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GSTP1 | Glutathione S-transferase P; Belongs to the GST superfamily. (191 aa) | ||||
CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa) | ||||
AKR1A1 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detox [...] (325 aa) | ||||
MGC127055 | Uncharacterized protein MGC127055; Belongs to the cytochrome P450 family. (500 aa) | ||||
CYP20A1 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. (462 aa) | ||||
NAA20 | N(alpha)-acetyltransferase 20, NatB catalytic subunit. (178 aa) | ||||
SULT1B1 | Sulfotransferase family cytosolic 1B member 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine (By s [...] (296 aa) | ||||
AKR1B10 | Aldo_ket_red domain-containing protein. (310 aa) | ||||
AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) | ||||
CYP51A1 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (502 aa) | ||||
CYP4V2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (527 aa) | ||||
CYP24A1 | Uncharacterized protein. (447 aa) | ||||
GAL3ST3 | Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity); Belongs to the galactose-3-O-sulfotransferase family. (427 aa) | ||||
SULT1C2 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa) | ||||
SULT1C3 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (304 aa) | ||||
FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) | ||||
NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit. (237 aa) | ||||
GSS | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. (474 aa) | ||||
CYP39A1 | CYP39A1 protein; Belongs to the cytochrome P450 family. (469 aa) | ||||
CHST1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa) | ||||
GSTO2 | Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa) | ||||
CHST14 | Carbohydrate sulfotransferase. (376 aa) | ||||
GSTO1 | Uncharacterized protein; Belongs to the GST superfamily. (241 aa) | ||||
CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa) | ||||
GSTT1 | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity; Belongs to the GST superfamily. Theta family. (240 aa) | ||||
SULT4A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (284 aa) | ||||
CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa) | ||||
GSR | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa) | ||||
NDST3 | N-deacetylase and N-sulfotransferase 3. (522 aa) | ||||
HS3ST1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (312 aa) | ||||
CHST7 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (486 aa) | ||||
MGST1 | Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity (By similarity); Belongs to the MAPEG family. (155 aa) | ||||
SULT1A1 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity). (295 aa) | ||||
SULT6B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (303 aa) | ||||
CHST13 | Carbohydrate sulfotransferase. (340 aa) | ||||
GAL3ST2 | Galactose-3-O-sulfotransferase 2. (397 aa) | ||||
GSTK1 | Glutathione S-transferase kappa. (226 aa) | ||||
MGST3 | Microsomal glutathione S-transferase 3; Also functions as a glutathione peroxidase. (164 aa) | ||||
CHST11 | Carbohydrate sulfotransferase. (352 aa) | ||||
FMO5 | Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa) | ||||
SULT1E1 | Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). (295 aa) | ||||
CYP4B1 | Cytochrome P450, family 4, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (511 aa) | ||||
CYP26B1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] (512 aa) | ||||
AKR7A2 | Aldo_ket_red domain-containing protein. (369 aa) | ||||
NDST1 | N-deacetylase and N-sulfotransferase 1. (882 aa) | ||||
NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (883 aa) | ||||
CYP2U1 | Cytochrome P450 2U1; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate [...] (543 aa) | ||||
NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit. (359 aa) | ||||
CYP27A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (537 aa) | ||||
GSTCD | Glutathione S-transferase C-terminal domain-containing protein. (631 aa) | ||||
HNMT | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine; Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. (292 aa) | ||||
CYP19A1 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] (503 aa) | ||||
KCNAB3 | Potassium voltage-gated channel, shaker-related subfamily, beta member 3. (404 aa) | ||||
GAL3ST4 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta- 1,6)GalNAc (By similarity); Belongs to the galactose-3-O-sulfotransferase family. (483 aa) | ||||
EPHX2 | Epoxide hydrolase 2. (555 aa) | ||||
CYP4X1 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (471 aa) | ||||
FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (550 aa) | ||||
NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa) | ||||
CYP27B1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa) | ||||
CHST4 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (391 aa) | ||||
HS3ST2 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (367 aa) | ||||
LOC782061-2 | AKR1C4 protein. (323 aa) | ||||
CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (493 aa) | ||||
CYP2S1 | CYP2S1 protein; Belongs to the cytochrome P450 family. (494 aa) | ||||
CYP2E1 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa) | ||||
NAT14 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity). Belongs to the camello family. (206 aa) | ||||
HS3ST6 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (342 aa) | ||||
TPMT | Thiopurine S-methyltransferase. (245 aa) | ||||
COMT | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. (435 aa) | ||||
FMO3 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] (532 aa) | ||||
CYP26A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa) | ||||
MGST2 | Microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione (By similarity); Belongs to the MAPEG family. (146 aa) | ||||
NAA50 | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] (169 aa) | ||||
LOC514658 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (286 aa) | ||||
LOC509506 | Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa) | ||||
LOC530653 | Uncharacterized protein. (484 aa) | ||||
UGT1A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa) | ||||
LOC788425 | Aldo_ket_red domain-containing protein. (334 aa) | ||||
GLYATL2 | Glycine-N-acyltransferase like 2. (375 aa) | ||||
HS3ST3A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (405 aa) | ||||
CHST2 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (527 aa) | ||||
KCNAB2 | Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore- forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarit [...] (415 aa) | ||||
GSTA2 | Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (223 aa) | ||||
CYP8B1 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (166 aa) | ||||
NAT1 | Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. (290 aa) | ||||
HS6ST3 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (473 aa) | ||||
CHST6 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (395 aa) | ||||
CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa) | ||||
UGT2A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa) | ||||
CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa) | ||||
GPX3 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (226 aa) | ||||
CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa) | ||||
CYP21 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (496 aa) | ||||
LOC540707 | Cytochrome P450 2A; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (450 aa) | ||||
KCNAB1 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] (408 aa) | ||||
LOC534967 | Uncharacterized protein. (1037 aa) | ||||
SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (338 aa) | ||||
NDST4 | N-deacetylase and N-sulfotransferase 4. (872 aa) | ||||
CHST8 | Carbohydrate sulfotransferase. (424 aa) | ||||
CYP1B1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (539 aa) | ||||
CHST9 | Carbohydrate sulfotransferase. (442 aa) | ||||
CYP2B6 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) | ||||
GSTM3 | Glutathione S-transferase. (240 aa) | ||||
GSTA4 | Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (303 aa) | ||||
GAL3ST1 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3- galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1- alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity). (423 aa) | ||||
CHST10 | Carbohydrate sulfotransferase. (367 aa) | ||||
CHST3 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (479 aa) | ||||
CHST12 | Carbohydrate sulfotransferase. (451 aa) | ||||
HS2ST1 | Uncharacterized protein. (371 aa) | ||||
CYP46A1 | Cytochrome P450, family 46, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (501 aa) | ||||
FMO1 | Flavin-containing monooxygenase. (612 aa) | ||||
CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (446 aa) | ||||
EPHX1 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (451 aa) | ||||
CYP2R1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (471 aa) | ||||
SULT1C4-2 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (306 aa) | ||||
GLYAT | Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. (377 aa) |