STRINGSTRING
SFRP4 SFRP4 MSTO1 MSTO1 LMBRD2 LMBRD2 CNGA4 CNGA4 SLC30A2 SLC30A2 PEX26 PEX26 ITGA2 ITGA2 ERP27 ERP27 PRDM10 PRDM10 TARBP2 TARBP2 S100A5 S100A5 ADCY3 ADCY3 DEF8 DEF8 ZRANB3 ZRANB3 ELP3 ELP3 GALT GALT ST6GALNAC1 ST6GALNAC1 MFSD11 MFSD11 CALCOCO2 CALCOCO2 TAS1R1 TAS1R1 PLA2G3 PLA2G3 TMPRSS2 TMPRSS2 IL1B IL1B LOC102168592 LOC102168592 ENSCHIP00000029074 ENSCHIP00000029074 DHX35 DHX35 RNF111 RNF111 LRRTM3 LRRTM3 CSPP1 CSPP1 PTGS2 PTGS2 ATP12A ATP12A USP38 USP38 PGLYRP4 PGLYRP4 ZFYVE16 ZFYVE16 USP35 USP35 TMEM35A TMEM35A PGR PGR ZNF280D ZNF280D FBXL12 FBXL12 CLDN1 CLDN1 ESF1 ESF1 MUC2 MUC2 NIPAL3 NIPAL3 SATL1 SATL1 CARD6 CARD6 HEATR6 HEATR6 TFF1 TFF1 POF1B POF1B MSH5 MSH5 MLLT6 MLLT6 CCHCR1 CCHCR1 ATP4A ATP4A TMIGD1 TMIGD1 WDR55 WDR55 KRT8 KRT8 ENSCHIP00000019799 ENSCHIP00000019799 CKMT1A CKMT1A TMEM260 TMEM260 LGR5 LGR5 CFTR CFTR ADHFE1 ADHFE1 ENSCHIP00000018654 ENSCHIP00000018654 COG4 COG4 DENND1C DENND1C VSIG10 VSIG10 SNX7 SNX7 HDC HDC MRNIP MRNIP ENSCHIP00000016980 ENSCHIP00000016980 IL10 IL10 SAT1 SAT1 OCIAD2 OCIAD2 IFNG IFNG TTC38 TTC38 ACE2 ACE2 FAM13A FAM13A TFF3 TFF3 ZKSCAN2 ZKSCAN2 OSTC OSTC FAM83E FAM83E TMEM104 TMEM104 COLEC11 COLEC11 PGM2 PGM2 IGFBP1 IGFBP1 URGCP URGCP VIP VIP ENSCHIP00000013480 ENSCHIP00000013480 HOXA10 HOXA10 KRT14 KRT14 PTRHD1 PTRHD1 PGLYRP3 PGLYRP3 ESR1 ESR1 GTF3C6 GTF3C6 RUSC1 RUSC1 AP4E1 AP4E1 MAGI3 MAGI3 NEUROG1 NEUROG1 GAB3 GAB3 ITGA6 ITGA6 TMPRSS15 TMPRSS15 A2ML1 A2ML1 LOC102176997 LOC102176997 GAST GAST THAP1 THAP1 SOCS7 SOCS7 IL6 IL6 LOC102190476 LOC102190476 FA2H FA2H CLCA1 CLCA1 CREBRF CREBRF LOC102191387 LOC102191387 TRAPPC11 TRAPPC11 SEPSECS SEPSECS CDC42EP4 CDC42EP4 NAA25 NAA25 PPP1R14D PPP1R14D CD4 CD4 PLA2G12B PLA2G12B DCAF10 DCAF10 TOR4A TOR4A SERPINA14 SERPINA14 TRMO TRMO NHLRC2 NHLRC2 LRRC57 LRRC57 MIGA1 MIGA1 RASGRP3 RASGRP3 DENND3 DENND3 MEPCE MEPCE AHRR AHRR ELP6 ELP6 HHLA2 HHLA2 MLNR MLNR PARD3B PARD3B TMTC3 TMTC3 LOC108633784 LOC108633784 LOC102190187 LOC102190187 SST SST CNGA2 CNGA2 TM4SF20 TM4SF20 OR10J5 OR10J5 LOC102175073 LOC102175073 C14orf119 C14orf119 CLDN6 CLDN6 CLTRN CLTRN CLDN9 CLDN9 AP1AR AP1AR OCLN OCLN LOC108637674 LOC108637674 LOC102189641 LOC102189641
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP4Secreted frizzled related protein 4. (346 aa)
MSTO1Misato mitochondrial distribution and morphology regulator 1. (572 aa)
LMBRD2LMBR1 domain containing 2. (695 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
SLC30A2Solute carrier family 30 member 2. (347 aa)
PEX26Peroxisomal biogenesis factor 26. (300 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
ERP27Endoplasmic reticulum protein 27. (277 aa)
PRDM10PR/SET domain 10. (1150 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (370 aa)
S100A5Protein S100; Belongs to the S-100 family. (93 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
DEF8Differentially expressed in FDCP 8 homolog. (447 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (547 aa)
GALTGalactose-1-phosphate uridylyltransferase. (376 aa)
ST6GALNAC1ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (570 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (448 aa)
TAS1R1Taste 1 receptor member 1. (841 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
