(6 nodes) Retromer, cargo-selective complex, and Intralumenal vesicle formation network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS26A	VPS26, retromer complex component A. (327 aa)
	SNX3	Sorting nexin 3. (162 aa)
	VPS29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (186 aa)
	VPS26B	VPS26, retromer complex component B. (333 aa)
	SNX27	Sorting nexin 27. (541 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SNX27	SNX3	ENSCHIP00000023595	ENSCHIP00000001709	Sorting nexin 27.	Sorting nexin 3.	0.985
SNX27	VPS26A	ENSCHIP00000023595	ENSCHIP00000000131	Sorting nexin 27.	VPS26, retromer complex component A.	0.979
SNX27	VPS26B	ENSCHIP00000023595	ENSCHIP00000018183	Sorting nexin 27.	VPS26, retromer complex component B.	0.948
SNX27	VPS29	ENSCHIP00000023595	ENSCHIP00000004307	Sorting nexin 27.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.941
SNX27	VPS35	ENSCHIP00000023595	ENSCHIP00000031637	Sorting nexin 27.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.952
SNX3	SNX27	ENSCHIP00000001709	ENSCHIP00000023595	Sorting nexin 3.	Sorting nexin 27.	0.985
SNX3	VPS26A	ENSCHIP00000001709	ENSCHIP00000000131	Sorting nexin 3.	VPS26, retromer complex component A.	0.946
SNX3	VPS26B	ENSCHIP00000001709	ENSCHIP00000018183	Sorting nexin 3.	VPS26, retromer complex component B.	0.974
SNX3	VPS29	ENSCHIP00000001709	ENSCHIP00000004307	Sorting nexin 3.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.969
SNX3	VPS35	ENSCHIP00000001709	ENSCHIP00000031637	Sorting nexin 3.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.990
VPS26A	SNX27	ENSCHIP00000000131	ENSCHIP00000023595	VPS26, retromer complex component A.	Sorting nexin 27.	0.979
VPS26A	SNX3	ENSCHIP00000000131	ENSCHIP00000001709	VPS26, retromer complex component A.	Sorting nexin 3.	0.946
VPS26A	VPS26B	ENSCHIP00000000131	ENSCHIP00000018183	VPS26, retromer complex component A.	VPS26, retromer complex component B.	0.976
VPS26A	VPS29	ENSCHIP00000000131	ENSCHIP00000004307	VPS26, retromer complex component A.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.999
VPS26A	VPS35	ENSCHIP00000000131	ENSCHIP00000031637	VPS26, retromer complex component A.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.999
VPS26B	SNX27	ENSCHIP00000018183	ENSCHIP00000023595	VPS26, retromer complex component B.	Sorting nexin 27.	0.948
VPS26B	SNX3	ENSCHIP00000018183	ENSCHIP00000001709	VPS26, retromer complex component B.	Sorting nexin 3.	0.974
VPS26B	VPS26A	ENSCHIP00000018183	ENSCHIP00000000131	VPS26, retromer complex component B.	VPS26, retromer complex component A.	0.976
VPS26B	VPS29	ENSCHIP00000018183	ENSCHIP00000004307	VPS26, retromer complex component B.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.999
VPS26B	VPS35	ENSCHIP00000018183	ENSCHIP00000031637	VPS26, retromer complex component B.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.999