STRINGSTRING
CXADR CXADR CCK CCK LAG3 LAG3 TYROBP TYROBP CCR7 CCR7 NKG7 NKG7 GZMB-2 GZMB-2 SLC7A5 SLC7A5 SLC38A1 SLC38A1 CSF2 CSF2 GZMK GZMK CD274 CD274 CD19 CD19 SLC7A8 SLC7A8 GZMB GZMB SLC38A2 SLC38A2 SLC43A2 SLC43A2 IFNG IFNG ULK1 ULK1 BIRC5 BIRC5 IL2 IL2 ANXA5 ANXA5 ACTB ACTB CD4 CD4 SLC7A6 SLC7A6 SLC7A7 SLC7A7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXADRCoxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] (378 aa)
CCKCholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family. (115 aa)
LAG3Lymphocyte activating 3. (544 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (152 aa)
CCR7C-C chemokine receptor type 7; Receptor for the MIP-3-beta chemokine; Belongs to the G-protein coupled receptor 1 family. (415 aa)
NKG7Protein NKG7. (238 aa)
GZMB-2Duodenase-1; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. (251 aa)
SLC7A5Solute carrier family 7 member 5. (617 aa)
SLC38A1Solute carrier family 38 member 1. (486 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (143 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
CD274Programmed cell death-ligand 1. (289 aa)
CD19CD19 molecule. (568 aa)
SLC7A8Solute carrier family 7 member 8. (528 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
SLC38A2Sodium-coupled neutral amino acid transporter 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity). (506 aa)
SLC43A2Large neutral amino acids transporter small subunit 4; Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids. (568 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1034 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
ANXA5Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. (321 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CD4CD4 molecule. (446 aa)
SLC7A6Solute carrier family 7 member 6. (515 aa)
SLC7A7Solute carrier family 7 member 7. (518 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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