24 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	MX2	MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (713 aa)
	XK	XK-related protein. (444 aa)
	ACTBL2	Actin beta like 2. (376 aa)
	FCAR	Fc fragment of IgA receptor. (290 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	LOC102176799	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	JAK1	Tyrosine-protein kinase. (1159 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (253 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (352 aa)
	ACTB	Uncharacterized protein. (375 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
	LOC102180084	Uncharacterized protein; Belongs to the actin family. (319 aa)
	SIGLEC1	Sialic acid binding Ig like lectin 1. (1714 aa)
	B4GALT5	Beta-1,4-galactosyltransferase 5. (388 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1002 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ACTL8	Actin like 8; Belongs to the actin family. (389 aa)
	DDX58	DExD/H-box helicase 58. (942 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
	ACTG1	Actin gamma 1. (376 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSCHIP00000011080	ENSCHIP00000032903	Uncharacterized protein.	Actin gamma 1.	0.487
ACTB	CYBB	ENSCHIP00000011080	ENSCHIP00000009847	Uncharacterized protein.	Cytochrome b-245 beta chain.	0.454
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	IL1A	ENSCHIP00000011080	ENSCHIP00000007918	Uncharacterized protein.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	0.700
ACTB	JAK1	ENSCHIP00000011080	ENSCHIP00000010087	Uncharacterized protein.	Tyrosine-protein kinase.	0.746
ACTB	LOC102176799	ENSCHIP00000011080	ENSCHIP00000004827	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.937
ACTB	MX2	ENSCHIP00000011080	ENSCHIP00000012402	Uncharacterized protein.	MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.477
ACTB	NFATC1	ENSCHIP00000011080	ENSCHIP00000023403	Uncharacterized protein.	Nuclear factor of activated T cells 1.	0.708
ACTB	PPARG	ENSCHIP00000011080	ENSCHIP00000015163	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.984
ACTB	TLR2	ENSCHIP00000011080	ENSCHIP00000031619	Uncharacterized protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.793
ACTB	TLR3	ENSCHIP00000011080	ENSCHIP00000015102	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.737
ACTB	TLR4	ENSCHIP00000011080	ENSCHIP00000019512	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.879
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ACTBL2	GAPDH	ENSCHIP00000002870	ENSCHIP00000025974	Actin beta like 2.	Glyceraldehyde-3-phosphate dehydrogenase.	0.402
ACTG1	ACTB	ENSCHIP00000032903	ENSCHIP00000011080	Actin gamma 1.	Uncharacterized protein.	0.487
ACTG1	GAPDH	ENSCHIP00000032903	ENSCHIP00000025974	Actin gamma 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.685
ACTG1	LOC102176799	ENSCHIP00000032903	ENSCHIP00000004827	Actin gamma 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.580
ACTG1	PPARG	ENSCHIP00000032903	ENSCHIP00000015163	Actin gamma 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.482
ACTG1	TLR2	ENSCHIP00000032903	ENSCHIP00000031619	Actin gamma 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.468
ACTG1	TLR4	ENSCHIP00000032903	ENSCHIP00000019512	Actin gamma 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.484