(63 nodes) Neurotransmitter secretion, and Neurotransmitter loading into synaptic vesicle network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108635390	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (574 aa)
	SYTL4	Synaptotagmin like 4. (670 aa)
	CPLX3	Complexin 3. (158 aa)
	STX19	Syntaxin 19; Belongs to the syntaxin family. (294 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
	STX11	Syntaxin 11; Belongs to the syntaxin family. (287 aa)
	LOC108636029	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	RAB3A	RAB3A, member RAS oncogene family. (228 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1194 aa)
	RIMBP2	RIMS binding protein 2. (1275 aa)
	SYT7	Synaptotagmin 7. (687 aa)
	SYN1	Synapsin I. (708 aa)
	SLC18A3	Solute carrier family 18 member A3. (524 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	SLC32A1	Solute carrier family 32 member 1. (526 aa)
	UNC13A	Unc-13 homolog A. (1730 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1678 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	ENSCHIP00000008890	Uncharacterized protein. (281 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
	CPLX1	Complexin 1. (150 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (201 aa)
	UNC13B	Unc-13 homolog B. (1612 aa)
	VAMP3	Vesicle associated membrane protein 3. (104 aa)
	UNC13C	Uncharacterized protein. (1170 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (296 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1441 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
	VAMP1	Vesicle associated membrane protein 1. (116 aa)
	RAB3D	RAB3D, member RAS oncogene family. (219 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (208 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	SYNGR3	Synaptogyrin. (229 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (834 aa)
	SLC17A7	Solute carrier family 17 member 7. (560 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	SLC17A8	Solute carrier family 17 member 8. (589 aa)
	SYNGR1	Synaptogyrin. (234 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	STXBP2	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (588 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	ENSCHIP00000020058	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (559 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	MPP6	Membrane palmitoylated protein 6; Belongs to the MAGUK family. (554 aa)
	SYN3	Synapsin III. (339 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	MYRIP	Myosin VIIA and Rab interacting protein. (854 aa)
	MYO5A	Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1896 aa)
	SLC18A1	Solute carrier family 18 member A1. (538 aa)
	CPLX4	Complexin 4. (160 aa)
	ENSCHIP00000024754	L27_1 domain-containing protein. (61 aa)
	RPH3A	Rabphilin 3A. (700 aa)
	SYT2	Synaptotagmin 2. (417 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	SNAP47	Synaptosome associated protein 47. (420 aa)
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (552 aa)
	CPLX2	Complexin 2. (134 aa)
	SYNPR	Synaptoporin. (265 aa)
	VAMP5	Vesicle associated membrane protein 5. (117 aa)
	SYT1	Synaptotagmin 1. (441 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	CASK	ENSCHIP00000016720	ENSCHIP00000014579	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.990
APBA1	ENSCHIP00000020058	ENSCHIP00000016720	ENSCHIP00000020058	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.466
APBA1	LIN7A	ENSCHIP00000016720	ENSCHIP00000001581	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.766
APBA1	LIN7B	ENSCHIP00000016720	ENSCHIP00000020081	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.711
APBA1	LIN7C	ENSCHIP00000016720	ENSCHIP00000009784	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.711
APBA1	LOC108635390	ENSCHIP00000016720	ENSCHIP00000000028	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.466
APBA1	MPP1	ENSCHIP00000016720	ENSCHIP00000012784	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 1; Belongs to the MAGUK family.	0.779
APBA1	MPP2	ENSCHIP00000016720	ENSCHIP00000031608	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 2; Belongs to the MAGUK family.	0.698
APBA1	MPP6	ENSCHIP00000016720	ENSCHIP00000020299	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 6; Belongs to the MAGUK family.	0.698
APBA1	PPFIA3	ENSCHIP00000016720	ENSCHIP00000004159	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 3.	0.476
APBA1	RIMS1	ENSCHIP00000016720	ENSCHIP00000007704	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 1.	0.429
APBA1	RIMS2	ENSCHIP00000016720	ENSCHIP00000011848	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 2.	0.740
APBA1	SLC18A3	ENSCHIP00000016720	ENSCHIP00000006489	Amyloid beta precursor protein binding family A member 1.	Solute carrier family 18 member A3.	0.436
APBA1	SNAP25	ENSCHIP00000016720	ENSCHIP00000022303	Amyloid beta precursor protein binding family A member 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.518
APBA1	STX1A	ENSCHIP00000016720	ENSCHIP00000008100	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.890
APBA1	STX1B	ENSCHIP00000016720	ENSCHIP00000016255	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1B; Belongs to the syntaxin family.	0.405
APBA1	STXBP1	ENSCHIP00000016720	ENSCHIP00000019347	Amyloid beta precursor protein binding family A member 1.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.961
APBA1	STXBP2	ENSCHIP00000016720	ENSCHIP00000019682	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.466
APBA1	SYT1	ENSCHIP00000016720	ENSCHIP00000033749	Amyloid beta precursor protein binding family A member 1.	Synaptotagmin 1.	0.482
APBA1	SYT2	ENSCHIP00000016720	ENSCHIP00000028404	Amyloid beta precursor protein binding family A member 1.	Synaptotagmin 2.	0.509