STRINGSTRING
LTA LTA PRF1 PRF1 IL1B IL1B BOLA-DYA BOLA-DYA BOLA-DQB BOLA-DQB BOLA-DOA BOLA-DOA GAD1 GAD1 GAD2 GAD2 GZMB GZMB IL1A IL1A BOLA-DRA BOLA-DRA FAS FAS BOLA BOLA BOLA-DMB BOLA-DMB IFNG IFNG HSPD1 HSPD1 LOC786126 LOC786126 LOC508858 LOC508858 PTPRN PTPRN BOLA-DRB3 BOLA-DRB3 BOLA-DQA5 BOLA-DQA5 LOC100848815 LOC100848815 BOLA-DMA BOLA-DMA BOLA-NC1 BOLA-NC1 CPE CPE BLA-DQB BLA-DQB IL2 IL2 BOLA-DQA2 BOLA-DQA2 TNF TNF BOLA-2 BOLA-2 FASLG FASLG E1BCU0_BOVIN E1BCU0_BOVIN LOC512672 LOC512672 LOC100300510 LOC100300510 BOLA-DYB BOLA-DYB BOLA-DOB BOLA-DOB LOC100296565 LOC100296565 BoLA BoLA IL12B IL12B PTPRN2 PTPRN2 BOLA-DRB2 BOLA-DRB2 LOC529488 LOC529488 INS INS CD28 CD28 JSP.1 JSP.1 CD80 CD80 CD86 CD86 IL12A IL12A LOC786717 LOC786717 LOC509006 LOC509006 GZMB-2 GZMB-2 LOC505326 LOC505326 DSB DSB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (204 aa)
PRF1Perforin 1. (559 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
BOLA-DYAMajor histocompatibility complex, class II, DY alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DQBIg-like domain-containing protein. (264 aa)
BOLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (268 aa)
BOLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (323 aa)
BOLAIg-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
BOLA-DMBMajor histocompatibility complex, class II, DM beta-chain, expressed. (262 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
LOC786126Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC508858Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
PTPRNReceptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary horm [...] (979 aa)
BOLA-DRB3Ig-like domain-containing protein. (266 aa)
BOLA-DQA5Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC100848815BOLA-DQA1 protein; Belongs to the MHC class II family. (255 aa)
BOLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (297 aa)
BOLA-NC1Ig-like domain-containing protein; Belongs to the MHC class I family. (367 aa)
CPECarboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. (475 aa)
BLA-DQBBoLa class II histocompatibility antigen, DQB*0101 beta chain. (261 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
BOLA-DQA2Ig-like domain-containing protein; Belongs to the MHC class II family. (301 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (333 aa)
BOLA-2BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system. (437 aa)
FASLGLOC407111 protein; Belongs to the tumor necrosis factor family. (277 aa)
E1BCU0_BOVINIg-like domain-containing protein. (151 aa)
LOC512672Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
LOC100300510Ig-like domain-containing protein. (226 aa)
BOLA-DYBPutative MHC class II antigen. (259 aa)
BOLA-DOBMHC class II DO-beta chain. (271 aa)
LOC100296565Ig-like domain-containing protein. (202 aa)
BoLAIg-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (327 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (895 aa)
BOLA-DRB2Ig-like domain-containing protein. (255 aa)
LOC529488Uncharacterized protein. (628 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (265 aa)
JSP.1Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
CD80CD80 molecule. (296 aa)
CD86CD86 molecule. (321 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
LOC786717Ig-like domain-containing protein. (168 aa)
LOC509006Ig-like domain-containing protein; Belongs to the MHC class I family. (374 aa)
GZMB-2Duodenase-1; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. (251 aa)
LOC505326Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
DSBIg-like domain-containing protein. (270 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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