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| | GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B. (1497 aa) |
| | H2AFY2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | BOLA-DYA | Major histocompatibility complex, class II, DY alpha; Belongs to the MHC class II family. (253 aa) |
| | BOLA-DQB | Ig-like domain-containing protein. (264 aa) |
| | C8A | Complement C8 alpha chain. (589 aa) |
| | H2AFZ | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (128 aa) |
| | BOLA-DOA | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | C4A | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). (1741 aa) |
| | C1QA | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (244 aa) |
| | HIST1H2AC | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | SNRPD1 | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa) |
| | FCGR1A | Uncharacterized protein. (349 aa) |
| | SSB | Lupus La protein homolog; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. (404 aa) |
| | LOC614881 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC619094 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | BOLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa) |
| | HIST1H2AG | Histone H2A type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa) |
| | C1QC | Complement C1q C chain. (243 aa) |
| | C1QB | Complement C1q subcomponent subunit B; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity). (247 aa) |
| | C5 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. (1677 aa) |
| | BOLA-DMB | Major histocompatibility complex, class II, DM beta-chain, expressed. (262 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | LOC404073 | Histone H2B subacrosomal variant; May act as an acrosome-nuclear docking protein in sperm. (122 aa) |
| | RO60 | Ro60, Y RNA binding protein. (856 aa) |
| | TRIM21 | E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degrad [...] (469 aa) |
| | BOLA-DRB3 | Ig-like domain-containing protein. (266 aa) |
| | BOLA-DQA5 | Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa) |
| | LOC100848815 | BOLA-DQA1 protein; Belongs to the MHC class II family. (255 aa) |
| | BOLA-DMA | Ig-like domain-containing protein; Belongs to the MHC class II family. (297 aa) |
| | LOC100301024 | Histone domain-containing protein; Belongs to the histone H2B family. (129 aa) |
| | H2AFY | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa) |
| | C9 | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. (548 aa) |
| | H2AFV | Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (128 aa) |
| | C3 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (1661 aa) |
| | LOC112445051 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | LOC525863 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | BLA-DQB | BoLa class II histocompatibility antigen, DQB*0101 beta chain. (261 aa) |
| | HIST1H2BD | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa) |
| | LOC104975684 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC101904455 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | C8B | Complement C8 beta chain. (590 aa) |
| | H3F3A | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | BOLA-DQA2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (301 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (333 aa) |
| | F1N6G1_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (146 aa) |
| | H2AFJ | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa) |
| | H2AC18 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | HIST1H2BB | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | C2 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. (787 aa) |
| | LOC107131209 | Uncharacterized protein. (1735 aa) |
| | H2AC21 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H3F3C | Histone H3.3C-like; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | E1BM22_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC526064 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC524236 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | E1BCU0_BOVIN | Ig-like domain-containing protein. (151 aa) |
| | HIST3H2A | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2B | Histone H2B type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | H4 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC525433 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | HIST1H2AC-2 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H3F3C-2 | Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | E1BAA6_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | H2B-3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | E1BHL3_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | HIST2H3D | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC615183 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | LOC100300510 | Ig-like domain-containing protein. (226 aa) |
| | HIST2H2AC | Histone H2A type 2-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | LOC505658 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HIST1H2BN | Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | ELANE | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (286 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | G3MXG1_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | HIST1H2AA | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | LOC107132069 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | G3MXW2_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (174 aa) |
| | BOLA-DYB | Putative MHC class II antigen. (259 aa) |
| | LOC100297725 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC523458 | Histone domain-containing protein; Belongs to the histone H2B family. (163 aa) |
| | G3MZR4_BOVIN | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G3N0F3_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | BOLA-DOB | MHC class II DO-beta chain. (271 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC107133263 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G3N1G0_BOVIN | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC100300716 | Ig-like domain-containing protein. (167 aa) |
| | LOC526226 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC613345 | Histone domain-containing protein. (136 aa) |
| | LOC613363 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC528006 | Histone H2A; Belongs to the histone H2A family. (109 aa) |
| | LOC100296565 | Ig-like domain-containing protein. (202 aa) |
| | ENSBTAP00000057003 | Histone H2A; Belongs to the histone H2A family. (84 aa) |
| | C6 | Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. (935 aa) |
| | LOC107131556 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | C7 | Complement component C7; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity). (843 aa) |
| | HIST1H3C | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (252 aa) |
| | ENSBTAP00000059753 | Uncharacterized protein. (442 aa) |
| | LOC112445458-2 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC617633 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | LOC788077 | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | BOLA-DRB2 | Ig-like domain-containing protein. (255 aa) |
| | SNRPB | Small nuclear ribonucleoprotein-associated protein. (242 aa) |
| | ENSBTAP00000066097 | Histone H2B; Belongs to the histone H2B family. (67 aa) |
| | C1S | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). (697 aa) |
| | ENSBTAP00000068150 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104968484 | Ig-like domain-containing protein. (223 aa) |
| | FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III; Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody-dependent cellular toxicity (By similarity). (257 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (265 aa) |
| | C1R | Complement C1r; Belongs to the peptidase S1 family. (713 aa) |
| | CD80 | CD80 molecule. (296 aa) |
| | SNRPD3 | Small nuclear ribonucleoprotein D3 polypeptide. (349 aa) |
| | ACTN4 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (1032 aa) |
| | CD86 | CD86 molecule. (321 aa) |
| | LOC523631 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | LOC786717 | Ig-like domain-containing protein. (168 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ACTN1 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa) |
| | LOC781224 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | DSB | Ig-like domain-containing protein. (270 aa) |
