(19 nodes) Guanine nucleotide exchange factor for Ras-like GTPases network (Bos taurus)

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Your Input:
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1265 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (927 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] (1648 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	RASGEF1B	Ras-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). (472 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (884 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1257 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator-like 2. (779 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	RGL3	Ral guanine nucleotide dissociation stimulator like 3. (727 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1240 aa)
	RASGRP2	RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. (610 aa)
	RAPGEF6	Uncharacterized protein. (1617 aa)
	RGL1	Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
	RALGDS	Uncharacterized protein. (852 aa)
	RASGRP3	RAS guanyl releasing protein 3. (697 aa)
	RASGEF1A	RasGEF domain family member 1A. (508 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RAPGEF1	RAPGEF2	ENSBTAP00000060297	ENSBTAP00000057535	Rap guanine nucleotide exchange factor 1.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.406
RAPGEF2	RAPGEF1	ENSBTAP00000057535	ENSBTAP00000060297	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Rap guanine nucleotide exchange factor 1.	0.406
RAPGEF2	RAPGEF6	ENSBTAP00000057535	ENSBTAP00000000910	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Uncharacterized protein.	0.952
RAPGEF2	RASGEF1A	ENSBTAP00000057535	ENSBTAP00000061902	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	RasGEF domain family member 1A.	0.442
RAPGEF2	RASGRF2	ENSBTAP00000057535	ENSBTAP00000072047	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Ras protein specific guanine nucleotide releasing factor 2.	0.521
RAPGEF2	RASGRP1	ENSBTAP00000057535	ENSBTAP00000029159	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	RAS guanyl releasing protein 1.	0.524
RAPGEF3	RAPGEF4	ENSBTAP00000058287	ENSBTAP00000053320	Rap guanine nucleotide exchange factor 3.	Rap guanine nucleotide exchange factor 4.	0.906
RAPGEF4	RAPGEF3	ENSBTAP00000053320	ENSBTAP00000058287	Rap guanine nucleotide exchange factor 4.	Rap guanine nucleotide exchange factor 3.	0.906
RAPGEF6	RAPGEF2	ENSBTAP00000000910	ENSBTAP00000057535	Uncharacterized protein.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.952
RASGEF1A	RAPGEF2	ENSBTAP00000061902	ENSBTAP00000057535	RasGEF domain family member 1A.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.442
RASGEF1A	RASGRF2	ENSBTAP00000061902	ENSBTAP00000072047	RasGEF domain family member 1A.	Ras protein specific guanine nucleotide releasing factor 2.	0.446
RASGEF1A	RASGRP1	ENSBTAP00000061902	ENSBTAP00000029159	RasGEF domain family member 1A.	RAS guanyl releasing protein 1.	0.468
RASGRF1	RASGRF2	ENSBTAP00000026564	ENSBTAP00000072047	Ras protein specific guanine nucleotide releasing factor 1.	Ras protein specific guanine nucleotide releasing factor 2.	0.903
RASGRF2	RAPGEF2	ENSBTAP00000072047	ENSBTAP00000057535	Ras protein specific guanine nucleotide releasing factor 2.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.521
RASGRF2	RASGEF1A	ENSBTAP00000072047	ENSBTAP00000061902	Ras protein specific guanine nucleotide releasing factor 2.	RasGEF domain family member 1A.	0.446
RASGRF2	RASGRF1	ENSBTAP00000072047	ENSBTAP00000026564	Ras protein specific guanine nucleotide releasing factor 2.	Ras protein specific guanine nucleotide releasing factor 1.	0.903
RASGRF2	RASGRP1	ENSBTAP00000072047	ENSBTAP00000029159	Ras protein specific guanine nucleotide releasing factor 2.	RAS guanyl releasing protein 1.	0.527
RASGRF2	SOS1	ENSBTAP00000072047	ENSBTAP00000015471	Ras protein specific guanine nucleotide releasing factor 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.541
RASGRP1	RAPGEF2	ENSBTAP00000029159	ENSBTAP00000057535	RAS guanyl releasing protein 1.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.524
RASGRP1	RASGEF1A	ENSBTAP00000029159	ENSBTAP00000061902	RAS guanyl releasing protein 1.	RasGEF domain family member 1A.	0.468

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