSF1-2 SUGP1 SUGP1 TTI1 TTI1 HTATSF1 HTATSF1 U2AF2 U2AF2 DDX46 DDX46
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (632 aa)
HTTHuntingtin. (3078 aa)
DDX10RNA helicase. (876 aa)
PHF5APHD finger protein 5A. (110 aa)
DHX15DEAH-box helicase 15. (795 aa)
SF3B1Splicing factor 3b subunit 1. (1304 aa)
SF3B5Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. (86 aa)
SF3B3Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] (1217 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (254 aa)
DDX31RNA helicase. (736 aa)
DDX18RNA helicase. (670 aa)
F1MSX0_BOVINRNA helicase. (689 aa)
HTATSF1-2HIV-1 Tat specific factor 1. (740 aa)
SUGP1SURP and G-patch domain containing 1. (635 aa)
TTI1TELO2 interacting protein 1. (1092 aa)
HTATSF1Uncharacterized protein. (773 aa)
U2AF2U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
DDX46DEAD-box helicase 46. (1037 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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