STRINGSTRING
ADZ68493.1 ADZ68493.1 sdhB sdhB sdhA sdhA ADZ68625.1 ADZ68625.1 ADZ68626.1 ADZ68626.1 ADZ68692.1 ADZ68692.1 fdxA fdxA ADZ68837.1 ADZ68837.1 ADZ68975.1 ADZ68975.1 purU purU ADZ69148.1 ADZ69148.1 gabD1 gabD1 ADZ69258.1 ADZ69258.1 fumC fumC ADZ69463.1 ADZ69463.1 ADZ69465.1 ADZ69465.1 ADZ69466.1 ADZ69466.1 ADZ69467.1 ADZ69467.1 pdhA pdhA ADZ69512.1 ADZ69512.1 ADZ69513.1 ADZ69513.1 pdhA-2 pdhA-2 ADZ69522.1 ADZ69522.1 fdnG fdnG ADZ69708.1 ADZ69708.1 fdxH fdxH ADZ69710.1 ADZ69710.1 ADZ69711.1 ADZ69711.1 selA selA ADZ69713.1 ADZ69713.1 ADZ69794.1 ADZ69794.1 ADZ69991.1 ADZ69991.1 ADZ69994.1 ADZ69994.1 ADZ70022.1 ADZ70022.1 ppdK ppdK lipB lipB ADZ70298.1 ADZ70298.1 gltA gltA ADZ70552.1 ADZ70552.1 fdsB fdsB fdsA fdsA fdsD fdsD lipA lipA ADZ70743.1 ADZ70743.1 pdhB pdhB ADZ70745.1 ADZ70745.1 pdhA-3 pdhA-3 ADZ70887.1 ADZ70887.1 ADZ70888.1 ADZ70888.1 ADZ70889.1 ADZ70889.1 ADZ70890.1 ADZ70890.1 ADZ70895.1 ADZ70895.1 ADZ70949.1 ADZ70949.1 ADZ70960.1 ADZ70960.1 ADZ70961.1 ADZ70961.1 ADZ71222.1 ADZ71222.1 fumB fumB glcB glcB ADZ71709.1 ADZ71709.1 ADZ71773.1 ADZ71773.1 ADZ72247.1 ADZ72247.1 ADZ72506.1 ADZ72506.1 pckA pckA ADZ72646.1 ADZ72646.1 sucB sucB sucA sucA sucD sucD sucC sucC mdh mdh
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ADZ68493.1Phosphate acetyl/butyryl transferase subfamily, putative. (760 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (608 aa)
ADZ68625.1Succinate dehydrogenase, hydrophobic membrane anchor protein, putative. (127 aa)
ADZ68626.1Succinate dehydrogenase, cytochrome b556 subunit. (132 aa)
ADZ68692.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
fdxAFerredoxin II; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (112 aa)
ADZ68837.1Probable pyruvate carboxylase protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
ADZ68975.1Probable 3-isopropylmalate dehydrogenase oxidoreductase protein. (351 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
ADZ69148.14-aminobutyrate aminotransferase ((S)-3-amino-2-methylpropionate transaminase); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
gabD1Succinate-semialdehyde dehydrogenase [NADP+] (SSDH); Belongs to the aldehyde dehydrogenase family. (483 aa)
ADZ69258.1Putative Indolepyruvate ferredoxin oxidoreductase; iorA-like protein. (1151 aa)
fumCPutative Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
ADZ69463.1Pyruvate dehydrogenase (Acetyl-transferring). (341 aa)
ADZ69465.1Acetoin dehydrogenase E1 component beta-subunit. (324 aa)
ADZ69466.1Succinate-semialdehyde dehydrogenase (NAD(P)+); Belongs to the aldehyde dehydrogenase family. (483 aa)
ADZ69467.12-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (446 aa)
pdhAPyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa)
ADZ69512.1Pyruvate dehydrogenase (Acetyl-transferring) E1 component, beta subunit. (326 aa)
ADZ69513.1Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes. (365 aa)
pdhA-2Dehydrogenase, E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (665 aa)
ADZ69522.1Probable pyruvate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase. (411 aa)
fdnGFormate dehydrogenase, major subunit. (165 aa)
ADZ69708.1Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (813 aa)
fdxHFormate dehydrogenase, beta subunit. (302 aa)
ADZ69710.1Formate dehydrogenase, gamma subunit. (222 aa)
ADZ69711.1Formate dehydrogenase accessory protein FdhE; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (308 aa)
selASelenocysteine synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (465 aa)
ADZ69713.1Sel1-like repeat protein. (258 aa)
ADZ69794.1Putative lactate dehydrogenase D-like protein. (473 aa)
ADZ69991.1Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
ADZ69994.1Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (762 aa)
ADZ70022.12-oxoacid:ferredoxin/flavodoxin oxidoreductase, gamma subunit domain protein. (1160 aa)
ppdKPyruvate phosphate dikinase (Pyruvate, orthophosphate dikinase); Belongs to the PEP-utilizing enzyme family. (887 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (237 aa)
ADZ70298.1Alpha/beta hydrolase fold-3 domain protein. (283 aa)
gltACitrate synthase, chromosomal; Belongs to the citrate synthase family. (430 aa)
ADZ70552.1ATP synthase subunit E. (157 aa)
fdsBNADH dehydrogenase (Quinone). (525 aa)
fdsAFormate dehydrogenase, alpha subunit protein. (959 aa)
fdsDFormate dehydrogenase protein, delta subunit. (77 aa)
lipALipoyl synthase 1; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
ADZ70743.1Dihydrolipoyl dehydrogenase. (480 aa)
pdhBDihydrolipoamide acetyltransferase protein. (308 aa)
ADZ70745.1Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (458 aa)
pdhA-3Pyruvate dehydrogenase (Acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (350 aa)
ADZ70887.1Lipoate-protein ligase A-like protein. (252 aa)
ADZ70888.1Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2). (78 aa)
ADZ70889.1TPP-dependent acetoin dehydrogenase complex, E1 component, beta subunit. (339 aa)
ADZ70890.1Pyruvate dehydrogenase (Acetyl-transferring). (328 aa)
ADZ70895.1Citrate synthase. (265 aa)
ADZ70949.1Fumarate reductase/succinate dehydrogenase flavoprotein-like protein. (589 aa)
ADZ70960.1Citrate utilization protein B. (373 aa)
ADZ70961.1Precorrin 3B synthase CobZ. (465 aa)
ADZ71222.1Succinate-semialdehyde dehydrogenase subfamily; Belongs to the aldehyde dehydrogenase family. (485 aa)
fumBFumarate hydratase I, N-terminal region or alpha subunit domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (545 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa)
ADZ71709.1Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
ADZ71773.1Phosphate acetyl/butyryl transferase subfamily, putative. (765 aa)
ADZ72247.1Fumarate reductase/succinate dehydrogenase flavoprotein-like protein. (467 aa)
ADZ72506.1Pyruvate dehydrogenase (Acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (784 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
ADZ72646.1Dihydrolipoamide dehydrogenase protein. (467 aa)
sucB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (508 aa)
sucAOxoglutarate dehydrogenase (Succinyl-transferring), E1 component. (995 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (302 aa)
sucCSuccinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
mdhMalate dehydrogenase 1; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
Your Current Organism:
Polymorphum gilvum
NCBI taxonomy Id: 991905
Other names: P. gilvum SL003B-26A1, Polymorphum gilvum SL003B-26A1, Polymorphum gilvum str. SL003B-26A1, Polymorphum gilvum strain SL003B-26A1, proteobacterium SL003B-26A1
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