STRINGSTRING
ENSCHIP00000012960 ENSCHIP00000012960 ENSCHIP00000001595 ENSCHIP00000001595 UCHL5 UCHL5 RAD50 RAD50 APEX1 APEX1 ENSCHIP00000003676 ENSCHIP00000003676 TERT TERT SMC6 SMC6 INO80 INO80 BLM BLM INO80D INO80D ENSCHIP00000007586 ENSCHIP00000007586 UPF1 UPF1 RECQL4 RECQL4 NBN NBN ENSCHIP00000008108 ENSCHIP00000008108 LOC102188481 LOC102188481 TERF1 TERF1 NOP10 NOP10 XRCC6 XRCC6 TELO2 TELO2 YY1 YY1 PRKDC PRKDC RTEL1 RTEL1 PIF1 PIF1 POT1 POT1 WRN WRN NHP2 NHP2 RAD51C RAD51C ACTR8 ACTR8 DCLRE1C DCLRE1C WRAP53 WRAP53 ZBTB48 ZBTB48 PCNA PCNA GAR1 GAR1 PARP3 PARP3 DCLRE1A DCLRE1A LTO1 LTO1 ATM ATM ACTL6A ACTL6A SLX4 SLX4 DKC1 DKC1 SMC5 SMC5 INO80E INO80E DNA2 DNA2 MCRS1 MCRS1 RUVBL1 RUVBL1 STN1 STN1 RAD51D RAD51D RIF1 RIF1 XRCC1 XRCC1 NFRKB NFRKB XRCC3 XRCC3 SLX1A SLX1A TERF2IP TERF2IP BRCA2 BRCA2 MRE11 MRE11 FBXO4 FBXO4 ATR ATR TPRKB TPRKB XRCC5 XRCC5 ERCC4 ERCC4 CCNE2 CCNE2 ZNF827 ZNF827 TINF2 TINF2 DCLRE1B DCLRE1B HUS1 HUS1 ZNF365 ZNF365 RUVBL2 RUVBL2 TERF2 TERF2 CTC1 CTC1 TFPT TFPT CCNE1 CCNE1 ACD ACD ERCC1 ERCC1 RPA1 RPA1 PINX1 PINX1 TEP1 TEP1 RAD51 RAD51 NSMCE2 NSMCE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000012960DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (287 aa)
ENSCHIP00000001595Uncharacterized protein. (333 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (325 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
INO80INO80 complex ATPase subunit. (1566 aa)
BLMBLM RecQ like helicase. (1429 aa)
INO80DINO80 complex subunit D. (1026 aa)
ENSCHIP00000007586H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa)
UPF1UPF1 RNA helicase and ATPase. (1126 aa)
RECQL4RecQ like helicase 4. (1176 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
ENSCHIP00000008108CS domain-containing protein. (116 aa)
LOC102188481Uncharacterized protein. (379 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
TELO2Telomere maintenance 2. (825 aa)
YY1YY1 transcription factor. (415 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
POT1Protection of telomeres 1. (785 aa)
WRNWRN RecQ like helicase. (1405 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
RAD51CRAD51 paralog C. (371 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (214 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
DCLRE1ADNA cross-link repair 1A. (1051 aa)
LTO1LTO1 maturation factor of ABCE1. (137 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ACTL6AActin like 6A; Belongs to the actin family. (458 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
DKC1Dyskerin pseudouridine synthase 1. (506 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
INO80EINO80 complex subunit E. (241 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
MCRS1Microspherule protein 1. (462 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
NFRKBNuclear factor related to kappaB binding protein. (1298 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa)
TERF2IPUncharacterized protein. (400 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
FBXO4F-box protein 4. (393 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ZNF827Zinc finger protein 827. (1351 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
DCLRE1BDNA cross-link repair 1B. (542 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ZNF365Zinc finger protein 365. (406 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
TFPTTCF3 fusion partner. (254 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
TEP1Telomerase associated protein 1. (2633 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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