STRINGSTRING
KLK8 KLK8 CCDC198 CCDC198 ASPH ASPH TMEM98 TMEM98 KCNH7 KCNH7 MYO7A MYO7A ENSCHIP00000032932 ENSCHIP00000032932 ACTG1 ACTG1 ERP27 ERP27 BOK BOK NOL4 NOL4 AEN AEN OCLN OCLN CLTRN CLTRN MX1 MX1 LOC108636634 LOC108636634 ABI2 ABI2 ENSCHIP00000001384 ENSCHIP00000001384 LOC108633243 LOC108633243 LOC102186417 LOC102186417 LOC102175101 LOC102175101 ELAVL3 ELAVL3 CLDN3 CLDN3 CLDN4 CLDN4 RB1 RB1 HRAS HRAS CCDC122 CCDC122 CDKN1A CDKN1A ACTBL2 ACTBL2 CDK2 CDK2 DIP2A DIP2A FGFR3 FGFR3 APEH APEH ARPC2 ARPC2 LOC102182592 LOC102182592 ENSCHIP00000003851 ENSCHIP00000003851 ESS2 ESS2 TNKS TNKS LOC108636544 LOC108636544 C1GALT1C1 C1GALT1C1 TNF TNF UPK2 UPK2 JAK3 JAK3 PRIMA1 PRIMA1 SCNN1A SCNN1A ENSCHIP00000005465 ENSCHIP00000005465 LOC102177223 LOC102177223 CDC14C CDC14C LOC102175177 LOC102175177 TM9SF2 TM9SF2 LOC108636629 LOC108636629 VCPIP1 VCPIP1 ENSCHIP00000006560 ENSCHIP00000006560 LOC102181867 LOC102181867 GPRC5A GPRC5A LOC102178896 LOC102178896 CCND1 CCND1 NOVA2 NOVA2 TAS2R38 TAS2R38 PPP1R14D PPP1R14D TWNK TWNK ELF3 ELF3 THBD THBD LOC102168811 LOC102168811 NR1I2 NR1I2 ACSBG1 ACSBG1 TDRD9 TDRD9 GRPR GRPR LOC102189208 LOC102189208 PCDH17 PCDH17 CLVS1 CLVS1 TMEM158 TMEM158 IL6 IL6 LOC108636632 LOC108636632 S100A2 S100A2 DNAJB3 DNAJB3 SENP8 SENP8 TMEM156 TMEM156 DNAJB7 DNAJB7 PSMB8 PSMB8 LOC102174032 LOC102174032 KIAA1143 KIAA1143 LOC102181595 LOC102181595 WDR89 WDR89 ACTB ACTB COQ7 COQ7 CCDC171 CCDC171 PHTF2 PHTF2 FAM151A FAM151A ESR1 ESR1 YBX1 YBX1 ENSCHIP00000012559 ENSCHIP00000012559 SAMD13 SAMD13 NYAP1 NYAP1 FBXO28 FBXO28 NSUN7 NSUN7 F5 F5 CDH5 CDH5 FMNL3 FMNL3 HEMK1 HEMK1 ANGPT1 ANGPT1 NDRG1 NDRG1 SCN5A SCN5A ICAM1 ICAM1 LOC102180084 LOC102180084 KPNA6 KPNA6 XPO4 XPO4 BCL2 BCL2 ACE2 ACE2 OVN OVN CCNT2 CCNT2 MALT1 MALT1 MLC1 MLC1 MAK16 MAK16 ALG9 ALG9 TJP1 TJP1 RPS6KA5 RPS6KA5 HECTD2 HECTD2 UPK3A UPK3A ANKS4B ANKS4B MIER1 MIER1 ADAMTSL5 ADAMTSL5 DNAJB6 DNAJB6 ENDOU ENDOU SNAI3 SNAI3 RIPK2 RIPK2 DNAJB8 DNAJB8 NOVA1 NOVA1 ALB ALB PECAM1 PECAM1 TM4SF18 TM4SF18 MTMR1 MTMR1 LOC102168924 LOC102168924 ATOH7 ATOH7 F3 F3 CLDN5 CLDN5 TFF1 TFF1 TRIB3 TRIB3 EGFR EGFR PPFIBP2 PPFIBP2 ENSCHIP00000022899 ENSCHIP00000022899 ENSCHIP00000022996 ENSCHIP00000022996 SLC46A1 SLC46A1 MUC2 MUC2 NT5C3A NT5C3A CLDN1 CLDN1 BRCA2 BRCA2 EXOC5 EXOC5 ARID4A ARID4A PCSK2 PCSK2 CHIA CHIA STK11 STK11 ANXA5 ANXA5 LOC102174895 LOC102174895 BARX2 BARX2 ATR ATR PROCA1 PROCA1 AGXT2 AGXT2 SIGIRR SIGIRR KRCC1 KRCC1 MOB1A MOB1A NRAS NRAS LOXL4 LOXL4 SPAG9 SPAG9 SDHAF2 SDHAF2 NUP88 NUP88 THAP10 THAP10 NTN5 NTN5 POLE4 POLE4 TMPRSS2 TMPRSS2 PIGV PIGV ACTL8 ACTL8 CBLC CBLC TP53 TP53 LOC102188768 LOC102188768 ST3GAL3 ST3GAL3 LYVE1 LYVE1 TRRAP TRRAP CTNNB1 CTNNB1 LOC102173901 LOC102173901 SALL2 SALL2 ADAMTS13 ADAMTS13 DNM2 DNM2 LIMA1 LIMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (268 aa)
CCDC198Coiled-coil domain containing 198. (292 aa)
ASPHAspartate beta-hydroxylase. (752 aa)
TMEM98Transmembrane protein 98. (226 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1172 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2201 aa)
ENSCHIP00000032932ULP_PROTEASE domain-containing protein. (195 aa)
ACTG1Actin gamma 1. (376 aa)
ERP27Endoplasmic reticulum protein 27. (277 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
NOL4Nucleolar protein 4. (639 aa)
AENApoptosis enhancing nuclease. (327 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLTRNCollectrin domain-containing protein. (222 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
LOC108636634Uncharacterized protein. (186 aa)
ABI2Abl interactor 2. (475 aa)
ENSCHIP00000001384Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (237 aa)
LOC108633243Uncharacterized protein. (186 aa)
LOC102186417CSD_1 domain-containing protein. (312 aa)
LOC102175101ULP_PROTEASE domain-containing protein. (212 aa)
