37 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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	TDO2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
	TPH2	Tryptophan hydroxylase 2. (491 aa)
	ASMT	Uncharacterized protein. (345 aa)
	HPD	4-hydroxyphenylpyruvate dioxygenase. (389 aa)
	FAHD1	Fumarylacetoacetate hydrolase domain containing 1. (224 aa)
	HPDL	4-hydroxyphenylpyruvate dioxygenase like. (390 aa)
	QDPR	Quinoid dihydropteridine reductase. (242 aa)
	FAH	Fumarylacetoacetase. (419 aa)
	DDC	Dopa decarboxylase. (519 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (703 aa)
	KYAT1	Aminotran_1_2 domain-containing protein. (425 aa)
	AANAT	N-acetyltransferase domain-containing protein. (207 aa)
	ENSCHIP00000018237	PKcGMP_CC domain-containing protein. (119 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	PAH	Phenylalanine hydroxylase. (466 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	IDO1	Uncharacterized protein. (410 aa)
	KYAT3	Kynurenine aminotransferase 3. (476 aa)
	PCBD1	Pterin-4 alpha-carbinolamine dehydratase 1. (104 aa)
	AANAT-2	N-acetyltransferase domain-containing protein. (207 aa)
	HPS4	Uncharacterized protein. (436 aa)
	ENSCHIP00000024573	Uncharacterized protein. (60 aa)
	TPH1	Tryptophan hydroxylase 1. (444 aa)
	PCBD2	Pterin-4 alpha-carbinolamine dehydratase 2. (130 aa)
	ENSCHIP00000028513	Uncharacterized protein. (129 aa)
	SPR	Sepiapterin reductase. (267 aa)
	ENSCHIP00000029515	Uncharacterized protein. (96 aa)
	AADAT	Aminotran_1_2 domain-containing protein. (425 aa)
	LOC108634131	Uncharacterized protein. (125 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (407 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa)
	ACCS	1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (492 aa)
	HGD	Homogentisate 1,2-dioxygenase. (445 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
	GCHFR	GTP cyclohydrolase I feedback regulator. (85 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAT	ACMSD	ENSCHIP00000030168	ENSCHIP00000021624	Aminotran_1_2 domain-containing protein.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.483
AADAT	AFMID	ENSCHIP00000030168	ENSCHIP00000032933	Aminotran_1_2 domain-containing protein.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.944
AADAT	HAAO	ENSCHIP00000030168	ENSCHIP00000012374	Aminotran_1_2 domain-containing protein.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.731
AADAT	HPD	ENSCHIP00000030168	ENSCHIP00000003214	Aminotran_1_2 domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.406
AADAT	KMO	ENSCHIP00000030168	ENSCHIP00000019044	Aminotran_1_2 domain-containing protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.974
AADAT	KYAT1	ENSCHIP00000030168	ENSCHIP00000015233	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.931
AADAT	KYAT3	ENSCHIP00000030168	ENSCHIP00000021831	Aminotran_1_2 domain-containing protein.	Kynurenine aminotransferase 3.	0.938
AADAT	KYNU	ENSCHIP00000030168	ENSCHIP00000031339	Aminotran_1_2 domain-containing protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.947
AADAT	QDPR	ENSCHIP00000030168	ENSCHIP00000006722	Aminotran_1_2 domain-containing protein.	Quinoid dihydropteridine reductase.	0.679
AADAT	TDO2	ENSCHIP00000030168	ENSCHIP00000000917	Aminotran_1_2 domain-containing protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.425
AANAT	AANAT-2	ENSCHIP00000017360	ENSCHIP00000023852	N-acetyltransferase domain-containing protein.	N-acetyltransferase domain-containing protein.	0.900
AANAT	ASMT	ENSCHIP00000017360	ENSCHIP00000002997	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.992
AANAT	DDC	ENSCHIP00000017360	ENSCHIP00000011590	N-acetyltransferase domain-containing protein.	Dopa decarboxylase.	0.947
AANAT	IDO1	ENSCHIP00000017360	ENSCHIP00000021645	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.922
AANAT	IDO2	ENSCHIP00000017360	ENSCHIP00000030433	N-acetyltransferase domain-containing protein.	Indoleamine 2,3-dioxygenase 2.	0.925
AANAT	TPH1	ENSCHIP00000017360	ENSCHIP00000025378	N-acetyltransferase domain-containing protein.	Tryptophan hydroxylase 1.	0.549
AANAT	TPH2	ENSCHIP00000017360	ENSCHIP00000001570	N-acetyltransferase domain-containing protein.	Tryptophan hydroxylase 2.	0.406
AANAT-2	AANAT	ENSCHIP00000023852	ENSCHIP00000017360	N-acetyltransferase domain-containing protein.	N-acetyltransferase domain-containing protein.	0.900
AANAT-2	ASMT	ENSCHIP00000023852	ENSCHIP00000002997	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.992
AANAT-2	DDC	ENSCHIP00000023852	ENSCHIP00000011590	N-acetyltransferase domain-containing protein.	Dopa decarboxylase.	0.947