STRINGSTRING
TMEM18 TMEM18 CD40 CD40 IL1B IL1B ACTL8 ACTL8 ELMOD3 ELMOD3 LOC102171899 LOC102171899 TMEM107 TMEM107 ICOS ICOS CCL21 CCL21 ENSCHIP00000004646 ENSCHIP00000004646 TMEM60 TMEM60 UBTD2 UBTD2 ARPC2 ARPC2 ENSCHIP00000003554 ENSCHIP00000003554 ACTBL2 ACTBL2 SELE SELE EEF1AKMT2 EEF1AKMT2 VMAC VMAC ENSCHIP00000001384 ENSCHIP00000001384 OTULINL OTULINL ENSCHIP00000000564 ENSCHIP00000000564 VAPA VAPA INTS10 INTS10 LOC102190981 LOC102190981 TLR2 TLR2 MELK MELK ERLIN2 ERLIN2 ACCS ACCS ZNF831 ZNF831 BCL6 BCL6 ACTG1 ACTG1 MTIF3 MTIF3 LRRC25 LRRC25 CSF2 CSF2 JAG2 JAG2 TRMT2B TRMT2B EIF2B3 EIF2B3 TNFRSF17 TNFRSF17 C18orf25 C18orf25 AKIP1 AKIP1 C1RL C1RL ACTB ACTB HLA-DRA HLA-DRA SLC9A9 SLC9A9 JAK1 JAK1 AICDA AICDA IL6 IL6 IRF7 IRF7 LOC102168811 LOC102168811 ZDHHC4 ZDHHC4 CD209 CD209 CXCL12 CXCL12 EHMT1 EHMT1 CD4 CD4 ACCSL ACCSL STAT1 STAT1 CD80 CD80 CLEC7A CLEC7A LOC102176799 LOC102176799 SDHAF3 SDHAF3 B2M B2M NSL1 NSL1 TLR3 TLR3 LOC102180084 LOC102180084 CD86 CD86 JAML JAML RSL24D1 RSL24D1 IFNG IFNG CCL5 CCL5 QTRT2 QTRT2 CXCL13 CXCL13 IL10 IL10 LOC102190717 LOC102190717 SPATA2L SPATA2L ENSCHIP00000017403 ENSCHIP00000017403 TMEM138 TMEM138 ZNF75D ZNF75D DHX36 DHX36 CD83 CD83 DENND1C DENND1C ENSCHIP00000018521 ENSCHIP00000018521 KCNN4 KCNN4 ENSCHIP00000018982 ENSCHIP00000018982 GLMP GLMP HMCES HMCES CCL19 CCL19 TLR4 TLR4 COL6A6 COL6A6 LOC102168547 LOC102168547 RPA2 RPA2 IL4 IL4 FUNDC2 FUNDC2 MYNN MYNN IL3RA IL3RA RASSF4 RASSF4 LOC106502311 LOC106502311 TIGIT TIGIT TBC1D23 TBC1D23 PSME3IP1 PSME3IP1 DSTYK DSTYK CXCR5 CXCR5 IL18 IL18 TRIB1 TRIB1 PLAC8 PLAC8 ADPGK ADPGK GAPDH GAPDH ENSCHIP00000026689 ENSCHIP00000026689 GPR107 GPR107 PCYOX1L PCYOX1L CLEC4A CLEC4A ZNF641 ZNF641 IER5 IER5 HAS1 HAS1 CD2 CD2 CD19 CD19 CCL2 CCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM18Transmembrane protein 18. (141 aa)
CD40CD40 molecule. (280 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ACTL8Actin like 8; Belongs to the actin family. (389 aa)
ELMOD3ELMO domain containing 3. (381 aa)
LOC102171899Membrane spanning 4-domains A7. (238 aa)
TMEM107Transmembrane protein 107. (140 aa)
ICOSInducible T cell costimulator. (209 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
ENSCHIP00000004646Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
TMEM60Transmembrane protein 60. (133 aa)
UBTD2Ubiquitin domain containing 2. (234 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
ENSCHIP00000003554Uncharacterized protein. (190 aa)
ACTBL2Actin beta like 2. (376 aa)
SELESelectin E. (487 aa)
EEF1AKMT2EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (236 aa)
VMACVimentin type intermediate filament associated coiled-coil protein. (166 aa)
ENSCHIP00000001384Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (237 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (365 aa)
ENSCHIP00000000564Uncharacterized protein. (276 aa)
VAPAVAMP associated protein A. (294 aa)
INTS10Integrator complex subunit 10. (736 aa)
LOC102190981SCY domain-containing protein. (109 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
MELKNon-specific serine/threonine protein kinase. (650 aa)
ERLIN2ER lipid raft associated 2. (338 aa)
ACCS1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (492 aa)
ZNF831Zinc finger protein 831. (1600 aa)
BCL6BCL6 transcription repressor. (706 aa)
ACTG1Actin gamma 1. (376 aa)
MTIF3Uncharacterized protein. (373 aa)
LRRC25Leucine rich repeat containing 25. (306 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa)
TRMT2BtRNA methyltransferase 2 homolog B. (435 aa)