ELAVL3ELAV-like protein; Belongs to the RRM elav family. (364 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
RB1RB transcriptional corepressor 1. (931 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCDC122Coiled-coil domain containing 122. (275 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
ACTBL2Actin beta like 2. (376 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
DIP2ADisco interacting protein 2 homolog A. (1512 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
APEHAcylaminoacyl-peptide hydrolase. (730 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
LOC102182592ULP_PROTEASE domain-containing protein. (212 aa)
ENSCHIP00000003851Uncharacterized protein. (629 aa)
ESS2Ess-2 splicing factor homolog. (480 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
LOC108636544Uncharacterized protein. (186 aa)
C1GALT1C1Uncharacterized protein. (318 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
UPK2Uroplakin 2. (185 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
PRIMA1Proline rich membrane anchor 1. (153 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (672 aa)
ENSCHIP00000005465Uncharacterized protein. (168 aa)
LOC102177223Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (428 aa)
CDC14CCell division cycle 14C. (485 aa)
LOC102175177Uncharacterized protein. (740 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (661 aa)
LOC108636629Uncharacterized protein. (186 aa)
VCPIP1Valosin containing protein interacting protein 1. (1223 aa)
ENSCHIP00000006560NTR domain-containing protein. (240 aa)
LOC102181867Uncharacterized protein. (186 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
LOC102178896Uncharacterized protein. (318 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
NOVA2NOVA alternative splicing regulator 2. (550 aa)
TAS2R38Taste receptor type 2. (335 aa)
PPP1R14DUncharacterized protein. (144 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
ELF3E74 like ETS transcription factor 3. (372 aa)
THBDThrombomodulin. (578 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (450 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (765 aa)
TDRD9Tudor domain containing 9. (1375 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
LOC102189208Uncharacterized protein. (168 aa)
PCDH17Protocadherin 17. (1189 aa)
CLVS1Clavesin 1. (354 aa)
TMEM158Transmembrane protein 158 (gene/pseudogene). (291 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
LOC108636632Uncharacterized protein. (186 aa)
S100A2Protein S100; Belongs to the S-100 family. (98 aa)
DNAJB3J domain-containing protein. (242 aa)
SENP8ULP_PROTEASE domain-containing protein. (212 aa)
TMEM156Transmembrane protein 156. (313 aa)
DNAJB7DnaJ heat shock protein family (Hsp40) member B7. (249 aa)
PSMB8Proteasome subunit beta. (276 aa)
LOC102174032ULP_PROTEASE domain-containing protein. (212 aa)
KIAA1143KIAA1143. (156 aa)
LOC102181595Uncharacterized protein. (186 aa)
WDR89WD repeat domain 89. (386 aa)
ACTBUncharacterized protein. (375 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
CCDC171Coiled-coil domain containing 171. (1333 aa)
PHTF2Putative homeodomain transcription factor 2. (765 aa)
FAM151AUncharacterized protein. (586 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
ENSCHIP00000012559Protein MAK16 homolog; Belongs to the MAK16 family. (253 aa)
SAMD13J domain-containing protein. (222 aa)
NYAP1Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (843 aa)
FBXO28F-box domain-containing protein. (368 aa)
NSUN7NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (698 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2112 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
FMNL3Formin like 3. (1028 aa)
HEMK1HemK methyltransferase family member 1. (330 aa)
