STRINGSTRING
YES1 YES1 IRS4 IRS4 IRS2 IRS2 GRAP GRAP PAG1 PAG1 PIK3R2 PIK3R2 CRKL CRKL RABIF RABIF CBL CBL FYN FYN CRK CRK RASGRP1 RASGRP1 PIK3CG PIK3CG SHC3 SHC3 INS INS VAV1 VAV1 DOK3 DOK3 SYK SYK ZAP70 ZAP70 SHC1 SHC1 KHDRBS1 KHDRBS1 TXK TXK SHC4 SHC4 SRMS SRMS INSR INSR PTPN22 PTPN22 MATK MATK GRAP2 GRAP2 PDPK1 PDPK1 FGR FGR PIK3R3 PIK3R3 GRB2 GRB2 VAV3 VAV3 PIK3CA PIK3CA FER FER RAPGEF1 RAPGEF1 PLCG2 PLCG2 BLNK BLNK GAB2 GAB2 TIAM1 TIAM1 PTPN1 PTPN1 SOS1 SOS1 PTPN11 PTPN11 PIK3CB PIK3CB BCR BCR INSRR INSRR PIK3CD PIK3CD LCP2 LCP2 ELMO1 ELMO1 SHC2 SHC2 PIK3R1 PIK3R1 BTK BTK RAC3 RAC3 PIK3R5 PIK3R5 ABL1 ABL1 HCK HCK VAV2 VAV2 GRB10 GRB10 LYN LYN DOCK2 DOCK2 CSK CSK NRAS NRAS AKT1 AKT1 PLEK2 PLEK2 IGF1R IGF1R LOC106504022 LOC106504022 GAB1 GAB1 PLCG1 PLCG1 PIK3R6 PIK3R6 LAT LAT PTK6 PTK6 SOS2 SOS2 PTK2B PTK2B DOK1 DOK1 BCAR1 BCAR1 ITK ITK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YES1Tyrosine-protein kinase. (541 aa)
IRS4Insulin receptor substrate 4. (1213 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
GRAPUncharacterized protein. (217 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (434 aa)
PIK3R2Uncharacterized protein. (724 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
RABIFRAB interacting factor. (123 aa)
CBLCbl proto-oncogene. (932 aa)
FYNTyrosine-protein kinase. (537 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
SHC3SHC adaptor protein 3. (592 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
VAV1Vav guanine nucleotide exchange factor 1. (844 aa)
DOK3Docking protein 3. (435 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
ZAP70Tyrosine-protein kinase. (622 aa)
SHC1SHC adaptor protein 1. (583 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (443 aa)
TXKTyrosine-protein kinase. (527 aa)
SHC4SHC adaptor protein 4. (630 aa)
SRMSTyrosine-protein kinase. (494 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (795 aa)
MATKTyrosine-protein kinase. (485 aa)
GRAP2GRB2 related adaptor protein 2. (318 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
FGRTyrosine-protein kinase. (527 aa)
PIK3R3Uncharacterized protein. (461 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1077 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
BLNKB cell linker. (384 aa)
GAB2GRB2 associated binding protein 2. (680 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BCRBCR activator of RhoGEF and GTPase. (1130 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LCP2Lymphocyte cytosolic protein 2. (527 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
SHC2Uncharacterized protein. (565 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BTKTyrosine-protein kinase. (658 aa)
RAC3Rac family small GTPase 3. (192 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (898 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
HCKTyrosine-protein kinase. (528 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
GRB10Growth factor receptor bound protein 10. (591 aa)
LYNTyrosine-protein kinase. (512 aa)
DOCK2DHR-1 domain-containing protein; Belongs to the DOCK family. (846 aa)
CSKTyrosine-protein kinase. (450 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PLEK2Pleckstrin 2. (354 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC106504022Uncharacterized protein. (553 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1296 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (762 aa)
LATLinker for activation of T cells. (246 aa)
PTK6Tyrosine-protein kinase. (450 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
DOK1Docking protein 1. (483 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (848 aa)
ITKTyrosine-protein kinase. (619 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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