STRINGSTRING
PRF1 PRF1 BOLA-DYA BOLA-DYA BOLA-DQB BOLA-DQB TSHB TSHB BOLA-DOA BOLA-DOA GZMB GZMB BOLA-DRA BOLA-DRA FAS FAS BOLA BOLA BOLA-DMB BOLA-DMB LOC786126 LOC786126 LOC508858 LOC508858 CTLA4 CTLA4 BOLA-DRB3 BOLA-DRB3 BOLA-DQA5 BOLA-DQA5 LOC100848815 LOC100848815 BOLA-DMA BOLA-DMA IL4 IL4 BOLA-NC1 BOLA-NC1 LOC112445051 LOC112445051 BLA-DQB BLA-DQB CD40 CD40 IL2 IL2 LOC523244 LOC523244 BOLA-DQA2 BOLA-DQA2 BOLA-2 BOLA-2 IL5 IL5 FASLG FASLG E1BCU0_BOVIN E1BCU0_BOVIN LOC512672 LOC512672 LOC100300510 LOC100300510 IFNAC IFNAC LOC100335490 LOC100335490 TSHR TSHR BOLA-DYB BOLA-DYB LOC618947 LOC618947 LOC787343 LOC787343 BOLA-DOB BOLA-DOB LOC100300716 LOC100300716 LOC100296565 LOC100296565 IL10 IL10 ENSBTAP00000059753 ENSBTAP00000059753 BoLA BoLA BOLA-DRB2 BOLA-DRB2 TG TG CGA CGA TPO TPO LOC104968484 LOC104968484 CD28 CD28 JSP.1 JSP.1 CD80 CD80 CD86 CD86 LOC786717 LOC786717 LOC509006 LOC509006 IFNAD IFNAD GZMB-2 GZMB-2 LOC505326 LOC505326 DSB DSB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRF1Perforin 1. (559 aa)
BOLA-DYAMajor histocompatibility complex, class II, DY alpha; Belongs to the MHC class II family. (253 aa)
BOLA-DQBIg-like domain-containing protein. (264 aa)
TSHBThyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
BOLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
BOLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (323 aa)
BOLAIg-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
BOLA-DMBMajor histocompatibility complex, class II, DM beta-chain, expressed. (262 aa)
LOC786126Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC508858Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (221 aa)
BOLA-DRB3Ig-like domain-containing protein. (266 aa)
BOLA-DQA5Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC100848815BOLA-DQA1 protein; Belongs to the MHC class II family. (255 aa)
BOLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (297 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
BOLA-NC1Ig-like domain-containing protein; Belongs to the MHC class I family. (367 aa)
LOC112445051CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
BLA-DQBBoLa class II histocompatibility antigen, DQB*0101 beta chain. (261 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
LOC523244Uncharacterized protein. (189 aa)
BOLA-DQA2Ig-like domain-containing protein; Belongs to the MHC class II family. (301 aa)
BOLA-2BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system. (437 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
FASLGLOC407111 protein; Belongs to the tumor necrosis factor family. (277 aa)
E1BCU0_BOVINIg-like domain-containing protein. (151 aa)
LOC512672Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
LOC100300510Ig-like domain-containing protein. (226 aa)
IFNACInterferon alpha-G; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (189 aa)
LOC100335490Uncharacterized protein. (189 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (763 aa)
BOLA-DYBPutative MHC class II antigen. (259 aa)
LOC618947Uncharacterized protein. (189 aa)
LOC787343IFN-Chi1. (186 aa)
BOLA-DOBMHC class II DO-beta chain. (271 aa)
LOC100300716Ig-like domain-containing protein. (167 aa)
LOC100296565Ig-like domain-containing protein. (202 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (252 aa)
ENSBTAP00000059753Uncharacterized protein. (442 aa)
BoLAIg-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
BOLA-DRB2Ig-like domain-containing protein. (255 aa)
TGThyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). Belongs to the type-B carboxylesterase/lipase family. (2770 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
TPOThyroid peroxidase. (903 aa)
LOC104968484Ig-like domain-containing protein. (223 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (265 aa)
JSP.1Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
CD80CD80 molecule. (296 aa)
CD86CD86 molecule. (321 aa)
LOC786717Ig-like domain-containing protein. (168 aa)
LOC509006Ig-like domain-containing protein; Belongs to the MHC class I family. (374 aa)
IFNADInterferon alpha-H; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (189 aa)
GZMB-2Duodenase-1; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. (251 aa)
LOC505326Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
DSBIg-like domain-containing protein. (270 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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