STRINGSTRING
IL37 IL37 CD19 CD19 CD40 CD40 IL2 IL2 WDFY4 WDFY4 MCL1 MCL1 MX1 MX1 RAD50 RAD50 DDI1 DDI1 ENSCHIP00000004711 ENSCHIP00000004711 NRIP1 NRIP1 CD4 CD4 E2F3 E2F3 PCDH18 PCDH18 IL6 IL6 IFNG IFNG IL10 IL10 IL4 IL4 POLI POLI ENSCHIP00000023585 ENSCHIP00000023585 PDZD3 PDZD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL37Interleukin-1. (265 aa)
CD19CD19 molecule. (561 aa)
CD40CD40 molecule. (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
WDFY4DUF4704 domain-containing protein. (1983 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
DDI1DNA damage inducible 1 homolog 1. (459 aa)
ENSCHIP00000004711WD_REPEATS_REGION domain-containing protein. (323 aa)
NRIP1Nuclear receptor interacting protein 1. (1156 aa)
CD4CD4 molecule. (455 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
PCDH18Protocadherin 18. (1134 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IL10Interleukin 10. (177 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
POLIDNA polymerase iota. (751 aa)
ENSCHIP00000023585E2F_TDP domain-containing protein. (403 aa)
PDZD3PDZ domain containing 3. (471 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.