STRINGSTRING
fdsB fdsB nth nth leuC leuC ADZ68598.1 ADZ68598.1 rlmN rlmN sdhB sdhB ADZ68692.1 ADZ68692.1 ispG ispG pqqE pqqE fdxA fdxA phnJ phnJ ADZ68987.1 ADZ68987.1 ADZ68988.1 ADZ68988.1 ADZ69002.1 ADZ69002.1 ADZ69258.1 ADZ69258.1 fdnG fdnG ADZ69708.1 ADZ69708.1 ttcA ttcA ADZ70022.1 ADZ70022.1 ADZ70328.1 ADZ70328.1 nuoB1 nuoB1 nuoF nuoF ADZ70499.1 ADZ70499.1 nuoI1 nuoI1 ADZ70537.1 ADZ70537.1 ADZ70543.1 ADZ70543.1 hemN hemN fdsA fdsA lipA lipA sufB sufB ADZ70810.1 ADZ70810.1 ADZ70960.1 ADZ70960.1 fumB fumB moaA moaA ADZ71248.1 ADZ71248.1 ADZ71630.1 ADZ71630.1 hemN-2 hemN-2 ADZ71727.1 ADZ71727.1 nadA nadA ADZ71770.1 ADZ71770.1 ADZ71771.1 ADZ71771.1 ADZ71778.1 ADZ71778.1 ADZ71788.1 ADZ71788.1 ispH ispH ADZ71896.1 ADZ71896.1 ADZ71904.1 ADZ71904.1 ADZ71954.1 ADZ71954.1 ADZ72008.1 ADZ72008.1 ADZ72253.1 ADZ72253.1 queG queG miaB miaB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fdsBNADH dehydrogenase (Quinone). (525 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (284 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
ADZ68598.1Putative methylase protein (RNA modification enzyme), MiaB family. (422 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (414 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
ADZ68692.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (425 aa)
pqqECoenzyme PQQ biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (361 aa)
fdxAFerredoxin II; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (112 aa)
phnJPhosphonate metabolism protein, C-P (carbon-phosphorus) lyase component; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (313 aa)
ADZ68987.1Peptidase U32. (298 aa)
ADZ68988.1Peptidase U32. (342 aa)
ADZ69002.1Nitrite reductase heme biosynthesis J protein. (406 aa)
ADZ69258.1Putative Indolepyruvate ferredoxin oxidoreductase; iorA-like protein. (1151 aa)
fdnGFormate dehydrogenase, major subunit. (165 aa)
ADZ69708.1Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (813 aa)
ttcAATPase, PP superfamily; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (322 aa)
ADZ70022.12-oxoacid:ferredoxin/flavodoxin oxidoreductase, gamma subunit domain protein. (1160 aa)
ADZ70328.1Uracil DNA glycosylase superfamily. (222 aa)
nuoB1NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (193 aa)
nuoFNadh dehydrogenase i chain f transmembrane protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (433 aa)
ADZ70499.1NADH-quinone oxidoreductase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (687 aa)
nuoI1NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa)
ADZ70537.1Fe-s oxidoreductase protein. (449 aa)
ADZ70543.1Radical SAM domain protein. (640 aa)
hemNCoproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
fdsAFormate dehydrogenase, alpha subunit protein. (959 aa)
lipALipoyl synthase 1; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
sufBABC transporter involved in Fe-S cluster assembly, permease protein. (490 aa)
ADZ70810.1Molybdopterin oxidoreductase domain protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (720 aa)
ADZ70960.1Citrate utilization protein B. (373 aa)
fumBFumarate hydratase I, N-terminal region or alpha subunit domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (545 aa)
moaARadical SAM:Molybdenum cofactor synthesis-like protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (353 aa)
ADZ71248.1Uracil DNA glycosylase superfamily. (228 aa)
ADZ71630.1Cytochrome c oxidase accessory protein CcoG. (485 aa)
hemN-2Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen oxidase); Belongs to the anaerobic coproporphyrinogen-III oxidase family. (454 aa)
ADZ71727.1tRNA (Uracil-5-)-methyltransferase superfamily; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (411 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (365 aa)
ADZ71770.1Uracil-DNA glycosylase, family 4, putative. (300 aa)
ADZ71771.1Electrotransfer ubiquinone oxidoreductase protein; Accepts electrons from ETF and reduces ubiquinone. (557 aa)
ADZ71778.1Nitrogenase cofactor biosynthesis protein NifB. (384 aa)
ADZ71788.1Probable a/g-specific adenine glycosylase protein; Adenine glycosylase active on G-A mispairs. (362 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (341 aa)
ADZ71896.1Glycolate oxidase iron-sulfur subunit. (449 aa)
ADZ71904.1Cysteine-rich domain of 2-hydroxy-acid oxidase GlcF-like protein. (258 aa)
ADZ71954.1Sulfite reductase (NADPH) hemoprotein beta-component; Nitrite/sulfite reductase ferredoxin-like half domain:Nitrite and sulfite reductase iron-sulfur/siroheme-binding site:Nitrite. (552 aa)
ADZ72008.1L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (462 aa)
ADZ72253.13-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (438 aa)
queGElectron transport protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (373 aa)
miaB2-methylthioadenine synthetase (MiaB-like) protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (485 aa)
Your Current Organism:
Polymorphum gilvum
NCBI taxonomy Id: 991905
Other names: P. gilvum SL003B-26A1, Polymorphum gilvum SL003B-26A1, Polymorphum gilvum str. SL003B-26A1, Polymorphum gilvum strain SL003B-26A1, proteobacterium SL003B-26A1
Server load: low (16%) [HD]