STRINGSTRING
TNFSF13 TNFSF13 CXCR4 CXCR4 CCL28 CCL28 BOLA-DYA BOLA-DYA BOLA-DQB BOLA-DQB CCL25 CCL25 BOLA-DOA BOLA-DOA MAP3K14 MAP3K14 ITGA4 ITGA4 BOLA-DRA BOLA-DRA BOLA-DMB BOLA-DMB BOLA-DRB3 BOLA-DRB3 BOLA-DQA5 BOLA-DQA5 ICOSLG ICOSLG IL6 IL6 LOC100848815 LOC100848815 TNFRSF13B TNFRSF13B LTBR LTBR BOLA-DMA BOLA-DMA IL4 IL4 LOC112445051 LOC112445051 AICDA AICDA ITGB7 ITGB7 CCR10 CCR10 BLA-DQB BLA-DQB PIGR PIGR CD40 CD40 IL2 IL2 ICOS ICOS BOLA-DQA2 BOLA-DQA2 TNFRSF13C TNFRSF13C IL5 IL5 E1BCU0_BOVIN E1BCU0_BOVIN LOC100300510 LOC100300510 BOLA-DYB BOLA-DYB TNFSF13B TNFSF13B BOLA-DOB BOLA-DOB LOC100300716 LOC100300716 LOC100296565 LOC100296565 CCR9 CCR9 IL10 IL10 ENSBTAP00000059753 ENSBTAP00000059753 IL15 IL15 BOLA-DRB2 BOLA-DRB2 TNFRSF17 TNFRSF17 TGFB1 TGFB1 CXCL12 CXCL12 LOC104968484 LOC104968484 CD28 CD28 IL15RA IL15RA CD80 CD80 CD86 CD86 LOC786717 LOC786717 DSB DSB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFSF13Tumor necrosis factor (Ligand) superfamily, member 13; Belongs to the tumor necrosis factor family. (250 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
CCL28C-C motif chemokine. (129 aa)
BOLA-DYAMajor histocompatibility complex, class II, DY alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DQBIg-like domain-containing protein. (264 aa)
CCL25C-C motif chemokine ligand 25. (149 aa)
BOLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
BOLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DMBMajor histocompatibility complex, class II, DM beta-chain, expressed. (262 aa)
BOLA-DRB3Ig-like domain-containing protein. (266 aa)
BOLA-DQA5Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ICOSLGIg-like domain-containing protein. (338 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
LOC100848815BOLA-DQA1 protein; Belongs to the MHC class II family. (255 aa)
TNFRSF13BTNF receptor superfamily member 13B. (293 aa)
LTBRLymphotoxin beta receptor. (428 aa)
BOLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (297 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
LOC112445051CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
AICDASingle-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. (199 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (873 aa)
CCR10Chemokine (C-C motif) receptor 10; Belongs to the G-protein coupled receptor 1 family. (365 aa)
BLA-DQBBoLa class II histocompatibility antigen, DQB*0101 beta chain. (261 aa)
PIGRPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. (757 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
ICOSInducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] (209 aa)
BOLA-DQA2Ig-like domain-containing protein; Belongs to the MHC class II family. (301 aa)
TNFRSF13CTNF receptor superfamily member 13C. (185 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
E1BCU0_BOVINIg-like domain-containing protein. (151 aa)
LOC100300510Ig-like domain-containing protein. (226 aa)
BOLA-DYBPutative MHC class II antigen. (259 aa)
TNFSF13BTumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (280 aa)
BOLA-DOBMHC class II DO-beta chain. (271 aa)
LOC100300716Ig-like domain-containing protein. (167 aa)
LOC100296565Ig-like domain-containing protein. (202 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (367 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (252 aa)
ENSBTAP00000059753Uncharacterized protein. (442 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
BOLA-DRB2Ig-like domain-containing protein. (255 aa)
TNFRSF17TNF receptor superfamily member 17. (178 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
LOC104968484Ig-like domain-containing protein. (223 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (265 aa)
IL15RASushi domain-containing protein. (323 aa)
CD80CD80 molecule. (296 aa)
CD86CD86 molecule. (321 aa)
LOC786717Ig-like domain-containing protein. (168 aa)
DSBIg-like domain-containing protein. (270 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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