(12 nodes) Microglial cell activation network (Capra hircus)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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Your Input:
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	C1QA	Complement C1q A chain. (313 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	AZU1	Azurocidin 1. (260 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (111 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (140 aa)
	AGER	Advanced glycosylation end-product specific receptor. (416 aa)
	C5AR1	Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSCHIP00000011860	ENSCHIP00000032622	Advanced glycosylation end-product specific receptor.	Amyloid beta precursor protein.	0.674
APP	AGER	ENSCHIP00000032622	ENSCHIP00000011860	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.674
APP	CX3CR1	ENSCHIP00000032622	ENSCHIP00000003586	Amyloid beta precursor protein.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.454
APP	IFNG	ENSCHIP00000032622	ENSCHIP00000016152	Amyloid beta precursor protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.442
APP	SNCA	ENSCHIP00000032622	ENSCHIP00000009503	Amyloid beta precursor protein.	Alpha-synuclein; Belongs to the synuclein family.	0.908
APP	TNF	ENSCHIP00000032622	ENSCHIP00000004561	Amyloid beta precursor protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.606
APP	TREM2	ENSCHIP00000032622	ENSCHIP00000003876	Amyloid beta precursor protein.	Triggering receptor expressed on myeloid cells 2.	0.736
C1QA	C5AR1	ENSCHIP00000029644	ENSCHIP00000015785	Complement C1q A chain.	Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.501
C1QA	CX3CR1	ENSCHIP00000029644	ENSCHIP00000003586	Complement C1q A chain.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.781
C1QA	IFNG	ENSCHIP00000029644	ENSCHIP00000016152	Complement C1q A chain.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.427
C1QA	TNF	ENSCHIP00000029644	ENSCHIP00000004561	Complement C1q A chain.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.409
C1QA	TREM2	ENSCHIP00000029644	ENSCHIP00000003876	Complement C1q A chain.	Triggering receptor expressed on myeloid cells 2.	0.906
C1QA	TYROBP	ENSCHIP00000029644	ENSCHIP00000008282	Complement C1q A chain.	TYRO protein tyrosine kinase binding protein.	0.874
C5AR1	C1QA	ENSCHIP00000015785	ENSCHIP00000029644	Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C1q A chain.	0.501
CX3CR1	APP	ENSCHIP00000003586	ENSCHIP00000032622	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Amyloid beta precursor protein.	0.454
CX3CR1	C1QA	ENSCHIP00000003586	ENSCHIP00000029644	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C1q A chain.	0.781
CX3CR1	IFNG	ENSCHIP00000003586	ENSCHIP00000016152	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.832
CX3CR1	TNF	ENSCHIP00000003586	ENSCHIP00000004561	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.793
CX3CR1	TREM2	ENSCHIP00000003586	ENSCHIP00000003876	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Triggering receptor expressed on myeloid cells 2.	0.908
CX3CR1	TYROBP	ENSCHIP00000003586	ENSCHIP00000008282	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	TYRO protein tyrosine kinase binding protein.	0.767