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| | DLL3 | Delta like canonical Notch ligand 3. (587 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | EREG | Epiregulin. (163 aa) |
| | FAT4 | FAT atypical cadherin 4. (4982 aa) |
| | NRG3 | Neuregulin 3. (701 aa) |
| | ADAM2 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (745 aa) |
| | OIT3 | Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development. (547 aa) |
| | FBLN7 | Fibulin 7. (439 aa) |
| | CCBE1 | Collagen and calcium binding EGF domains 1. (408 aa) |
| | RSPO3 | R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non- canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts [...] (273 aa) |
| | CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3045 aa) |
| | ADGRE1 | Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (1250 aa) |
| | NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. (570 aa) |
| | THSD7A | Thrombospondin type 1 domain containing 7A. (1676 aa) |
| | F7 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium; Belongs to the peptidase S1 family. (447 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | SELE | E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. (485 aa) |
| | NID1 | NID1 protein. (1241 aa) |
| | PCSK6 | Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (956 aa) |
| | CNTNAP3 | Cell recognition molecule CASPR3. (742 aa) |
| | NRXN2 | Neurexin 2. (1703 aa) |
| | HYAL1 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). (450 aa) |
| | HYAL2 | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family. (473 aa) |
| | TNC | Tenascin C. (2293 aa) |
| | PLAT | Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. (566 aa) |
| | TNXB | Tenascin XB. (4094 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (767 aa) |
| | SCUBE3 | Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa) |
| | NPNT | Nephronectin. (616 aa) |
| | TENM2 | Teneurin transmembrane protein 2. (2654 aa) |
| | RELN | Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3460 aa) |
| | MFGE8 | Lactadherin; Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. (431 aa) |
| | CSPG5 | Chondroitin sulfate proteoglycan 5 (Neuroglycan C). (544 aa) |
| | GPR179 | G protein-coupled receptor 179. (2354 aa) |
| | NCAN | Neurocan. (1347 aa) |
| | SVEP1 | Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3227 aa) |
| | THBS2 | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity); Belongs to the thrombospondin family. (1170 aa) |
| | FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa) |
| | HYAL3 | Hyaluronidase. (419 aa) |
| | EFEMP2 | EGF containing fibulin extracellular matrix protein 2. (450 aa) |
| | ADAM22 | ADAM metallopeptidase domain 22. (930 aa) |
| | MEGF10 | Multiple EGF like domains 10. (1136 aa) |
| | CNTNAP5 | Contactin associated protein like 5. (1307 aa) |
| | LOC527981 | Uncharacterized protein. (1912 aa) |
| | PROS1 | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. (676 aa) |
| | MEGF6 | Multiple EGF like domains 6. (1760 aa) |
| | MEGF8 | Multiple EGF like domains 8. (2810 aa) |
| | NTNG1 | Netrin G1. (582 aa) |
| | ENSBTAP00000068773 | EGF-like domain-containing protein. (208 aa) |
| | ENSBTAP00000068667 | VWFC domain-containing protein. (506 aa) |
| | ADAM28 | ADAM metallopeptidase domain 28. (755 aa) |
| | VWA2 | Von Willebrand factor A domain containing 2. (872 aa) |
| | ATRNL1 | Attractin like 1. (1381 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa) |
| | VCAN | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3381 aa) |
| | LRP1B | LDL receptor related protein 1B. (4514 aa) |
| | VLDLR | Very low density lipoprotein receptor. (873 aa) |
| | ADGRE5 | CD97 antigen; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity); Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (832 aa) |
| | PROZ | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. (490 aa) |
| | AGRN | Agrin. (2068 aa) |
| | LTBP3 | Latent transforming growth factor beta binding protein 3. (1297 aa) |
| | LRP8 | LDL receptor related protein 8. (1014 aa) |
| | ADAM23 | ADAM metallopeptidase domain 23. (838 aa) |
