43 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	PER2	Period circadian regulator 2. (1269 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	ENSCHIP00000026945	Enolase_C domain-containing protein. (279 aa)
	PHF1	PHD finger protein 1. (567 aa)
	STK36	Serine/threonine kinase 36. (1310 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	PHF12	PHD finger protein 12. (1004 aa)
	ZNF644	Zinc finger protein 644. (1368 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (616 aa)
	HDGF	Heparin binding growth factor. (259 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
	ENO1	Enolase 1. (434 aa)
	ETS1	Uncharacterized protein. (485 aa)
	EED	Embryonic ectoderm development. (441 aa)
	ELOC	Elongin C; Belongs to the SKP1 family. (112 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	NEK6	NIMA related kinase 6; Belongs to the protein kinase superfamily. (313 aa)
	MTF2	Metal response element binding transcription factor 2. (593 aa)
	FAM89B	Family with sequence similarity 89 member B. (192 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	PER1	Period circadian regulator 1. (1289 aa)
	ENSCHIP00000009674	2-Hacid_dh domain-containing protein. (402 aa)
	HDGFL1	HDGF like 1. (238 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1293 aa)
	SIX3	SIX homeobox 3. (325 aa)
	HDAC6	Histone deacetylase 6. (988 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	LCOR	Ligand dependent nuclear receptor corepressor. (1595 aa)
	ZBTB16	Uncharacterized protein. (673 aa)
	ENSCHIP00000003997	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (111 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	THAP7	THAP domain containing 7. (308 aa)
	CTBP2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (459 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	RORA	Uncharacterized protein. (527 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (435 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (602 aa)
	PER3	Period circadian regulator 3. (1155 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (542 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CTBP1	ENSCHIP00000032540	ENSCHIP00000030551	BCL6 transcription repressor.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.485
BCL6	EZH2	ENSCHIP00000032540	ENSCHIP00000003420	BCL6 transcription repressor.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.798
BCL6	HDAC1	ENSCHIP00000032540	ENSCHIP00000022688	BCL6 transcription repressor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.813
BCL6	LEF1	ENSCHIP00000032540	ENSCHIP00000030629	BCL6 transcription repressor.	HMG box domain-containing protein.	0.469
BCL6	RUNX3	ENSCHIP00000032540	ENSCHIP00000029126	BCL6 transcription repressor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.473
BCL6	STAT1	ENSCHIP00000032540	ENSCHIP00000005767	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.650
CTBP1	BCL6	ENSCHIP00000030551	ENSCHIP00000032540	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	BCL6 transcription repressor.	0.485
CTBP1	CTBP2	ENSCHIP00000030551	ENSCHIP00000022211	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.435
CTBP1	EED	ENSCHIP00000030551	ENSCHIP00000014508	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Embryonic ectoderm development.	0.414
CTBP1	HDAC1	ENSCHIP00000030551	ENSCHIP00000022688	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.965
CTBP1	HDAC3	ENSCHIP00000030551	ENSCHIP00000027962	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
CTBP1	HDGF	ENSCHIP00000030551	ENSCHIP00000017105	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Heparin binding growth factor.	0.512
CTBP1	HDGFL1	ENSCHIP00000030551	ENSCHIP00000008486	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	HDGF like 1.	0.553
CTBP1	LCOR	ENSCHIP00000030551	ENSCHIP00000004747	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Ligand dependent nuclear receptor corepressor.	0.543
CTBP1	LEF1	ENSCHIP00000030551	ENSCHIP00000030629	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	HMG box domain-containing protein.	0.688
CTBP2	CTBP1	ENSCHIP00000022211	ENSCHIP00000030551	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.435
CTBP2	EED	ENSCHIP00000022211	ENSCHIP00000014508	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Embryonic ectoderm development.	0.411
CTBP2	HDAC1	ENSCHIP00000022211	ENSCHIP00000022688	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.640
CTBP2	HDAC3	ENSCHIP00000022211	ENSCHIP00000027962	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.436
CTBP2	LEF1	ENSCHIP00000022211	ENSCHIP00000030629	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	HMG box domain-containing protein.	0.554