ANGPT1Angiopoietin 1. (488 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
LOC102180084Uncharacterized protein; Belongs to the actin family. (319 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (536 aa)
XPO4Exportin 4. (1150 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
OVNGlyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (539 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (725 aa)
MALT1MALT1 paracaspase. (830 aa)
MLC1Modulator of VRAC current 1. (378 aa)
MAK16Protein MAK16 homolog; Belongs to the MAK16 family. (298 aa)
ALG9Mannosyltransferase. (611 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1766 aa)
RPS6KA5Ribosomal protein S6 kinase. (827 aa)
HECTD2HECT domain E3 ubiquitin protein ligase 2. (746 aa)
UPK3AUroplakin 3A. (287 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (412 aa)
MIER1MIER1 transcriptional regulator. (527 aa)
ADAMTSL5Uncharacterized protein. (256 aa)
DNAJB6J domain-containing protein. (259 aa)
ENDOUUncharacterized protein. (413 aa)
SNAI3Snail family transcriptional repressor 3. (291 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
DNAJB8DnaJ heat shock protein family (Hsp40) member B8. (229 aa)
NOVA1NOVA alternative splicing regulator 1. (507 aa)
ALBSerum albumin. (608 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
TM4SF18Transmembrane 4 L six family member 18. (201 aa)
MTMR1Myotubularin related protein 1. (691 aa)
LOC102168924F-box domain-containing protein. (368 aa)
ATOH7Atonal bHLH transcription factor 7. (145 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
TFF1Trefoil factor 1. (77 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
PPFIBP2PPFIA binding protein 2. (987 aa)
ENSCHIP00000022899Uncharacterized protein. (536 aa)
ENSCHIP00000022996Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (484 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
MUC2Uncharacterized protein. (906 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
EXOC5Exocyst complex component 5. (694 aa)
ARID4AAT-rich interaction domain 4A. (1257 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2. (505 aa)
CHIAChitinase acidic; Belongs to the glycosyl hydrolase 18 family. (472 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
ANXA5Annexin. (334 aa)
LOC102174895Uncharacterized protein. (735 aa)
BARX2BARX homeobox 2. (278 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
PROCA1Protein interacting with cyclin A1. (378 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
SIGIRRSingle Ig and TIR domain containing. (408 aa)
KRCC1Lysine rich coiled-coil 1. (265 aa)
MOB1AMOB kinase activator 1A. (219 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOXL4Lysyl oxidase like 4. (757 aa)
SPAG9Sperm associated antigen 9. (1334 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
NUP88Uncharacterized protein. (755 aa)
THAP10Uncharacterized protein. (148 aa)
NTN5Netrin 5. (489 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
PIGVGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa)
ACTL8Actin like 8; Belongs to the actin family. (389 aa)
CBLCCbl proto-oncogene C. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
LOC102188768Uncharacterized protein. (588 aa)
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (374 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (322 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3881 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC102173901SMB domain-containing protein. (368 aa)
SALL2Spalt like transcription factor 2. (1003 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13. (1409 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
LIMA1LIM domain and actin binding 1. (760 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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