55 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCHIP00000000097	Med12-PQL domain-containing protein. (315 aa)
	XRCC2	X-ray repair cross complementing 2. (280 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	PAX1	Paired box 1. (443 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	KDM6A	Lysine demethylase 6A. (1386 aa)
	CRB2	Crumbs cell polarity complex component 2. (1275 aa)
	MED12	Med12 domain-containing protein. (2040 aa)
	TBXT	T-box transcription factor T. (435 aa)
	TBX18	T-box transcription factor 18. (612 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	NLE1	Notchless homolog 1. (487 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	TBX6	T-box transcription factor 6. (437 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	MEOX2	Mesenchyme homeobox 2. (303 aa)
	EPB41L5	FERM domain-containing protein. (505 aa)
	SFRP1	Secreted frizzled related protein 1. (308 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
	ABI1	Abl interactor 1. (508 aa)
	MEOX1	Mesenchyme homeobox 1. (254 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (765 aa)
	EP300	E1A binding protein p300. (2411 aa)
	TCF15	Transcription factor 15. (197 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (366 aa)
	FOXF1	Forkhead box F1. (391 aa)
	PLXNA2	Plexin A2. (1894 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	AXIN2	Axin 2. (844 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	POFUT1	Protein O-fucosyltransferase 1. (399 aa)
	LHX1	LIM homeobox 1. (406 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1321 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (380 aa)
	NKX3-1	NK3 homeobox 1. (239 aa)
	MSGN1	Mesogenin 1. (191 aa)
	PALB2	Partner and localizer of BRCA2. (1194 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	ENSCHIP00000005210	Uncharacterized protein. (237 aa)
	DLL3	Delta like canonical Notch ligand 3. (595 aa)
	FOXB1	Forkhead box B1. (325 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	PCDH8	Protocadherin 8. (1211 aa)
	TCAP	Uncharacterized protein. (167 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
	HES7	Hes family bHLH transcription factor 7. (224 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	TBX18	ENSCHIP00000031730	ENSCHIP00000009044	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	T-box transcription factor 18.	0.613
ATM	EP300	ENSCHIP00000016363	ENSCHIP00000018340	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E1A binding protein p300.	0.584
ATM	PALB2	ENSCHIP00000016363	ENSCHIP00000006272	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Partner and localizer of BRCA2.	0.932
ATM	SMAD4	ENSCHIP00000016363	ENSCHIP00000020573	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mothers against decapentaplegic homolog.	0.512
ATM	TP53	ENSCHIP00000016363	ENSCHIP00000030141	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
ATM	XRCC2	ENSCHIP00000016363	ENSCHIP00000028876	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 2.	0.760
AXIN2	BMPR1A	ENSCHIP00000022676	ENSCHIP00000000640	Axin 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.431
AXIN2	DLL1	ENSCHIP00000022676	ENSCHIP00000023056	Axin 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.521
AXIN2	LEF1	ENSCHIP00000022676	ENSCHIP00000030629	Axin 2.	HMG box domain-containing protein.	0.955
AXIN2	LRP6	ENSCHIP00000022676	ENSCHIP00000013402	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.953
AXIN2	NRARP	ENSCHIP00000022676	ENSCHIP00000006148	Axin 2.	NOTCH regulated ankyrin repeat protein.	0.425
AXIN2	SFRP1	ENSCHIP00000022676	ENSCHIP00000012579	Axin 2.	Secreted frizzled related protein 1.	0.789
AXIN2	SFRP2	ENSCHIP00000022676	ENSCHIP00000026721	Axin 2.	Secreted frizzled related protein 2.	0.727
AXIN2	SMAD4	ENSCHIP00000022676	ENSCHIP00000020573	Axin 2.	Mothers against decapentaplegic homolog.	0.490
AXIN2	TP53	ENSCHIP00000022676	ENSCHIP00000030141	Axin 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.608
AXIN2	WNT3A	ENSCHIP00000022676	ENSCHIP00000015590	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.924
AXIN2	WNT5A	ENSCHIP00000022676	ENSCHIP00000015533	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.893
BMPR1A	AXIN2	ENSCHIP00000000640	ENSCHIP00000022676	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Axin 2.	0.431
BMPR1A	EP300	ENSCHIP00000000640	ENSCHIP00000018340	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	E1A binding protein p300.	0.420
BMPR1A	LEF1	ENSCHIP00000000640	ENSCHIP00000030629	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	HMG box domain-containing protein.	0.648