| | TENM3 | Teneurin transmembrane protein 3. (2550 aa) |
| | MUC4 | Mucin 4, cell surface associated. (2613 aa) |
| | ENSBTAP00000058488 | Uncharacterized protein. (433 aa) |
| | ENSBTAP00000058403 | Uncharacterized protein. (268 aa) |
| | NRG4 | Neuregulin 4. (116 aa) |
| | FBN3 | Fibrillin 3. (2801 aa) |
| | FAT1 | FAT atypical cadherin 1. (4643 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (866 aa) |
| | NTNG2 | NTNG2 protein. (531 aa) |
| | NRG2 | Neuregulin 2. (853 aa) |
| | VASN | VASN protein. (673 aa) |
| | LTBP4 | Latent transforming growth factor beta binding protein 4. (1623 aa) |
| | LOC101906048 | Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (181 aa) |
| | CRELD2 | Protein disulfide isomerase CRELD2; Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity); Belongs to the CRELD family. (351 aa) |
| | ITGBL1 | Integrin subunit beta like 1. (496 aa) |
| | CD248 | CD248 molecule. (776 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | SLIT2 | Slit guidance ligand 2. (1534 aa) |
| | FAT2 | FAT atypical cadherin 2. (4347 aa) |
| | SLIT1 | Slit guidance ligand 1. (1534 aa) |
| | NRXN1 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] (852 aa) |
| | NOTCH3 | Notch receptor 3. (2332 aa) |
| | ASTN1 | Astrotactin 1. (1303 aa) |
| | LOC527125 | Hyaluronidase. (489 aa) |
| | ADAM20 | ADAM metallopeptidase domain 20. (723 aa) |
| | CD93 | CD93 molecule. (648 aa) |
| | E1B7I3_BOVIN | Uncharacterized protein. (745 aa) |
| | ADAM3A | Uncharacterized protein. (737 aa) |
| | F9 | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (447 aa) |
| | NOTCH4 | Notch receptor 4. (1989 aa) |
| | SLIT3 | Slit guidance ligand 3. (1475 aa) |
| | MEP1B | Meprin A subunit. (700 aa) |
| | NRG1 | Neuregulin 1. (701 aa) |
| | TECTA | Tectorin alpha. (2146 aa) |
| | SELL | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (399 aa) |
| | NELL2 | Protein kinase C-binding protein NELL2. (816 aa) |
| | ATRAID | All-trans retinoic acid induced differentiation factor. (229 aa) |
| | ZAN | Zonadhesin (gene/pseudogene). (2459 aa) |
| | LRP4 | Low density lipoprotein receptor-related protein 4. (1905 aa) |
| | SUSD1 | Sushi domain containing 1. (753 aa) |
| | UMODL1 | Uromodulin like 1. (1394 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1281 aa) |
| | MATN1 | Matrilin 1. (497 aa) |
| | EGFL7 | EGF like domain multiple 7. (284 aa) |
| | ATRN | Attractin. (1415 aa) |
| | HYAL4 | Hyaluronidase. (481 aa) |
| | DLK2 | Protein delta homolog 2; Regulates adipogenesis. (383 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa) |
| | STAB2 | Stabilin 2. (2549 aa) |
| | CLEC14A | C-type lectin domain family 14, member A. (490 aa) |
| | CLEC18C | MRCL protein. (624 aa) |
| | COMP | Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (756 aa) |
| | LRP2 | LDL receptor related protein 2. (4622 aa) |
| | EGFL8 | EGF like domain multiple 8. (295 aa) |
| | MEP1A | Meprin A subunit. (717 aa) |
| | BTC | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). (178 aa) |
| | FAT3 | FAT atypical cadherin 3. (4555 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | TGFA | Transforming growth factor alpha. (228 aa) |
| | THBD | Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. (637 aa) |
| | DLK1 | Delta like non-canonical Notch ligand 1. (383 aa) |
| | CUBN | Cubilin. (3620 aa) |
| | SCUBE1 | Signal peptide, CUB domain and EGF like domain containing 1. (1018 aa) |
| | TENM1 | Teneurin transmembrane protein 1. (2713 aa) |
| | MEGF11 | Multiple EGF like domains 11. (1062 aa) |
| | CNTNAP4 | Contactin associated protein like 4. (1308 aa) |
| | THBS4 | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] (961 aa) |
| | GAS6 | Growth arrest specific 6. (671 aa) |
| | PEAR1 | Platelet endothelial aggregation receptor 1. (1040 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1407 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (839 aa) |
| | TMEFF1 | Uncharacterized protein. (378 aa) |
| | LTBP2 | Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family. (1963 aa) |
| | NID2 | Nidogen 2. (1304 aa) |