EIF2B3Eukaryotic translation initiation factor 2B subunit gamma. (461 aa)
TNFRSF17TNF receptor superfamily member 17. (178 aa)
C18orf25Chromosome 18 open reading frame 25. (404 aa)
AKIP1A-kinase interacting protein 1. (201 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (484 aa)
ACTBUncharacterized protein. (375 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (641 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
IRF7Interferon regulatory factor 7. (480 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
ZDHHC4Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (343 aa)
CD209C-type lectin domain-containing protein. (315 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1293 aa)
CD4CD4 molecule. (455 aa)
ACCSL1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (611 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
CD80CD80 molecule. (302 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
SDHAF3Uncharacterized protein. (125 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
NSL1NSL1 component of MIS12 kinetochore complex. (270 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
LOC102180084Uncharacterized protein; Belongs to the actin family. (319 aa)
CD86Ig-like domain-containing protein. (289 aa)
JAMLJunction adhesion molecule like. (384 aa)
RSL24D1Ribosomal L24 domain containing 1. (163 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CCL5C-C motif chemokine. (91 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (414 aa)
CXCL13C-X-C motif chemokine. (109 aa)
IL10Interleukin 10. (177 aa)
LOC102190717SCY domain-containing protein. (112 aa)
SPATA2LSpermatogenesis associated 2 like. (409 aa)
ENSCHIP00000017403Methyltranfer_dom domain-containing protein. (159 aa)
TMEM138Transmembrane protein 138. (199 aa)
ZNF75DUncharacterized protein. (503 aa)
DHX36DEAH-box helicase 36. (1010 aa)
CD83CD83 molecule. (199 aa)
DENND1CDENN domain containing 1C. (789 aa)
ENSCHIP00000018521Uncharacterized protein. (190 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (428 aa)
ENSCHIP00000018982Uncharacterized protein. (248 aa)
GLMPGlycosylated lysosomal membrane protein. (405 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (374 aa)
CCL19C-C motif chemokine. (102 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
RPA2Replication protein A2. (270 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
FUNDC2Uncharacterized protein. (95 aa)
MYNNMyoneurin. (609 aa)
IL3RAUncharacterized protein. (510 aa)
RASSF4Ras association domain family member 4. (318 aa)
LOC106502311Uncharacterized protein. (148 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (277 aa)
TBC1D23TBC1 domain family member 23. (700 aa)
PSME3IP1Family with sequence similarity 192 member A. (251 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (928 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
PLAC8Placenta associated 8. (116 aa)
ADPGKADP dependent glucokinase. (497 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ENSCHIP00000026689Uncharacterized protein. (94 aa)
GPR107G protein-coupled receptor 107. (559 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (492 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
ZNF641Zinc finger protein 641. (424 aa)
IER5Immediate early response 5. (301 aa)
HAS1Hyaluronan synthase 1. (582 aa)
CD2CD2 molecule. (338 aa)
CD19CD19 molecule. (561 aa)
CCL2C-C motif chemokine. (98 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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