STRINGSTRING
MAPK1 MAPK1 ENSCHIP00000000726 ENSCHIP00000000726 MAPK14 MAPK14 FOSB FOSB JUN JUN GPS2 GPS2 RORC RORC ENSCHIP00000003195 ENSCHIP00000003195 HSPB6 HSPB6 JUNB JUNB IER2 IER2 TBL1X TBL1X MAPK8IP2 MAPK8IP2 CARM1 CARM1 DUSP7 DUSP7 ARNTL ARNTL CREB3L1 CREB3L1 PML PML NFIL3 NFIL3 MAP3K4 MAP3K4 NR4A1 NR4A1 NCOR2 NCOR2 NCOR1 NCOR1 PRKD3 PRKD3 RXRB RXRB FOSL2 FOSL2 CEBPD CEBPD TBL1XR1 TBL1XR1 NCOA2 NCOA2 SIRT1 SIRT1 THRA THRA DUSP4 DUSP4 ATF2 ATF2 CEBPA CEBPA ESR2 ESR2 DUSP16 DUSP16 GADD45B GADD45B RARB RARB ENSCHIP00000008932 ENSCHIP00000008932 CSNK1D CSNK1D FBXL3 FBXL3 MAPK10 MAPK10 ARNT ARNT DUSP9 DUSP9 KLF5 KLF5 SP1 SP1 DUSP5 DUSP5 FOXO4 FOXO4 ENSCHIP00000010840 ENSCHIP00000010840 PER1 PER1 MAPK4 MAPK4 EGR4 EGR4 SRA1 SRA1 PTPN7 PTPN7 NR1H3 NR1H3 NR1D2 NR1D2 PPARD PPARD SIK2 SIK2 MAPK7 MAPK7 MAPKAPK3 MAPKAPK3 MAPK9 MAPK9 MAPKAPK5 MAPKAPK5 ESR1 ESR1 RUNX1T1 RUNX1T1 IER3 IER3 MAP2K3 MAP2K3 BHLHE40 BHLHE40 RARA RARA MAP2K2 MAP2K2 PRMT1 PRMT1 HIF1A HIF1A ENSCHIP00000014888 ENSCHIP00000014888 MAPK8IP1 MAPK8IP1 HSPB1 HSPB1 TEF TEF CREB3L2 CREB3L2 MAPK3 MAPK3 MAPK12 MAPK12 GADD45G GADD45G NCOA1 NCOA1 ATF1 ATF1 CLOCK CLOCK JDP2 JDP2 RPS6KA5 RPS6KA5 CREM CREM NR1D1 NR1D1 CREBBP CREBBP PRKD1 PRKD1 CREB5 CREB5 EP300 EP300 NCOA3 NCOA3 FOXO1 FOXO1 FOXO3 FOXO3 CRTC3 CRTC3 MAPK11 MAPK11 EGR2 EGR2 PTPN3 PTPN3 NAB2 NAB2 AHR AHR ARNTL2 ARNTL2 SPI1 SPI1 NPAS4 NPAS4 NR4A3 NR4A3 ATF6B ATF6B DUSP10 DUSP10 CRTC1 CRTC1 MAPK8IP3 MAPK8IP3 AKIRIN2 AKIRIN2 ENSCHIP00000023179 ENSCHIP00000023179 PRKD2 PRKD2 MAP2K1 MAP2K1 MAP2K7 MAP2K7 DUSP1 DUSP1 ZC3H12A ZC3H12A ENSCHIP00000025113 ENSCHIP00000025113 MAP2K5 MAP2K5 FABP5 FABP5 THRB THRB NHLRC1 NHLRC1 DBP DBP NAB1 NAB1 ENSCHIP00000025627 ENSCHIP00000025627 PER3 PER3 ARNT2 ARNT2 EGR3 EGR3 EGR1 EGR1 PTPRR PTPRR FOSL1 FOSL1 LOC102180576 LOC102180576 EPM2A EPM2A CRTC2 CRTC2 ZFP36 ZFP36 SMCO2 SMCO2 NPAS2 NPAS2 PRXL2C PRXL2C RARG RARG MAPK13 MAPK13 CRY2 CRY2 HDAC3 HDAC3 PER2 PER2 MAP3K5 MAP3K5 RXRA RXRA BHLHE41 BHLHE41 SIM2 SIM2 MAP2K6 MAP2K6 FOS FOS GADD45A GADD45A MAPK8 MAPK8 MAP2K4 MAP2K4 RORB RORB RORA RORA ATF7 ATF7 DUSP2 DUSP2 PPFIBP1 PPFIBP1 CREB3L3 CREB3L3 MAP3K1 MAP3K1 MAPK6 MAPK6 NFKBIZ NFKBIZ RXRG RXRG TBPL2 TBPL2 MAPKAPK2 MAPKAPK2 CRY1 CRY1 ZNF565 ZNF565 CREB1 CREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
ENSCHIP00000000726Protein kinase domain-containing protein. (176 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
GPS2G protein pathway suppressor 2. (327 aa)
RORCRAR related orphan receptor C. (508 aa)
ENSCHIP00000003195C2H2-type domain-containing protein. (126 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (164 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
IER2Immediate early response 2. (224 aa)
TBL1XUncharacterized protein. (528 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (822 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (632 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
PMLPromyelocytic leukemia. (868 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1590 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (623 aa)
NCOR2Nuclear receptor corepressor 2. (2479 aa)
NCOR1Nuclear receptor corepressor 1. (2447 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
RXRBRetinoid X receptor beta. (533 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
CEBPDCCAAT/enhancer-binding protein. (256 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (520 aa)
NCOA2Nuclear receptor coactivator. (1473 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
THRAThyroid hormone receptor alpha. (511 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CEBPACCAAT enhancer binding protein alpha. (353 aa)
ESR2Uncharacterized protein. (527 aa)
DUSP16Dual specificity phosphatase 16. (643 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RARBRetinoic acid receptor beta. (448 aa)
ENSCHIP00000008932Uncharacterized protein. (166 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
FBXL3F-box and leucine rich repeat protein 3. (429 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (768 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (380 aa)
KLF5Uncharacterized protein. (454 aa)
SP1Uncharacterized protein. (786 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (465 aa)
FOXO4Forkhead box O4. (535 aa)
ENSCHIP00000010840Uncharacterized protein. (85 aa)
PER1Period circadian regulator 1. (1289 aa)
MAPK4Mitogen-activated protein kinase 4. (588 aa)
EGR4Early growth response 4. (482 aa)
SRA1Steroid receptor RNA activator 1. (261 aa)
PTPN7Protein tyrosine phosphatase non-receptor type 7. (340 aa)
