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| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | FANCI | FA complementation group I. (1086 aa) |
| | FANCA | FA complementation group A. (1416 aa) |
| | ENSCHIP00000002303 | Uncharacterized protein. (84 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1332 aa) |
| | FANCF | FA complementation group F. (359 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa) |
| | ENSCHIP00000003676 | RECA_2 domain-containing protein. (278 aa) |
| | POLK | DNA polymerase kappa. (905 aa) |
| | FSBP | Uncharacterized protein. (909 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (948 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | MLH3 | MutL homolog 3. (1463 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1194 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | POLH | DNA polymerase eta. (733 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (195 aa) |
| | RECQL4 | RecQ like helicase 4. (1176 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ENSCHIP00000007999 | Uncharacterized protein. (233 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | POLD4 | Uncharacterized protein. (132 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | ENSCHIP00000009163 | Uncharacterized protein. (122 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (637 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (195 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa) |
| | ENSCHIP00000010204 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | RMI1 | RecQ mediated genome instability 1. (624 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (889 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (932 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | POLQ | DNA polymerase theta. (2587 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (931 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (893 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | ENSCHIP00000012571 | Uncharacterized protein. (386 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1190 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) |
| | DSCC1 | Uncharacterized protein. (388 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | RAD51B | RAD51 paralog B. (270 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | CDC45 | Cell division cycle 45. (524 aa) |
| | FANCM | FA complementation group M. (2043 aa) |
| | RAD51C | RAD51 paralog C. (371 aa) |
| | RAD1 | Uncharacterized protein. (279 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1056 aa) |
| | DDX11 | DEAD/H-box helicase 11. (928 aa) |
| | FANCB | Uncharacterized protein. (447 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | ENSCHIP00000015450 | BRCT domain-containing protein. (152 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (580 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (642 aa) |
| | ENSCHIP00000015808 | BRCT domain-containing protein. (262 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | TM4SF19 | Uncharacterized protein. (202 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1894 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (887 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1752 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (877 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1124 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (851 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa) |
| | POLD1 | DNA polymerase. (1115 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | FAAP100 | FA core complex associated protein 100. (879 aa) |
| | FANCL | RING-type domain-containing protein. (379 aa) |
| | CETN2 | Centrin 2. (166 aa) |
| | UVSSA | UV stimulated scaffold protein A. (663 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (1061 aa) |
| | RFC1 | Replication factor C subunit 1. (1143 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (821 aa) |
| | POLI | DNA polymerase iota. (751 aa) |
| | TDRD3 | Tudor domain containing 3. (762 aa) |
| | RAD54L | RAD54 like. (749 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (147 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (709 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | FAAP20 | Uncharacterized protein. (192 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa) |
| | BIVM | Uncharacterized protein. (502 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa) |
| | FAAP24 | FA core complex associated protein 24. (215 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3405 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa) |
| | RMI2 | Uncharacterized protein. (161 aa) |
| | ORC2 | Origin recognition complex subunit 2. (596 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (775 aa) |
| | FANCG | FA complementation group G. (616 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (900 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3134 aa) |
| | CLSPN | Claspin. (1339 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | POLD3 | Uncharacterized protein. (464 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (131 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | FANCE | FA complementation group E. (444 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | ATRIP | ATR interacting protein. (791 aa) |
| | ENSCHIP00000029183 | Uncharacterized protein. (373 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (520 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa) |
| | PRIM2 | Uncharacterized protein. (219 aa) |
| | ENSCHIP00000031621 | Uncharacterized protein. (159 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | MSH4 | MutS homolog 4. (930 aa) |
| | LIG1 | DNA ligase. (915 aa) |
| | ENSCHIP00000032340 | NTF2 domain-containing protein. (107 aa) |
| | FANCD2 | FA complementation group D2. (1423 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
