STRINGSTRING
IL3 IL3 BOLA-DYA BOLA-DYA BOLA-DQB BOLA-DQB CCL11 CCL11 BOLA-DOA BOLA-DOA BOLA-DRA BOLA-DRA BOLA-DMB BOLA-DMB FCER1A FCER1A BOLA-DRB3 BOLA-DRB3 BOLA-DQA5 BOLA-DQA5 LOC100848815 LOC100848815 BOLA-DMA BOLA-DMA IL13 IL13 IL4 IL4 LOC112445051 LOC112445051 IL9 IL9 BLA-DQB BLA-DQB MS4A2 MS4A2 CD40 CD40 FCER1G FCER1G BOLA-DQA2 BOLA-DQA2 TNF TNF IL5 IL5 E1BCU0_BOVIN E1BCU0_BOVIN LOC100300510 LOC100300510 BOLA-DYB BOLA-DYB BOLA-DOB BOLA-DOB LOC100300716 LOC100300716 LOC100296565 LOC100296565 IL10 IL10 ENSBTAP00000059753 ENSBTAP00000059753 BOLA-DRB2 BOLA-DRB2 LOC104968484 LOC104968484 LOC786717 LOC786717 DSB DSB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (144 aa)
BOLA-DYAMajor histocompatibility complex, class II, DY alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DQBIg-like domain-containing protein. (264 aa)
CCL11Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. (97 aa)
BOLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
BOLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DMBMajor histocompatibility complex, class II, DM beta-chain, expressed. (262 aa)
FCER1AFc fragment of IgE receptor Ia. (260 aa)
BOLA-DRB3Ig-like domain-containing protein. (266 aa)
BOLA-DQA5Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC100848815BOLA-DQA1 protein; Belongs to the MHC class II family. (255 aa)
BOLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (297 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (132 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
LOC112445051CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
IL9Interleukin 9. (141 aa)
BLA-DQBBoLa class II histocompatibility antigen, DQB*0101 beta chain. (261 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (85 aa)
BOLA-DQA2Ig-like domain-containing protein; Belongs to the MHC class II family. (301 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (333 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
E1BCU0_BOVINIg-like domain-containing protein. (151 aa)
LOC100300510Ig-like domain-containing protein. (226 aa)
BOLA-DYBPutative MHC class II antigen. (259 aa)
BOLA-DOBMHC class II DO-beta chain. (271 aa)
LOC100300716Ig-like domain-containing protein. (167 aa)
LOC100296565Ig-like domain-containing protein. (202 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (252 aa)
ENSBTAP00000059753Uncharacterized protein. (442 aa)
BOLA-DRB2Ig-like domain-containing protein. (255 aa)
LOC104968484Ig-like domain-containing protein. (223 aa)
LOC786717Ig-like domain-containing protein. (168 aa)
DSBIg-like domain-containing protein. (270 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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