NR1H3Uncharacterized protein. (447 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (578 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SIK2Salt inducible kinase 2. (907 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (780 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPKAPK5Protein kinase domain-containing protein. (431 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (603 aa)
IER3Immediate early response 3. (156 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (349 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
RARARetinoic acid receptor alpha. (462 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
HIF1AUncharacterized protein. (823 aa)
ENSCHIP00000014888IRF tryptophan pentad repeat domain-containing protein. (244 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (714 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
TEFTEF transcription factor, PAR bZIP family member. (303 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK12Mitogen-activated protein kinase 12. (359 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ATF1Activating transcription factor 1. (310 aa)
CLOCKClock circadian regulator. (845 aa)
JDP2Jun dimerization protein 2. (163 aa)
RPS6KA5Ribosomal protein S6 kinase. (827 aa)
CREMUncharacterized protein. (362 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (616 aa)
CREBBPCREB binding protein. (2435 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
CREB5cAMP responsive element binding protein 5. (549 aa)
EP300E1A binding protein p300. (2411 aa)
NCOA3Nuclear receptor coactivator. (1471 aa)
FOXO1Forkhead box O1. (668 aa)
FOXO3Forkhead box O3. (672 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
MAPK11Mitogen-activated protein kinase. (417 aa)
EGR2Early growth response 2. (472 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (905 aa)
NAB2NGFI-A binding protein 2. (525 aa)
AHRUncharacterized protein. (842 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (584 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
NPAS4Neuronal PAS domain protein 4. (801 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (648 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CRTC1CREB regulated transcription coactivator 1. (629 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1301 aa)
AKIRIN2Akirin 2. (222 aa)
ENSCHIP00000023179Uncharacterized protein. (330 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (558 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
ENSCHIP00000025113PAS domain-containing protein. (954 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (463 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
THRBThyroid hormone receptor beta. (476 aa)
NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa)
DBPD-box binding PAR bZIP transcription factor. (325 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ENSCHIP00000025627Uncharacterized protein. (125 aa)
PER3Period circadian regulator 3. (1155 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
EGR3Early growth response 3. (387 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (659 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
LOC102180576Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
CRTC2CREB regulated transcription coactivator 2. (706 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
SMCO2Uncharacterized protein. (318 aa)
NPAS2Neuronal PAS domain protein 2. (817 aa)
PRXL2CPeroxiredoxin like 2C. (228 aa)
RARGRetinoic acid receptor gamma. (458 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CRY2Cryptochrome circadian regulator 2. (596 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
PER2Period circadian regulator 2. (1269 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
RXRANR LBD domain-containing protein. (106 aa)
BHLHE41Basic helix-loop-helix family member e41. (487 aa)
SIM2SIM bHLH transcription factor 2. (672 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (344 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (412 aa)
RORBRAR related orphan receptor B. (468 aa)
RORAUncharacterized protein. (527 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (313 aa)
PPFIBP1PPFIA binding protein 1. (1033 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
NFKBIZMolecule possessing ankyrin-repeats induced by lipopolysaccharide. (719 aa)
RXRGRetinoid X receptor gamma. (539 aa)
TBPL2TATA-box binding protein like 2. (357 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (410 aa)
CRY1Cryptochrome circadian regulator 1. (593 aa)
ZNF565Zinc finger protein 565. (494 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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