| | CELSR3 | Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3313 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (208 aa) |
| | VWCE | Von Willebrand factor C and EGF domains. (951 aa) |
| | HEG1 | Heart development protein with EGF like domains 1. (1471 aa) |
| | TDGF1 | Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (181 aa) |
| | MATN3 | Matrilin 3. (421 aa) |
| | SELP | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family. (646 aa) |
| | SCUBE2 | Signal peptide, CUB domain and EGF like domain containing 2. (1027 aa) |
| | LOC100300051 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (806 aa) |
| | NRXN3 | Neurexin-3-beta. (868 aa) |
| | TEK | Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angi [...] (1125 aa) |
| | LTBP1 | Latent transforming growth factor beta binding protein 1. (1708 aa) |
| | ADGRL4 | Adhesion G protein-coupled receptor L4; Belongs to the G-protein coupled receptor 2 family. (689 aa) |
| | EGFLAM | Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). (1059 aa) |
| | SCARF2 | Scavenger receptor class F member 2. (838 aa) |
| | HABP2 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. (558 aa) |
| | CNTNAP1 | Contactin associated protein 1. (1388 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (603 aa) |
| | CELSR2 | Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2920 aa) |
| | AREG | Amphiregulin. (247 aa) |
| | EGFL6 | EGF like domain multiple 6. (515 aa) |
| | HGFAC | HGF activator. (651 aa) |
| | MATN2 | MATN2 protein. (958 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4356 aa) |
| | TENM4 | Teneurin transmembrane protein 4. (2891 aa) |
| | PROC | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (459 aa) |
| | TMEM8A | Transmembrane protein 8A. (764 aa) |
| | F10 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. (608 aa) |
| | C9 | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. (548 aa) |
| | HHIP | Hedgehog interacting protein. (700 aa) |
| | DNER | Delta/notch like EGF repeat containing. (727 aa) |
| | TNN | Tenascin N. (1296 aa) |
| | ADAM33 | ADAM metallopeptidase domain 33. (778 aa) |
| | FBLN2 | Fibulin 2. (1207 aa) |
| | THBS3 | Thrombospondin 3. (956 aa) |
| | THBS1 | Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity); Belongs to the thrombospondin family. (1175 aa) |
| | ADAM11 | ADAM metallopeptidase domain 11. (812 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | FBN2 | Fibrillin 2. (2912 aa) |
| | TMEFF2 | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity); Belongs to the tomoregulin family. (374 aa) |
| | STAB1 | Stabilin 1. (2568 aa) |
| | WIF1 | WNT inhibitory factor 1. (379 aa) |
| | SORL1 | Sortilin related receptor 1. (2211 aa) |
| | SNED1 | Sushi, nidogen and EGF like domains 1. (1361 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | ITGB5 | Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (800 aa) |
| | BRINP2 | BMP/retinoic acid inducible neural specific 2. (784 aa) |
| | NOTCH1 | Notch receptor 1. (2533 aa) |
| | LRP1 | LDL receptor related protein 1. (4545 aa) |
| | BCAN | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. (912 aa) |
| | FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2990 aa) |
| | MMRN1 | Multimerin 1. (1217 aa) |
| | TIE1 | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1139 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (821 aa) |
| | ADAM32 | ADAM metallopeptidase domain 32. (764 aa) |
| | ENSBTAP00000062008 | Uncharacterized protein. (2120 aa) |
| | NELL1 | Uncharacterized protein. (417 aa) |
| | UMOD | Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. (647 aa) |
| | EDIL3 | EGF like repeats and discoidin domains 3. (480 aa) |
| | PAMR1 | Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle. Belongs to the peptidase S1 family. (720 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (845 aa) |
| | SCARF1 | Scavenger receptor class F member 1. (932 aa) |
| | TMEM8B | Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity); Belongs to the TMEM8 family. (930 aa) |
| | MATN4 | Matrilin 4. (584 aa) |
| | CRELD1 | Protein disulfide isomerase CRELD1; Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). (469 aa) |
