STRINGSTRING
purH purH glyA-3 glyA-3 purU purU ADZ69341.1 ADZ69341.1 ADZ69734.1 ADZ69734.1 ADZ69735.1 ADZ69735.1 thyA thyA ADZ69805.1 ADZ69805.1 glyA glyA ADZ70386.1 ADZ70386.1 purN purN ADZ71094.1 ADZ71094.1 fhs fhs metF metF ADZ71200.1 ADZ71200.1 folD folD ADZ71801.1 ADZ71801.1 fmt fmt ADZ72558.1 ADZ72558.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purHIMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase. (538 aa)
glyA-3Serine hydroxymethyltransferase. (439 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
ADZ69341.15-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (198 aa)
ADZ69734.1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (304 aa)
ADZ69735.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1242 aa)
thyAPutative dihydrofolate reductase-thymidylate synthase, putative-like protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (322 aa)
ADZ69805.1Probable dihydrofolate reductase protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
glyASerine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (449 aa)
ADZ70386.1Putative 5-formyltetrahydrofolate cyclo-ligase. (252 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa)
ADZ71094.1MetFprotein-like protein; Belongs to the methylenetetrahydrofolate reductase family. (300 aa)
fhsPutative formate-tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
metFMethylenetetrahydrofolate reductase. (298 aa)
ADZ71200.1Methyltransferase protein. (318 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa)
ADZ71801.1Aminomethyltransferase. (379 aa)
fmtMethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (320 aa)
ADZ72558.1Methenyltetrahydrofolate synthetase domain-containing protein. (219 aa)
Your Current Organism:
Polymorphum gilvum
NCBI taxonomy Id: 991905
Other names: P. gilvum SL003B-26A1, Polymorphum gilvum SL003B-26A1, Polymorphum gilvum str. SL003B-26A1, Polymorphum gilvum strain SL003B-26A1, proteobacterium SL003B-26A1
Server load: low (24%) [HD]