LOC102168592G_PROTEIN_RECEP_F1_2 domain-containing protein. (319 aa)
ENSCHIP00000029074Rho-GAP domain-containing protein. (205 aa)
DHX35DEAH-box helicase 35. (719 aa)
RNF111Ring finger protein 111. (986 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1193 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1074 aa)
USP38Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family. (1040 aa)
PGLYRP4Peptidoglycan recognition protein 4. (360 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1545 aa)
USP35Ubiquitin specific peptidase 35; Belongs to the peptidase C19 family. (1083 aa)
TMEM35ATransmembrane protein 35A. (177 aa)
PGRProgesterone receptor. (912 aa)
ZNF280DUncharacterized protein. (962 aa)
FBXL12F-box and leucine rich repeat protein 12. (326 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ESF1ESF1 nucleolar pre-rRNA processing protein homolog. (859 aa)
MUC2Uncharacterized protein. (906 aa)
NIPAL3NIPA like domain containing 3. (406 aa)
SATL1N-acetyltransferase domain-containing protein. (96 aa)
CARD6Caspase recruitment domain family member 6. (1033 aa)
HEATR6HEAT repeat containing 6. (1181 aa)
TFF1Trefoil factor 1. (77 aa)
POF1BPOF1B actin binding protein. (612 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (821 aa)
MLLT6MLLT6, PHD finger containing. (1094 aa)
CCHCR1Coiled-coil alpha-helical rod protein 1. (866 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1034 aa)
TMIGD1Transmembrane and immunoglobulin domain containing 1. (261 aa)
WDR55WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (382 aa)
KRT8Keratin 8; Belongs to the intermediate filament family. (484 aa)
ENSCHIP00000019799G_PROTEIN_RECEP_F1_2 domain-containing protein. (341 aa)
CKMT1AUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (416 aa)
TMEM260Transmembrane protein 260. (704 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1524 aa)
ADHFE1Fe-ADH domain-containing protein. (443 aa)
ENSCHIP00000018654G_PROTEIN_RECEP_F1_2 domain-containing protein. (285 aa)
COG4Component of oligomeric golgi complex 4. (789 aa)
DENND1CDENN domain containing 1C. (789 aa)
VSIG10V-set and immunoglobulin domain containing 10. (539 aa)
SNX7PX domain-containing protein. (471 aa)
HDCHistidine decarboxylase. (658 aa)
MRNIPMRN complex interacting protein. (361 aa)
ENSCHIP00000016980Oligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...] (73 aa)
IL10Interleukin 10. (177 aa)
SAT1Spermidine/spermine N1-acetyltransferase 1. (171 aa)
OCIAD2OCIA domain containing 2. (154 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
TTC38Tetratricopeptide repeat domain 38. (469 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
FAM13AFamily with sequence similarity 13 member A. (712 aa)
TFF3Trefoil factor 3. (81 aa)
ZKSCAN2Zinc finger with KRAB and SCAN domains 2. (968 aa)
OSTCOligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...] (149 aa)
FAM83EFamily with sequence similarity 83 member E. (494 aa)
TMEM104Transmembrane protein 104. (495 aa)
COLEC11Collectin subfamily member 11. (267 aa)
PGM2Phosphoglucomutase 2. (629 aa)
IGFBP1Insulin-like growth factor binding protein 1. (263 aa)
URGCPUpregulator of cell proliferation. (922 aa)
VIPVasoactive intestinal peptide. (170 aa)
ENSCHIP00000013480PX domain-containing protein. (325 aa)
