STRINGSTRING
DIS3L DIS3L TOB1 TOB1 LSM1 LSM1 DCP1B DCP1B DCPS DCPS TENT4A TENT4A CNOT9 CNOT9 LSM7 LSM7 CNOT10 CNOT10 EXOSC9 EXOSC9 SKIV2L SKIV2L LSM2 LSM2 DHX36 DHX36 LSM3 LSM3 LSM4 LSM4 PNPT1 PNPT1 DDX6 DDX6 MPHOSPH6 MPHOSPH6 DCP1A DCP1A ENO2 ENO2 XRN2 XRN2 HSPA9 HSPA9 XRN1 XRN1 EXOSC8 EXOSC8 CNOT8 CNOT8 HSPD1 HSPD1 LSM8 LSM8 EXOSC1 EXOSC1 ENO1 ENO1 EXOSC4 EXOSC4 CNOT3 CNOT3 TOB2 TOB2 PNLDC1 PNLDC1 BTG2 BTG2 EXOSC5 EXOSC5 PABPC4 PABPC4 CNOT6 CNOT6 CNOT7 CNOT7 EXOSC7 EXOSC7 BTG3 BTG3 NUDT16 NUDT16 EXOSC3 EXOSC3 DIS3 DIS3 PABPC5 PABPC5 CNOT1 CNOT1 ZCCHC7 ZCCHC7 TTC37 TTC37 ENO4 ENO4 MTREX MTREX BTG4 BTG4 EXOSC10 EXOSC10 PFKL PFKL PAN2 PAN2 PABPC1L2A PABPC1L2A DCP2 DCP2 PABPC1L2A-2 PABPC1L2A-2 PABPC1 PABPC1 TENT4B TENT4B PABPC4L PABPC4L PATL1 PATL1 C1D C1D PABPC1L-2 PABPC1L-2 BTG1 BTG1 LSM6 LSM6 ENO3 ENO3 EDC3 EDC3 EDC4 EDC4 PARN PARN PFKM PFKM CNOT6L CNOT6L EXOSC2 EXOSC2 WDR61 WDR61 EXOSC6 EXOSC6
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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DIS3LDIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. (1053 aa)
TOB1Transducer of ERBB2, 1. (341 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). (133 aa)
DCP1BmRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). (581 aa)
DCPSm7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydro [...] (337 aa)
TENT4ATerminal nucleotidyltransferase 4A. (614 aa)
CNOT9CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] (299 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (743 aa)
EXOSC9Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] (440 aa)
SKIV2LSki2 like RNA helicase. (1246 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
DHX36ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...] (1010 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
MPHOSPH6M-phase phosphoprotein 6. (160 aa)
DCP1ADecapping mRNA 1A. (579 aa)
ENO2ENO2 protein. (434 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (951 aa)
HSPA9Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis probably via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. (679 aa)
XRN15'-3' exoribonuclease 1. (1703 aa)
EXOSC8Exosome complex component RRP43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] (276 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
EXOSC1Exosomal core protein CSL4. (195 aa)
ENO1Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). (500 aa)
EXOSC4Exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] (245 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (744 aa)
TOB2Transducer of ERBB2, 2. (345 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (529 aa)
BTG2BTG anti-proliferation factor 2. (150 aa)
EXOSC5Exosome component 5. (235 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (645 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
CNOT7CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] (285 aa)
EXOSC7Exosome component 7. (291 aa)
BTG3BTG anti-proliferation factor 3. (252 aa)
NUDT16U8 snoRNA-decapping enzyme; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less [...] (201 aa)
EXOSC3Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] (275 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
PABPC5Poly(A) binding protein cytoplasmic 5. (382 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
ZCCHC7Zinc finger CCHC domain-containing protein 7. (546 aa)
TTC37Tetratricopeptide repeat domain 37. (1563 aa)
ENO4Enolase 4. (613 aa)
MTREXMtr4 exosome RNA helicase. (1040 aa)
BTG4BTG anti-proliferation factor 4. (222 aa)
EXOSC10Exosome component 10. (702 aa)
PFKLATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Belongs to the phosphofructokinase typ [...] (780 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
PABPC1L2AUncharacterized protein. (210 aa)
DCP2Decapping mRNA 2. (423 aa)
PABPC1L2A-2Uncharacterized protein. (213 aa)
PABPC1Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] (636 aa)
TENT4BTerminal nucleotidyltransferase 4B. (666 aa)
PABPC4LPoly(A) binding protein cytoplasmic 4 like. (370 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (806 aa)
C1DNuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity); Belongs to the C1D family. (141 aa)
PABPC1L-2PABC domain-containing protein. (183 aa)
BTG1Protein BTG1; Anti-proliferative protein; Belongs to the BTG family. (378 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (101 aa)
ENO3Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. (576 aa)
EDC3Enhancer of mRNA decapping 3. (508 aa)
EDC4Enhancer of mRNA decapping 4. (1429 aa)
PARNPoly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich ele [...] (662 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
CNOT6LEndo/exonuclease/phosphatase domain-containing protein. (555 aa)
EXOSC2Exosome complex component RRP4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytop [...] (293 aa)
WDR61WD repeat-containing protein 61, N-terminally processed. (323 aa)
EXOSC6EXOSC6 protein. (272 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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