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RPLP1 RPLP1 RPS17 RPS17 RPL14 RPL14 RPL19 RPL19 RPS28 RPS28 MRPL19 MRPL19 RPS3 RPS3 RPL23 RPL23 RPL4 RPL4 RPL27A RPL27A RPS9 RPS9 UBA52 UBA52 RPS6KB2 RPS6KB2 RPS2 RPS2 RPS3A RPS3A RPL7A RPL7A RPL26 RPL26 RPS23 RPS23 RPL24 RPL24 RPS27 RPS27 RPS11 RPS11 RPL32 RPL32 RPS10 RPS10 RPS5 RPS5 RPS6KB1 RPS6KB1 RPS6KA3 RPS6KA3 RPL29 RPL29 RPS4X RPS4X RPS20 RPS20 RPL10A RPL10A RPS15 RPS15 RPL7 RPL7 RPS15A RPS15A RPL11 RPL11 RPL28 RPL28 RPL13 RPL13 RPL39-2 RPL39-2 RPLP0 RPLP0 RPL35A-2 RPL35A-2 RPS19-2 RPS19-2 RPL30-2 RPL30-2 RPS6KA2 RPS6KA2 RPS8 RPS8 RPS14 RPS14 RPS24 RPS24 RPS6KA6 RPS6KA6 RPL22 RPL22 RPS18 RPS18 RPS7 RPS7 RPL34 RPL34 RPS27A-2 RPS27A-2 RPL3L RPL3L RPL35 RPL35 RPS12 RPS12 RPS6KA1 RPS6KA1 RPSA RPSA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPLP160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
RPS1740S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family. (205 aa)
RPL1460S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family. (213 aa)
RPL1960S ribosomal protein L19. (196 aa)
RPS2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
MRPL1939S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family. (292 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
RPL2360S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. (140 aa)
RPL460S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (422 aa)
RPL27A60S ribosomal protein L27a. (148 aa)
RPS940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
RPS240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (309 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPL7A60S ribosomal protein L7a. (266 aa)
RPL2660S ribosomal protein L26. (145 aa)
RPS2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
RPL2460S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
RPS1140S ribosomal protein S11. (158 aa)
RPL3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
RPS1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
RPS540S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. (204 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (525 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
RPL2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (152 aa)
RPS4X40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPS2040S ribosomal protein S20. (119 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. (217 aa)
RPS1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
RPL760S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (248 aa)
RPS15A40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (168 aa)
RPL2860S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (208 aa)
RPL1360S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (293 aa)
RPL39-260S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
RPL35A-260S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). (110 aa)
RPS19-240S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
RPL30-260S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family. (115 aa)
RPS6KA2Ribosomal protein S6 kinase. (759 aa)
RPS840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (257 aa)
RPS14Uncharacterized protein. (165 aa)
RPS2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. (131 aa)
RPS6KA6Ribosomal protein S6 kinase. (835 aa)
RPL22Uncharacterized protein. (129 aa)
RPS1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA; Belongs to the universal ribosomal protein uS13 family. (168 aa)
RPS740S ribosomal protein S7; Required for rRNA maturation. (261 aa)
RPL34Ribosomal protein L34. (117 aa)
RPS27A-2Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (141 aa)
RPL3L60S ribosomal protein L3-like; Belongs to the universal ribosomal protein uL3 family. (449 aa)
RPL3560S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family. (159 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (229 aa)
RPS6KA1Ribosomal protein S6 kinase. (747 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (315 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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