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| | YY1 | YY1 transcription factor. (415 aa) |
| | HELB | DNA helicase B. (1077 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (903 aa) |
| | RCC1 | Regulator of chromosome condensation 1. (444 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (505 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1235 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa) |
| | MSH4 | MutS homolog 4. (930 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | DNMT3L | PHD-type domain-containing protein. (390 aa) |
| | ACTR6 | Actin related protein 6; Belongs to the actin family. (396 aa) |
| | SYCP3 | Synaptonemal complex protein 3. (229 aa) |
| | ENSCHIP00000031750 | SMC_N domain-containing protein. (189 aa) |
| | SETD5 | SET domain containing 5. (1439 aa) |
| | PRIM2 | Uncharacterized protein. (219 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1070 aa) |
| | HORMAD2 | HORMA domain containing 2. (306 aa) |
| | CHMP1A | Charged multivesicular body protein 1A. (247 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1711 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | BRMS1 | BRMS1 transcriptional repressor and anoikis regulator. (253 aa) |
| | CDX2 | Caudal type homeobox 2. (306 aa) |
| | TFPT | TCF3 fusion partner. (254 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | SYCE1 | Synaptonemal complex central element protein 1. (320 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | ENSCHIP00000001457 | PAPA-1 domain-containing protein. (349 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1140 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (325 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (806 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1191 aa) |
| | FIGNL1 | Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa) |
| | ENSCHIP00000002654 | Uncharacterized protein. (121 aa) |
| | NUFIP1 | Nuclear FMR1 interacting protein 1. (493 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1332 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa) |
| | FKBP6 | Peptidylprolyl isomerase. (327 aa) |
| | TREX1 | Three prime repair exonuclease 1. (315 aa) |
| | ENSCHIP00000004209 | Uncharacterized protein. (211 aa) |
| | TRIM24 | Tripartite motif containing 24. (1050 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1188 aa) |
| | MORF4L1 | Mortality factor 4 like 1. (363 aa) |
| | IK | IK cytokine. (530 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa) |
| | ZMIZ2 | Zinc finger MIZ-type containing 2. (934 aa) |
| | NEK2 | NIMA related kinase 2. (445 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (599 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | MLH3 | MutL homolog 3. (1463 aa) |
| | NCAPH2 | Non-SMC condensin II complex subunit H2. (617 aa) |
| | SYN1 | Synapsin I. (708 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | NIFK | Nucleolar protein interacting with the FHA domain of MKI67. (306 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | HSPA2 | Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] (636 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | INO80D | INO80 complex subunit D. (1026 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | CPSF6 | Cleavage and polyadenylation specific factor 6. (588 aa) |
| | HORMAD1 | HORMA domain containing 1. (377 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (615 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (789 aa) |
| | ENSCHIP00000007999 | Uncharacterized protein. (233 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1231 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | ZNHIT1 | Zinc finger HIT-type containing 1. (205 aa) |
| | TEX12 | Testis expressed 12. (123 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | EP400 | E1A binding protein p400. (3022 aa) |
| | POLD4 | Uncharacterized protein. (132 aa) |
| | NOL6 | Nucleolar protein 6. (1146 aa) |
| | SRCAP | Uncharacterized protein. (3241 aa) |
| | ENSCHIP00000009163 | Uncharacterized protein. (122 aa) |
| | ING2 | Inhibitor of growth protein. (283 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1022 aa) |
| | SUDS3 | SDS3 homolog, SIN3A corepressor complex component. (324 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa) |
| | ENSCHIP00000010002 | Uncharacterized protein. (205 aa) |
| | ENSCHIP00000010204 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | C17orf64 | Chromosome 17 open reading frame 64. (234 aa) |
| | SMARCAD1 | Uncharacterized protein. (1028 aa) |
| | ENSCHIP00000011121 | Uncharacterized protein. (167 aa) |
| | SYCP2 | Synaptonemal complex protein 2. (1456 aa) |
| | ATRX | ATRX chromatin remodeler. (2105 aa) |
| | WAPL | WAPL cohesin release factor. (1193 aa) |
| | SMARCA5 | Uncharacterized protein. (1052 aa) |
| | HMGA2 | Uncharacterized protein. (104 aa) |
| | PLRG1 | Pleiotropic regulator 1. (514 aa) |
| | SINHCAF | Uncharacterized protein. (221 aa) |
| | ENSCHIP00000012479 | Uncharacterized protein. (215 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | CCNB1IP1 | Cyclin B1 interacting protein 1. (277 aa) |
| | CDC45 | Cell division cycle 45. (524 aa) |
| | RAD1 | Uncharacterized protein. (279 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1396 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1371 aa) |
| | BCNT | Bcnt protein. (298 aa) |
| | SIN3B | SIN3 transcription regulator family member B. (1142 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | LOC108637664 | Uncharacterized protein. (1041 aa) |
| | BRMS1L | BRMS1 like transcriptional repressor. (320 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (388 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | SIRT7 | Sirtuin 7. (405 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (458 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1752 aa) |
| | RSPH1 | Radial spoke head component 1. (270 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | INO80E | INO80 complex subunit E. (241 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1124 aa) |
| | EXOSC9 | Exosome component 9. (440 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (851 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (916 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | SYCP2L | Synaptonemal complex protein 2 like. (856 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (223 aa) |
| | DHX9 | DExH-box helicase 9. (1271 aa) |
| | POLD1 | DNA polymerase. (1115 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1482 aa) |
| | MCRS1 | Microspherule protein 1. (462 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | KIFAP3 | Kinesin associated protein 3. (749 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1244 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1558 aa) |
| | SAP130 | Sin3A associated protein 130. (1057 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (1061 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (395 aa) |
| | RNF212B | Ring finger protein 212B. (300 aa) |
| | SYCP1 | Synaptonemal complex protein 1. (918 aa) |
| | PHF12 | PHD finger protein 12. (1004 aa) |
| | ADD3 | Adducin 3. (706 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (739 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (147 aa) |
| | REC8 | REC8 meiotic recombination protein. (564 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (232 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa) |
| | LRPPRC | PPR_long domain-containing protein. (1391 aa) |
| | SETX | Senataxin. (2659 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1298 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (89 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | BRD8 | Bromodomain containing 8. (1216 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3405 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa) |
| | ORC2 | Origin recognition complex subunit 2. (596 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (900 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (468 aa) |
| | CDC5L | Cell division cycle 5 like. (802 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (554 aa) |
| | LRIF1 | Ligand dependent nuclear receptor interacting factor 1. (763 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | BCAS2 | Uncharacterized protein. (225 aa) |
| | STAG3 | Stromal antigen 3. (1240 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (602 aa) |
| | SYCE2 | Synaptonemal complex central element protein 2. (138 aa) |
| | INCENP | Inner centromere protein. (873 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | POLD3 | Uncharacterized protein. (464 aa) |
| | TUBG1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (131 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) |
| | INO80B | PAPA-1 domain-containing protein. (373 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa) |
| | KMT2E | Lysine methyltransferase 2E. (1858 aa) |
