(102 nodes) Formation of primary germ layer network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	MMP14	ZnMc domain-containing protein. (584 aa)
	TBXT	T-box transcription factor T. (435 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	ATOH8	Atonal bHLH transcription factor 8. (315 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
	PAF1	Uncharacterized protein. (501 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	SRF	Serum response factor. (509 aa)
	NANOG	Homeobox domain-containing protein. (300 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	DUSP5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (465 aa)
	TBX6	T-box transcription factor 6. (437 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	LAMA3	Laminin subunit alpha 3. (3339 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	HMGA2	Uncharacterized protein. (104 aa)
	TBX19	T-box transcription factor 19. (446 aa)
	NF2	FERM domain-containing protein. (612 aa)
	EPB41L5	FERM domain-containing protein. (505 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	VTN	SMB domain-containing protein. (475 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
	EPHA2	EPH receptor A2. (975 aa)
	ENSCHIP00000015051	Uncharacterized protein. (385 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (714 aa)
	MMP9	Uncharacterized protein. (709 aa)
	KDM6B	Lysine demethylase 6B. (1685 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
	MIXL1	Mix paired-like homeobox. (233 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	ENSCHIP00000019018	Sec8_exocyst domain-containing protein. (413 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (366 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	GATA6	GATA binding protein 6. (592 aa)
	FOXF1	Forkhead box F1. (391 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3046 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	HOXA11	Homeobox A11. (317 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	TXNRD1	Thioredoxin reductase 1. (587 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	FN1	Fibronectin 1. (2478 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	LHX1	LIM homeobox 1. (406 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
	EXOC4	Uncharacterized protein. (408 aa)
	APELA	Uncharacterized protein. (54 aa)
	TLX2	T cell leukemia homeobox 2. (284 aa)
	EOMES	Eomesodermin. (701 aa)
	ETV2	ETS domain-containing protein. (153 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LAMB1	Laminin subunit beta 1. (1842 aa)
	INHBA	Inhibin beta A subunit. (425 aa)
	DUSP2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (313 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	KDM6A	Lysine demethylase 6A. (1386 aa)
	CRB2	Crumbs cell polarity complex component 2. (1275 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	ARMC5	Armadillo repeat containing 5. (939 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
	ENSCHIP00000033272	FERM domain-containing protein. (580 aa)
	MMP8	Matrix metallopeptidase 8. (470 aa)
	MMP15	Matrix metallopeptidase 15. (675 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (219 aa)
	ENSCHIP00000002282	Uncharacterized protein. (940 aa)
	ITGB4	Integrin beta. (1850 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	ENSCHIP00000005210	Uncharacterized protein. (237 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1048 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	AXIN1	Axin 1. (867 aa)
	MSGN1	Mesogenin 1. (191 aa)
	SIX2	SIX homeobox 2. (296 aa)
	LAMB3	Laminin subunit beta 3. (1172 aa)
	POFUT2	Protein O-fucosyltransferase 2. (429 aa)
	NODAL	Nodal growth differentiation factor. (346 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	BMPR1A	ENSCHIP00000006499	ENSCHIP00000000640	Axin 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.409
AXIN1	CTNNB1	ENSCHIP00000006499	ENSCHIP00000031016	Axin 1.	Catenin beta 1.	0.999
AXIN1	LEF1	ENSCHIP00000006499	ENSCHIP00000030629	Axin 1.	HMG box domain-containing protein.	0.812
AXIN1	SFRP2	ENSCHIP00000006499	ENSCHIP00000026721	Axin 1.	Secreted frizzled related protein 2.	0.469
AXIN1	SMAD3	ENSCHIP00000006499	ENSCHIP00000011729	Axin 1.	Mothers against decapentaplegic homolog.	0.409
AXIN1	WNT11	ENSCHIP00000006499	ENSCHIP00000024696	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.495
AXIN1	WNT3	ENSCHIP00000006499	ENSCHIP00000020033	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.693
AXIN1	WNT3A	ENSCHIP00000006499	ENSCHIP00000015590	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.838
AXIN1	WNT5A	ENSCHIP00000006499	ENSCHIP00000015533	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.702
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778
BMP4	BMPR1A	ENSCHIP00000023678	ENSCHIP00000000640	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP4	BMPR2	ENSCHIP00000023678	ENSCHIP00000022191	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	COL8A1	ENSCHIP00000023678	ENSCHIP00000016115	Bone morphogenetic protein 4.	Collagen type VIII alpha 1 chain.	0.515
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	ENSCHIP00000015051	ENSCHIP00000023678	ENSCHIP00000015051	Bone morphogenetic protein 4.	Uncharacterized protein.	0.475
BMP4	EOMES	ENSCHIP00000023678	ENSCHIP00000029718	Bone morphogenetic protein 4.	Eomesodermin.	0.677
BMP4	EYA1	ENSCHIP00000023678	ENSCHIP00000025106	Bone morphogenetic protein 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.574
BMP4	FOXF1	ENSCHIP00000023678	ENSCHIP00000020087	Bone morphogenetic protein 4.	Forkhead box F1.	0.621
BMP4	GATA6	ENSCHIP00000023678	ENSCHIP00000020060	Bone morphogenetic protein 4.	GATA binding protein 6.	0.773
BMP4	ITGB1	ENSCHIP00000023678	ENSCHIP00000007508	Bone morphogenetic protein 4.	Integrin beta; Belongs to the integrin beta chain family.	0.461