STRINGSTRING
ACOD1 ACOD1 DCSTAMP DCSTAMP CLEC4F CLEC4F SELL SELL APOE APOE ARG1 ARG1 PTPRC PTPRC GAPDH GAPDH HBEGF HBEGF CD47 CD47 CTSS CTSS CD68 CD68 ENSCHIP00000027556 ENSCHIP00000027556 CCL2 CCL2 GFAP GFAP MRC1 MRC1 IL1B IL1B ACTL8 ACTL8 IL2 IL2 LOC102179433 LOC102179433 CD36 CD36 CTSB CTSB STAT3 STAT3 IDO1 IDO1 SOST SOST SPI1 SPI1 IL4 IL4 RPA2 RPA2 IGF1 IGF1 LOC102168547 LOC102168547 TLR4 TLR4 MYD88 MYD88 C1QB C1QB B4GALT5 B4GALT5 ISG15 ISG15 SIGLEC1 SIGLEC1 OPALIN OPALIN MMP9 MMP9 IL10 IL10 HMOX1 HMOX1 CCL5 CCL5 TLR8 TLR8 LOC102179999 LOC102179999 IFNG IFNG TM4SF19 TM4SF19 RUNX2 RUNX2 CD86 CD86 LOC102180084 LOC102180084 PPARG PPARG TLR3 TLR3 CD163 CD163 HIF1A HIF1A CXCL10 CXCL10 NHP2 NHP2 TNFSF11 TNFSF11 SPP1 SPP1 MX2 MX2 ITGB2 ITGB2 LOC100860959 LOC100860959 FUOM FUOM CASP3 CASP3 CASP1 CASP1 ACTB ACTB VSIG4 VSIG4 HLA-DRA HLA-DRA JAK1 JAK1 CYBB CYBB IL6 IL6 ACE ACE TGFB1 TGFB1 CTSK CTSK LGALS3 LGALS3 TYROBP TYROBP IL1A IL1A ENSCHIP00000007681 ENSCHIP00000007681 ENSCHIP00000007424 ENSCHIP00000007424 CD4 CD4 CD207 CD207 STAT1 STAT1 LOC102176799 LOC102176799 B2M B2M ENSCHIP00000004646 ENSCHIP00000004646 TNF TNF SCARF1 SCARF1 CCRL2 CCRL2 FCAR FCAR CX3CR1 CX3CR1 LOC102175634 LOC102175634 ACTBL2 ACTBL2 XK XK MX1 MX1 BGLAP BGLAP DDX58 DDX58 TLR2 TLR2 APP APP ACTG1 ACTG1 CSF1R CSF1R LOC108633303 LOC108633303 NFATC1 NFATC1 TLR7 TLR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACOD1Aconitate decarboxylase 1. (469 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (510 aa)
CLEC4FC-type lectin domain family 4 member F. (529 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (372 aa)
APOEApolipoprotein E. (326 aa)
ARG1Arginase. (322 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CD47CD47 molecule. (321 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
CD68CD68 molecule. (335 aa)
ENSCHIP00000027556Uncharacterized protein; Belongs to the peptidase C14A family. (377 aa)
CCL2C-C motif chemokine. (98 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
MRC1Mannose receptor C-type 1. (1455 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ACTL8Actin like 8; Belongs to the actin family. (389 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
LOC102179433Ig-like domain-containing protein. (333 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (472 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (335 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IDO1Uncharacterized protein. (410 aa)
SOSTSclerostin. (212 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
RPA2Replication protein A2. (270 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
C1QBComplement C1q B chain. (247 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (388 aa)
ISG15Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1714 aa)
OPALINOligodendrocytic myelin paranodal and inner loop protein. (151 aa)
MMP9Uncharacterized protein. (709 aa)
IL10Interleukin 10. (177 aa)
HMOX1Heme oxygenase 1. (288 aa)
CCL5C-C motif chemokine. (91 aa)
TLR8TIR domain-containing protein; Belongs to the Toll-like receptor family. (1085 aa)
LOC102179999Ig-like domain-containing protein. (333 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
TM4SF19Uncharacterized protein. (202 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
CD86Ig-like domain-containing protein. (289 aa)
LOC102180084Uncharacterized protein; Belongs to the actin family. (319 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
CD163CD163 molecule. (1114 aa)
HIF1AUncharacterized protein. (823 aa)
CXCL10C-X-C motif chemokine. (102 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
SPP1Uncharacterized protein. (279 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (713 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (774 aa)
LOC100860959Uncharacterized protein; Belongs to the CD36 family. (472 aa)
FUOMFucose mutarotase. (154 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
ACTBUncharacterized protein. (375 aa)
VSIG4V-set and immunoglobulin domain containing 4. (352 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ACEAngiotensin-converting enzyme. (1313 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
LGALS3Galectin. (260 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (111 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
ENSCHIP00000007681Uncharacterized protein. (1353 aa)
ENSCHIP00000007424Uncharacterized protein. (861 aa)
CD4CD4 molecule. (455 aa)
CD207CD207 molecule. (352 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
ENSCHIP00000004646Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
FCARFc fragment of IgA receptor. (290 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC102175634Ig-like domain-containing protein. (333 aa)
ACTBL2Actin beta like 2. (376 aa)
XKXK-related protein. (444 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
DDX58DExD/H-box helicase 58. (942 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
APPAmyloid beta precursor protein. (770 aa)
ACTG1Actin gamma 1. (376 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
LOC108633303Uncharacterized protein; Belongs to the CD36 family. (473 aa)
NFATC1Nuclear factor of activated T cells 1. (1002 aa)
TLR7TIR domain-containing protein. (1054 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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