(57 nodes) Vasculogenesis network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	ENG	Endoglin. (649 aa)
	FBXW7	F-box and WD repeat domain containing 7. (705 aa)
	APELA	Uncharacterized protein. (54 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	SOX18	SRY-box transcription factor 18. (393 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	TEAD2	TEA domain transcription factor 2. (448 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	GJC1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
	HOXA13	Homeobox A13. (388 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2518 aa)
	GLMN	Glomulin, FKBP associated protein. (592 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	NTRK2	Tyrosine-protein kinase receptor. (837 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	MYOCD	Myocardin. (982 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	TNNI3	Uncharacterized protein. (228 aa)
	CCM2	PID domain-containing protein. (476 aa)
	PAXIP1	PAX interacting protein 1. (1006 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (772 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	FOXF1	Forkhead box F1. (391 aa)
	RAMP2	Receptor activity modifying protein 2. (177 aa)
	TBXT	T-box transcription factor T. (435 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (433 aa)
	HAS2	Uncharacterized protein. (552 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (656 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ENSCHIP00000008932	Uncharacterized protein. (166 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	ENSCHIP00000010686	CCM2_C domain-containing protein. (440 aa)
	MYO1E	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1113 aa)
	WARS2	Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (367 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (568 aa)
	RASA1	RAS p21 protein activator 1. (1044 aa)
	ENSCHIP00000013896	Uncharacterized protein. (179 aa)
	CUL7	Cullin 7; Belongs to the cullin family. (1698 aa)
	EPHA2	EPH receptor A2. (975 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1022 aa)
	RASIP1	Ras interacting protein 1. (961 aa)
	YAP1	Yes associated protein 1. (503 aa)
	GDF2	Growth differentiation factor 2. (430 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1072 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	LOC102170800	Uncharacterized protein. (537 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APELA	APLNR	ENSCHIP00000029361	ENSCHIP00000028073	Uncharacterized protein.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.848
APLNR	APELA	ENSCHIP00000028073	ENSCHIP00000029361	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.848
APLNR	KDR	ENSCHIP00000028073	ENSCHIP00000003056	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.484
CAV1	CTNNB1	ENSCHIP00000020742	ENSCHIP00000031016	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.883
CAV1	ENG	ENSCHIP00000020742	ENSCHIP00000033223	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Endoglin.	0.452
CAV1	EPHA2	ENSCHIP00000020742	ENSCHIP00000014598	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	EPH receptor A2.	0.571
CAV1	ITGB8	ENSCHIP00000020742	ENSCHIP00000020987	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.929
CAV1	KDR	ENSCHIP00000020742	ENSCHIP00000003056	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.503
CAV1	SPRED1	ENSCHIP00000020742	ENSCHIP00000007888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 1.	0.447
CAV1	TGFB1	ENSCHIP00000020742	ENSCHIP00000008885	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.477
CCM2	GDF2	ENSCHIP00000022326	ENSCHIP00000018864	PID domain-containing protein.	Growth differentiation factor 2.	0.400
CCM2	RASA1	ENSCHIP00000022326	ENSCHIP00000012349	PID domain-containing protein.	RAS p21 protein activator 1.	0.699
CCM2	RASIP1	ENSCHIP00000022326	ENSCHIP00000016224	PID domain-containing protein.	Ras interacting protein 1.	0.749
CTNNB1	CAV1	ENSCHIP00000031016	ENSCHIP00000020742	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.883
CTNNB1	EPHA2	ENSCHIP00000031016	ENSCHIP00000014598	Catenin beta 1.	EPH receptor A2.	0.661
CTNNB1	FBXW7	ENSCHIP00000031016	ENSCHIP00000029142	Catenin beta 1.	F-box and WD repeat domain containing 7.	0.555
CTNNB1	FOXF1	ENSCHIP00000031016	ENSCHIP00000020087	Catenin beta 1.	Forkhead box F1.	0.420
CTNNB1	FZD4	ENSCHIP00000031016	ENSCHIP00000032113	Catenin beta 1.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.888
CTNNB1	HDAC7	ENSCHIP00000031016	ENSCHIP00000009920	Catenin beta 1.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.561
CTNNB1	KDR	ENSCHIP00000031016	ENSCHIP00000003056	Catenin beta 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.892