HOXA10Homeobox A10. (413 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (514 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PGLYRP3Peptidoglycan recognition protein 3. (362 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
GTF3C6General transcription factor IIIC subunit 6. (237 aa)
RUSC1RUN and SH3 domain containing 1. (905 aa)
AP4E1Adaptor related protein complex 4 subunit epsilon 1. (1143 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1475 aa)
NEUROG1Neurogenin 1. (246 aa)
GAB3GRB2 associated binding protein 3. (587 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
TMPRSS15Transmembrane serine protease 15; Belongs to the peptidase S1 family. (1023 aa)
A2ML1Alpha-2-macroglobulin like 1. (1455 aa)
LOC102176997IF rod domain-containing protein; Belongs to the intermediate filament family. (451 aa)
GASTGastrin. (104 aa)
THAP1THAP domain containing 1. (213 aa)
SOCS7Suppressor of cytokine signaling 7. (575 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC102190476G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
CLCA1Chloride channel accessory 1. (909 aa)
CREBRFCREB3 regulatory factor. (639 aa)
LOC102191387G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa)
TRAPPC11Trafficking protein particle complex 11. (1159 aa)
SEPSECSO-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (504 aa)
CDC42EP4CDC42 effector protein 4. (348 aa)
NAA25N(alpha)-acetyltransferase 25, NatB auxiliary subunit. (972 aa)
PPP1R14DUncharacterized protein. (144 aa)
CD4CD4 molecule. (455 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
DCAF10DDB1 and CUL4 associated factor 10. (564 aa)
TOR4ATorsin family 4 member A. (406 aa)
SERPINA14SERPIN domain-containing protein; Belongs to the serpin family. (518 aa)
TRMOtRNA methyltransferase O. (436 aa)
NHLRC2NHL repeat containing 2. (726 aa)
LRRC57Uncharacterized protein. (239 aa)
MIGA1Mitoguardin 1. (687 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
DENND3DENN domain containing 3. (1297 aa)
MEPCEMethylphosphate capping enzyme. (687 aa)
AHRRUncharacterized protein. (698 aa)
ELP6Elongator acetyltransferase complex subunit 6. (266 aa)
HHLA2HERV-H LTR-associating 2. (419 aa)
MLNRMotilin receptor; Belongs to the G-protein coupled receptor 1 family. (419 aa)
PARD3BPar-3 family cell polarity regulator beta. (1037 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (918 aa)
LOC108633784Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. (104 aa)
LOC102190187G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa)
SSTSomatostatin. (116 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (663 aa)
TM4SF20Transmembrane 4 L six family member 20. (230 aa)
OR10J5Olfactory receptor family 10 subfamily J member 5. (309 aa)
LOC102175073G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa)
C14orf119Chromosome 14 open reading frame 119. (142 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CLTRNCollectrin domain-containing protein. (222 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
LOC108637674VLIG-type G domain-containing protein. (2290 aa)
LOC102189641G_PROTEIN_RECEP_F1_2 domain-containing protein. (312 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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