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| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | ADZ68448.1 | Hypothetical protein. (173 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | ADZ68450.1 | Hypothetical conserved protein. (95 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (248 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (107 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (226 aa) |
| | aroE-2 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa) |
| | ADZ68534.1 | Chorismate mutase protein. (114 aa) |
| | argH | Argininosuccinate lyase 1. (457 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (424 aa) |
| | ADZ68582.1 | Aminotransferase, classes I and II superfamily. (412 aa) |
| | ADZ68589.1 | Bacterial NAD-glutamate dehydrogenase superfamily. (1601 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase 2; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (316 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (304 aa) |
| | ADZ68651.1 | Prephenate dehydrogenase protein. (305 aa) |
| | hisC | Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (371 aa) |
| | ADZ68653.1 | Chorismate mutase. (294 aa) |
| | argG | Argininosuccinate synthase 2; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | ADZ68681.1 | Glutamine synthetase activity regulation protein; Belongs to the P(II) protein family. (112 aa) |
| | ADZ68682.1 | Ammonium transporter. (469 aa) |
| | aroB | Shikimate kinase, 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) |
| | aroK | Shikimate kinase, 3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (209 aa) |
| | ADZ68785.1 | Conserved domain protein. (333 aa) |
| | ADZ68786.1 | Nitrogen regulatory protein P-II. (103 aa) |
| | asd | Aspartate-B-semialdehyde dehydrogenase protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuB | 3-isopropylmalate dehydrogenase 2; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | ADZ68908.1 | Aspartokinase; Belongs to the aspartokinase family. (416 aa) |
| | ADZ68977.1 | Hypothetical protein; Belongs to the TPP enzyme family. (550 aa) |
| | ADZ69197.1 | Dehydratase family; Belongs to the IlvD/Edd family. (599 aa) |
| | ADZ69277.1 | Probable glutamate synthase small chain protein. (476 aa) |
| | gltB | Glutamate synthase [NADPH] large chain (Glutamate synthase alpha subunit) eukaryotic ferredoxin-dependent glutamate synthase 1 (GLU1)-like protein. (1582 aa) |
| | ADZ69283.1 | Beta-eliminating lyase superfamily; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (353 aa) |
| | ADZ69514.1 | Glutamate dehydrogenase (NAD(P)(+)); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (372 aa) |
| | ADZ69549.1 | Acetolactate synthase II; Belongs to the TPP enzyme family. (611 aa) |
| | proC | Pyrroline-5-carboxylate reductase protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | ilvE-2 | Putative branched-chain amino acid transferase (IlvE-like); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (299 aa) |
| | aatA | Aminotransferase, classes I and II superfamily. (399 aa) |
| | katG | Catalase-peroxidase 1; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (723 aa) |
| | ADZ69747.1 | Hydantoinase/oxoprolinase domain family protein. (1194 aa) |
| | ADZ69813.1 | Putative phosphoserine phosphatase (SerB-like). (297 aa) |
| | leuA | Putative HMGL-like protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (518 aa) |
| | ilvC | Acetohydroxy acid isomeroreductase-like protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvH | Acetolactate synthase, small subunit. (190 aa) |
| | ADZ69833.1 | Putative acetolactate synthase large subunit-like protein. (591 aa) |
| | ADZ69915.1 | Threonine dehydratase catabolic, TdcB. (327 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase domain protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (153 aa) |
| | dapA-2 | Dihydrodipicolinate synthase subfamily; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | ADZ70334.1 | Threonine dehydratase. (413 aa) |
| | amiF | Formamidase; Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. (339 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | glnA3 | Glutamine synthetase 1. (469 aa) |
| | ADZ70485.1 | Regulatory protein, P-II 2, for nitrogen assimilation by glutamine synthetase, regulates GlnL (NRII) and GlnE (ATase). (112 aa) |
| | trpC | Indole-3-glycerol phosphate synthase protein; Belongs to the TrpC family. (276 aa) |
| | trpD | Anthranilate phosphoribosyltransferase 2; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | ADZ70697.1 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (451 aa) |
| | ADZ70948.1 | Hypothetical protein. (92 aa) |
| | ADZ70950.1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (596 aa) |
| | ADZ70951.1 | Cupin 2 conserved barrel domain protein. (122 aa) |
| | trpE | Anthranilate synthase / glutamine amidotransferase protein. (728 aa) |
| | ADZ71082.1 | Homoserine dehydrogenase. (433 aa) |
| | ilvD | Dihydroxy-acid dehydratase 1; Belongs to the IlvD/Edd family. (614 aa) |
| | leuA1 | Putative isopropylmalate synthase (LeuA-like); Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa) |
| | ADZ71173.1 | 3-deoxy-7-phosphoheptulonate synthase (Phospho-2-dehydro-3-deoxyheptonate aldolase) (DAHP synthetase class II). (460 aa) |
| | ilvE | Branched-chain amino acid aminotransferase 1. (326 aa) |
| | ADZ71303.1 | Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (434 aa) |
| | ADZ71358.1 | Glutamate synthase, large subunit, putative; Belongs to the glutamate synthase family. (539 aa) |
| | ADZ71401.1 | Aminotransferase, class IV superfamily. (285 aa) |
| | ADZ71418.1 | Aminotransferase, classes I and II superfamily. (409 aa) |
| | hisD | Histidinol dehydrogenase 1; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | dapB | Dihydrodipicolinate reductase (DapB); Belongs to the DapB family. (247 aa) |
| | dapA | Strongly dihydropicolinate synthase (DHDPS)-like protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa) |
| | ilvB | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (544 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase 2; Belongs to the IlvD/Edd family. (585 aa) |
| | ADZ71590.1 | L-lactate dehydrogenase (Cytochrome). (384 aa) |
| | aroE | Shikimate 5-dehydrogenase/quinate 5-dehydrogenase family protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (296 aa) |
| | argF | Ornithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (309 aa) |
| | argD | Bifunctional N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | ADZ71740.1 | Oxidoreductase, FAD-binding protein. (470 aa) |
| | thrC | Threonine synthetase protein. (468 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit. (383 aa) |
| | hisG | ATP phosphoribosyltransferase family; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (323 aa) |
| | ADZ71912.1 | Putative glutamate--cysteine ligase protein; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (457 aa) |
| | ilvG | Putative acetohydroxyacid synthase large subunit-like protein; Belongs to the TPP enzyme family. (560 aa) |
| | ADZ71935.1 | Threonine dehydratase, putative. (324 aa) |
| | ADZ71945.1 | Glutamine synthetase, putative. (461 aa) |
| | ADZ71947.1 | Glutamine synthetase, catalytic domain, putative. (464 aa) |
| | ipuC | Glutamine synthetase, catalytic domain, putative. (455 aa) |
| | ADZ72008.1 | L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (462 aa) |
| | ADZ72012.1 | Pyridoxal-dependent amino acid decarboxylase protein. (471 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (282 aa) |
| | dapE | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase-like deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (393 aa) |
| | ADZ72122.1 | Proline dehydrogenase family; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1042 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (170 aa) |
| | ADZ72253.1 | 3-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (438 aa) |
| | ADZ72261.1 | Betaine-aldehyde dehydrogenase protein; Belongs to the aldehyde dehydrogenase family. (475 aa) |
| | proB | Glutamate 5-kinase 1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (378 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa) |
| | glnD | UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (942 aa) |
| | ADZ72711.1 | Prephenate dehydratase domain protein. (296 aa) |
| | dapB-2 | Dihydrodipicolinate reductase protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (256 aa) |
