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CYP4A22 CYP4A22 HADH HADH ACAT2 ACAT2 ADH4 ADH4 ACADVL ACADVL ADH6 ADH6 ALDH2 ALDH2 ACSBG2-2 ACSBG2-2 ECI1 ECI1 ACADL ACADL ACAT1 ACAT1 CPT2 CPT2 ADH5 ADH5 CPT1B CPT1B LOC784417 LOC784417 ACSL3 ACSL3 ACADSB ACADSB ACAA1 ACAA1 ALDH1B1 ALDH1B1 ACADM ACADM ALDH9A1 ALDH9A1 ACOX3 ACOX3 CYP4A11 CYP4A11 ALDH7A1 ALDH7A1 ACSL4 ACSL4 EHHADH EHHADH ACSL5 ACSL5 CPT1A CPT1A ACSBG1 ACSBG1 ALDH3A2 ALDH3A2 GCDH GCDH ECI2 ECI2 ACSL1 ACSL1 ACSL6 ACSL6 CPT1C CPT1C ACOX1 ACOX1 HADHB HADHB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CYP4A22CYP4A22 protein; Belongs to the cytochrome P450 family. (515 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
ACAT2Acetyl-Coenzyme A acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ADH4PKS_ER domain-containing protein. (380 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family. (655 aa)
ADH6Uncharacterized protein. (375 aa)
ALDH2Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. (520 aa)
ACSBG2-2AMP-binding domain-containing protein. (269 aa)
ECI1Enoyl-CoA delta isomerase 1. (303 aa)
ACADLAcyl-Coenzyme A dehydrogenase, long chain. (430 aa)
ACAT1Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (422 aa)
CPT2Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
ADH5Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform. (771 aa)
LOC784417Uncharacterized protein; Belongs to the cytochrome P450 family. (521 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
ACADSBShort/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). (432 aa)
ACAA1Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
ALDH1B1Aldehyde dehydrogenase X, mitochondrial; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes. (514 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (421 aa)
ALDH9A14-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. (520 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
CYP4A11Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa)
ALDH7A1Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. (539 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (734 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
ACSL5Acyl-CoA synthetase long-chain family member 5. (683 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ACSBG1Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. (751 aa)
ALDH3A2Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa)
GCDHGlutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity). (458 aa)
ECI2Enoyl-CoA delta isomerase 2. (454 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (728 aa)
ACSL6Acyl-CoA synthetase long chain family member 6. (722 aa)
CPT1CCarnitine palmitoyltransferase 1C. (811 aa)
ACOX1Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (660 aa)
HADHBTrifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] (486 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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