STRINGSTRING
POLE POLE RFC2 RFC2 FEN1 FEN1 POLD2 POLD2 POLD4 POLD4 RFC3 RFC3 PCNA PCNA POLA1 POLA1 ATAD5 ATAD5 RFC5 RFC5 WDHD1 WDHD1 POLD1 POLD1 DNA2 DNA2 RFC1 RFC1 POLE3 POLE3 RFC4 RFC4 POLA2 POLA2 POLD3 POLD3 POLE4 POLE4 POLE2 POLE2 PRIM2 PRIM2 LIG1 LIG1 PRIM1 PRIM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
RFC2Replication factor C subunit 2. (352 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
POLD4Uncharacterized protein. (132 aa)
RFC3Replication factor C subunit 3. (356 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLA1DNA polymerase. (1468 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
RFC5Replication factor C subunit 5. (339 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1124 aa)
POLD1DNA polymerase. (1115 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
RFC1Replication factor C subunit 1. (1143 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
RFC4Replication factor C subunit 4. (364 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
POLD3Uncharacterized protein. (464 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
PRIM2Uncharacterized protein. (219 aa)
LIG1DNA ligase. (915 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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