STRINGSTRING
THOC5 THOC5 PINX1 PINX1 CBX5 CBX5 PML PML ZBTB10 ZBTB10 ENSCHIP00000004265 ENSCHIP00000004265 RAD17 RAD17 CHD4 CHD4 TERF2IP TERF2IP BRCA2 BRCA2 WDR82 WDR82 THOC3 THOC3 ORC2 ORC2 MRE11 MRE11 XRCC5 XRCC5 LRIF1 LRIF1 RBBP7 RBBP7 ERCC4 ERCC4 ZNF827 ZNF827 TNKS TNKS TERT TERT ENSCHIP00000003676 ENSCHIP00000003676 RNF8 RNF8 EZH2 EZH2 PPP1R10 PPP1R10 RAD50 RAD50 CDK2 CDK2 RBBP4-2 RBBP4-2 HMBOX1 HMBOX1 ENSCHIP00000001595 ENSCHIP00000001595 TOX4 TOX4 SMCHD1 SMCHD1 TERB1 TERB1 SIRT6 SIRT6 ERCC1 ERCC1 NABP1 NABP1 WRAP53 WRAP53 ZBTB48 ZBTB48 GAR1 GAR1 RBBP4 RBBP4 CHEK2 CHEK2 TINF2 TINF2 ENSCHIP00000027862 ENSCHIP00000027862 DCLRE1B DCLRE1B ORC4 ORC4 ATM ATM SLX4 SLX4 TFIP11 TFIP11 GATAD2B GATAD2B DHX36 DHX36 SMC5 SMC5 THOC7 THOC7 POLD1 POLD1 RPA2 RPA2 DNA2 DNA2 XRCC1 XRCC1 STN1 STN1 RAD51D RAD51D NSMCE1 NSMCE1 LRWD1 LRWD1 RIF1 RIF1 RAD51 RAD51 CCDC155 CCDC155 NSMCE2 NSMCE2 TP53BP1 TP53BP1 BLM BLM HAT1 HAT1 SMC6 SMC6 TEN1 TEN1 KDM1A KDM1A FEN1 FEN1 POLR2B POLR2B ENSCHIP00000007586 ENSCHIP00000007586 UPF1 UPF1 SPO11 SPO11 HDAC2 HDAC2 TERF2 TERF2 CTC1 CTC1 DMC1 DMC1 CHEK1 CHEK1 ACD ACD RECQL4 RECQL4 NBN NBN SUN2 SUN2 LOC102188481 LOC102188481 TERF1 TERF1 PPP1CA PPP1CA ORC1 ORC1 TERB2 TERB2 THOC6 THOC6 ATRX ATRX PPP1CB PPP1CB ENSCHIP00000012149 ENSCHIP00000012149 RTEL1 RTEL1 WRNIP1 WRNIP1 PPP1CC PPP1CC PIF1 PIF1 POT1 POT1 WRN WRN NSMCE4A NSMCE4A NABP2 NABP2 THOC1 THOC1 DOT1L DOT1L MTA2 MTA2 TEP1 TEP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THOC5THO complex 5. (694 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
CBX5Chromobox 5. (191 aa)
PMLPromyelocytic leukemia. (868 aa)
ZBTB10Zinc finger and BTB domain containing 10. (819 aa)
ENSCHIP00000004265Uncharacterized protein. (393 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
CHD4Uncharacterized protein. (1905 aa)
TERF2IPUncharacterized protein. (400 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
WDR82WD_REPEATS_REGION domain-containing protein. (313 aa)
THOC3THO complex 3. (351 aa)
ORC2Origin recognition complex subunit 2. (596 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (763 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ZNF827Zinc finger protein 827. (1351 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (920 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
HMBOX1Homeobox containing 1. (420 aa)
ENSCHIP00000001595Uncharacterized protein. (333 aa)
TOX4TOX high mobility group box family member 4. (621 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (728 aa)
SIRT6Sirtuin 6. (335 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
NABP1Nucleic acid binding protein 1. (205 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (214 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (426 aa)
CHEK2Checkpoint kinase 2. (534 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
ENSCHIP00000027862WD_REPEATS_REGION domain-containing protein. (404 aa)
DCLRE1BDNA cross-link repair 1B. (542 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
GATAD2BGATA zinc finger domain containing 2B. (592 aa)
DHX36DEAH-box helicase 36. (1010 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
THOC7THO complex 7. (203 aa)
POLD1DNA polymerase. (1115 aa)
RPA2Replication protein A2. (270 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (739 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CCDC155Coiled-coil domain containing 155. (505 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
BLMBLM RecQ like helicase. (1429 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (413 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
TEN1Uncharacterized protein. (123 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (873 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
ENSCHIP00000007586H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa)
UPF1UPF1 RNA helicase and ATPase. (1126 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
RECQL4RecQ like helicase 4. (1176 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
SUN2Sad1 and UNC84 domain containing 2. (789 aa)
LOC102188481Uncharacterized protein. (379 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (385 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
TERB2Telomere repeat binding bouquet formation protein 2. (221 aa)
THOC6THO complex 6. (341 aa)
ATRXATRX chromatin remodeler. (2105 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ENSCHIP00000012149WD_REPEATS_REGION domain-containing protein. (289 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
WRNIP1WRN helicase interacting protein 1. (640 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (314 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
POT1Protection of telomeres 1. (785 aa)
WRNWRN RecQ like helicase. (1405 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (413 aa)
NABP2Nucleic acid binding protein 2. (175 aa)
THOC1THO complex 1. (657 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1713 aa)
MTA2Metastasis associated 1 family member 2. (654 aa)
TEP1Telomerase associated protein 1. (2633 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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