11 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	TOP3B	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa)
	BLM	BLM RecQ like helicase. (1429 aa)
	RMI1	RecQ mediated genome instability 1. (624 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
	FANCM	FA complementation group M. (2043 aa)
	RPA2	Replication protein A2. (270 aa)
	TDRD3	Tudor domain containing 3. (762 aa)
	RMI2	Uncharacterized protein. (161 aa)
	RPA3	Uncharacterized protein. (121 aa)
	ENSCHIP00000031621	Uncharacterized protein. (159 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	ENSCHIP00000031621	ENSCHIP00000006552	ENSCHIP00000031621	BLM RecQ like helicase.	Uncharacterized protein.	0.983
BLM	FANCM	ENSCHIP00000006552	ENSCHIP00000013958	BLM RecQ like helicase.	FA complementation group M.	0.999
BLM	RMI1	ENSCHIP00000006552	ENSCHIP00000010399	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.999
BLM	RMI2	ENSCHIP00000006552	ENSCHIP00000024473	BLM RecQ like helicase.	Uncharacterized protein.	0.983
BLM	RPA1	ENSCHIP00000006552	ENSCHIP00000032279	BLM RecQ like helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.997
BLM	RPA2	ENSCHIP00000006552	ENSCHIP00000020251	BLM RecQ like helicase.	Replication protein A2.	0.973
BLM	RPA3	ENSCHIP00000006552	ENSCHIP00000027638	BLM RecQ like helicase.	Uncharacterized protein.	0.990
BLM	TDRD3	ENSCHIP00000006552	ENSCHIP00000021807	BLM RecQ like helicase.	Tudor domain containing 3.	0.787
BLM	TOP3A	ENSCHIP00000006552	ENSCHIP00000012443	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
BLM	TOP3B	ENSCHIP00000006552	ENSCHIP00000000086	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.962
ENSCHIP00000031621	BLM	ENSCHIP00000031621	ENSCHIP00000006552	Uncharacterized protein.	BLM RecQ like helicase.	0.983
ENSCHIP00000031621	FANCM	ENSCHIP00000031621	ENSCHIP00000013958	Uncharacterized protein.	FA complementation group M.	0.998
ENSCHIP00000031621	RMI1	ENSCHIP00000031621	ENSCHIP00000010399	Uncharacterized protein.	RecQ mediated genome instability 1.	0.993
ENSCHIP00000031621	RMI2	ENSCHIP00000031621	ENSCHIP00000024473	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSCHIP00000031621	RPA1	ENSCHIP00000031621	ENSCHIP00000032279	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.947
ENSCHIP00000031621	RPA2	ENSCHIP00000031621	ENSCHIP00000020251	Uncharacterized protein.	Replication protein A2.	0.927
ENSCHIP00000031621	RPA3	ENSCHIP00000031621	ENSCHIP00000027638	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSCHIP00000031621	TDRD3	ENSCHIP00000031621	ENSCHIP00000021807	Uncharacterized protein.	Tudor domain containing 3.	0.801
ENSCHIP00000031621	TOP3A	ENSCHIP00000031621	ENSCHIP00000012443	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.984
ENSCHIP00000031621	TOP3B	ENSCHIP00000031621	ENSCHIP00000000086	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.947