STRINGSTRING
hisB hisB trpA trpA trpB trpB nth nth fabA fabA leuC leuC leuD leuD phhB phhB ADZ68692.1 ADZ68692.1 aroB aroB cah cah ADZ68811.1 ADZ68811.1 ADZ68816.1 ADZ68816.1 ADZ68964.1 ADZ68964.1 ADZ69197.1 ADZ69197.1 nthB nthB ADZ69249.1 ADZ69249.1 fumC fumC psuG psuG ADZ70056.1 ADZ70056.1 ADZ70284.1 ADZ70284.1 ADZ70290.1 ADZ70290.1 dapA-2 dapA-2 hemB hemB ADZ70336.1 ADZ70336.1 ADZ70370.1 ADZ70370.1 ADZ70401.1 ADZ70401.1 aroQ aroQ fabZ fabZ ADZ70580.1 ADZ70580.1 eno eno ADZ70766.1 ADZ70766.1 uxuA uxuA ADZ70929.1 ADZ70929.1 ADZ70938.1 ADZ70938.1 gmd gmd ilvD ilvD fumB fumB fad fad dapA dapA ADZ71583.1 ADZ71583.1 ilvD-2 ilvD-2 uxuA-2 uxuA-2 ADZ71646.1 ADZ71646.1 fadB fadB ADZ71714.1 ADZ71714.1 aroC aroC thrC thrC ADZ71862.1 ADZ71862.1 ADZ71866.1 ADZ71866.1 ADZ71970.1 ADZ71970.1 ADZ71971.1 ADZ71971.1 ADZ71973.1 ADZ71973.1 mgsA mgsA ADZ72221.1 ADZ72221.1 leuD-2 leuD-2 ADZ72253.1 ADZ72253.1 ADZ72347.1 ADZ72347.1 ADZ72499.1 ADZ72499.1 ADZ72522.1 ADZ72522.1 ADZ72711.1 ADZ72711.1 mutM mutM ADZ72749.1 ADZ72749.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisBImidazoleglycerol-phosphate dehydratase. (197 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (284 aa)
fabABeta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (168 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
phhBPutative Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (4-alpha-hydroxy-tetrahydropterin dehydratase 2). (98 aa)
ADZ68692.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
aroBShikimate kinase, 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
cahCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (220 aa)
ADZ68811.1Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (233 aa)
ADZ68816.1Enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
ADZ68964.1Hypothetical cytosolic protein. (272 aa)
ADZ69197.1Dehydratase family; Belongs to the IlvD/Edd family. (599 aa)
nthBNitrile hydratase, beta subunit; NHase catalyzes the hydration of various nitrile compounds to the corresponding amides; Belongs to the nitrile hydratase subunit beta family. (219 aa)
ADZ69249.1Nitrile hydratase, alpha subunit. (215 aa)
fumCPutative Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
psuGPseudouridine-5'-phosphate glycosidase 1; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (313 aa)
ADZ70056.1Enoyl-CoA hydratase/isomerase family protein. (268 aa)
ADZ70284.1Enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa)
ADZ70290.1Dihydrodipicolinate synthase family protein; Belongs to the DapA family. (318 aa)
dapA-2Dihydrodipicolinate synthase subfamily; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (345 aa)
ADZ70336.1Enoyl-CoA hydratase/isomerase family protein. (349 aa)
ADZ70370.1Enoyl-CoA hydratase/isomerase family protein. (274 aa)
ADZ70401.12-oxo-hepta-3-ene-1,7-dioic acid hydratase, putative. (271 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa)
ADZ70580.1Enoyl-CoA hydratase / short chain enoyl-CoA hydratase. (266 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
ADZ70766.1Dihydrodipicolinate synthetase family; Belongs to the DapA family. (308 aa)
uxuAMannonate dehydratase 1; Catalyzes the dehydration of D-mannonate. (408 aa)
ADZ70929.1Putative 4-hydroxyphenylpyruvate dioxygenase protein. (638 aa)
ADZ70938.1Putative bifunctional anaerobic fatty acid oxidation complex protein (FadJ/fadB-like): enoyl-CoA hydratase/epimerase/isomerase (N-terminal); 3-hydroxyacyl-CoA dehydrogenase (C-terminal). (460 aa)
gmdProbable gdp-mannose 4,6-dehydratase protein; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (326 aa)
ilvDDihydroxy-acid dehydratase 1; Belongs to the IlvD/Edd family. (614 aa)
fumBFumarate hydratase I, N-terminal region or alpha subunit domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (545 aa)
fadEnoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (263 aa)
dapAStrongly dihydropicolinate synthase (DHDPS)-like protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa)
ADZ71583.1Putative trifunctional protein; Belongs to the enoyl-CoA hydratase/isomerase family. (691 aa)
ilvD-2Dihydroxy-acid dehydratase 2; Belongs to the IlvD/Edd family. (585 aa)
uxuA-2Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (386 aa)
ADZ71646.1Secondary thiamine-phosphate synthase enzyme. (155 aa)
fadB3-hydroxyacyl-CoA dehydrogenase, C-terminal domain family; Belongs to the enoyl-CoA hydratase/isomerase family. (738 aa)
ADZ71714.1Enoyl-CoA hydratase/isomerase family protein. (248 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
thrCThreonine synthetase protein. (468 aa)
ADZ71862.1Probable maoC-like dehydratase. (133 aa)
ADZ71866.1Dehydrogenase with MaoC-like domain. (150 aa)
ADZ71970.1MaoC-like dehydratase, putative. (124 aa)
ADZ71971.1Chain A, (R)-Hydratase; Similar to A. caviae protein; involved in Pha Biosynthesis. (131 aa)
ADZ71973.1Enoyl-CoA hydratase/isomerase family protein. (257 aa)
mgsAPutative methylglyoxal synthase (Methylglyoxal synthase); Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (142 aa)
ADZ72221.1Enoyl-CoA hydratase; Similar to mitochondrial precursor (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1); Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (170 aa)
ADZ72253.13-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (438 aa)
ADZ72347.1Hypothetical protein. (133 aa)
ADZ72499.1Dihydrodipicolinate synthetase; Belongs to the DapA family. (331 aa)
ADZ72522.1Dihydrodipicolinate synthetase; Belongs to the DapA family. (331 aa)
ADZ72711.1Prephenate dehydratase domain protein. (296 aa)
mutMFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (280 aa)
ADZ72749.1Enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
Your Current Organism:
Polymorphum gilvum
NCBI taxonomy Id: 991905
Other names: P. gilvum SL003B-26A1, Polymorphum gilvum SL003B-26A1, Polymorphum gilvum str. SL003B-26A1, Polymorphum gilvum strain SL003B-26A1, proteobacterium SL003B-26A1
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