STRINGSTRING
STAM STAM IL1RL2 IL1RL2 GATA3 GATA3 PLCG1 PLCG1 IL2 IL2 CD28 CD28 IL1B IL1B VSIR VSIR ENSCHIP00000002948 ENSCHIP00000002948 GZMA GZMA CTLA4 CTLA4 IL17F IL17F TNF TNF IL2RA IL2RA PTPRC PTPRC CD80 CD80 IL13RA1 IL13RA1 PDCD1 PDCD1 TESPA1 TESPA1 CD4 CD4 CASP9 CASP9 IL6 IL6 REV1 REV1 MTCP1 MTCP1 NDFIP2 NDFIP2 IL1R1 IL1R1 LOC102184761 LOC102184761 LSP1 LSP1 BCL2A1 BCL2A1 FOXP3 FOXP3 MPIG6B MPIG6B TRAIP TRAIP ITGB7 ITGB7 A3GALT2 A3GALT2 RCSD1 RCSD1 IFNG IFNG IL10 IL10 CCNO CCNO IRF2 IRF2 USP4 USP4 BMF BMF CASP8AP2 CASP8AP2 IPO5 IPO5 IL22 IL22 CCR7 CCR7 IL4 IL4 IL13 IL13 TNFSF8 TNFSF8 CD27 CD27 SELL SELL KIF2C KIF2C TBX21 TBX21 IL17A IL17A CD40 CD40 IL23R IL23R CHEK2 CHEK2 NFKBID NFKBID EGR3 EGR3 PRF1 PRF1 CD40LG CD40LG IL5 IL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAMSignal transducing adaptor molecule. (534 aa)
IL1RL2Interleukin 1 receptor like 2. (552 aa)
GATA3GATA binding protein 3. (467 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
CD28CD28 molecule. (228 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
VSIRV-set immunoregulatory receptor. (312 aa)
ENSCHIP00000002948Ig-like domain-containing protein. (299 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (259 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
IL17FUncharacterized protein. (178 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL2RAInterleukin 2 receptor subunit alpha. (285 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
CD80CD80 molecule. (302 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
PDCD1Ig-like domain-containing protein. (280 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (450 aa)
CD4CD4 molecule. (455 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
NDFIP2Nedd4 family interacting protein 2. (336 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
LOC102184761Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (260 aa)
LSP1Uncharacterized protein. (362 aa)
BCL2A1BCL2 related protein A1. (175 aa)
FOXP3Forkhead box P3. (463 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (235 aa)
TRAIPTRAF interacting protein. (471 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (888 aa)
A3GALT2Alpha 1,3-galactosyltransferase 2. (358 aa)
RCSD1RCSD domain containing 1. (385 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IL10Interleukin 10. (177 aa)
CCNOCyclin O; Belongs to the cyclin family. (348 aa)
IRF2Interferon regulatory factor. (349 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
BMFBcl2 modifying factor. (184 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
IPO5Importin 5. (1097 aa)
IL22Interleukin 22. (190 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
IL13Interleukin 13. (131 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
CD27CD27 molecule. (270 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (372 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (721 aa)
TBX21T-box transcription factor 21. (533 aa)
IL17AInterleukin-17A. (153 aa)
CD40CD40 molecule. (280 aa)
IL23RInterleukin 23 receptor. (642 aa)
CHEK2Checkpoint kinase 2. (534 aa)
NFKBIDNFKB inhibitor delta. (331 aa)
EGR3Early growth response 3. (387 aa)
PRF1Perforin 1. (554 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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