STRINGSTRING
JARID2 JARID2 GLI1 GLI1 EZH2 EZH2 CUL3 CUL3 ARF6 ARF6 CEBPG CEBPG HGF HGF ELK1 ELK1 CCND1 CCND1 NF1 NF1 MAN2A1 MAN2A1 ATF2 ATF2 ONECUT2 ONECUT2 TAF10 TAF10 IL6 IL6 TBX3 TBX3 FGL1 FGL1 PRKCSH PRKCSH SMAD3 SMAD3 C6orf58 C6orf58 HLX HLX ZMPSTE24 ZMPSTE24 SULF2 SULF2 RELA RELA LSR LSR NPHP3 NPHP3 HNF1B HNF1B PIK3CA PIK3CA PDX1 PDX1 PKD1 PKD1 RPGRIP1L RPGRIP1L LOC102170474 LOC102170474 RHBDD3 RHBDD3 LOC102185363 LOC102185363 HNF4A HNF4A RB1CC1 RB1CC1 HES1 HES1 HNF1A HNF1A TGFA TGFA ONECUT1 ONECUT1 PROC PROC GATA6 GATA6 SMARCB1 SMARCB1 UPF2 UPF2 PKD2 PKD2 ANXA1 ANXA1 NOTCH1 NOTCH1 SEC63 SEC63 FRZB FRZB PROX1 PROX1 SOX9 SOX9 ZIC3 ZIC3 NOTCH2 NOTCH2 COBL COBL E2F8 E2F8 E2F7 E2F7 XBP1 XBP1 MED1 MED1 SP3 SP3 AURKA AURKA PCK2 PCK2 CCDC39 CCDC39 CDK5RAP3 CDK5RAP3 CEBPB CEBPB ADA ADA NODAL NODAL ENSCHIP00000001275 ENSCHIP00000001275 JUN JUN PCK1 PCK1 GFER GFER CCDC40 CCDC40 DNAAF1 DNAAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JARID2Jumonji and AT-rich interaction domain containing 2. (1258 aa)
GLI1GLI family zinc finger 1. (1105 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CEBPGCCAAT enhancer binding protein gamma. (149 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
ELK1ETS transcription factor ELK1. (440 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
NF1Neurofibromin 1. (2848 aa)
MAN2A1Alpha-mannosidase. (1154 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ONECUT2One cut domain family member. (511 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
TBX3T-box transcription factor 3. (749 aa)
FGL1Fibrinogen like 1. (315 aa)
PRKCSHProtein kinase C substrate 80K-H. (533 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
C6orf58Chromosome 6 open reading frame 58. (343 aa)
HLXH2.0 like homeobox. (488 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SULF2Sulfatase 2. (864 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
LSRLipolysis stimulated lipoprotein receptor. (621 aa)
NPHP3TPR_REGION domain-containing protein. (1325 aa)
HNF1BHNF1 homeobox B. (558 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDX1Pancreatic and duodenal homeobox 1. (284 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
RPGRIP1LRPGRIP1 like. (1295 aa)
LOC102170474Uncharacterized protein. (238 aa)
RHBDD3Rhomboid domain containing 3. (386 aa)
LOC102185363Uncharacterized protein. (355 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (486 aa)
RB1CC1RB1 inducible coiled-coil 1. (1589 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HNF1AHNF1 homeobox A. (631 aa)
TGFATransforming growth factor alpha. (215 aa)
ONECUT1One cut domain family member. (464 aa)
PROCVitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (458 aa)
GATA6GATA binding protein 6. (592 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (395 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
ANXA1Annexin. (346 aa)
NOTCH1Notch receptor 1. (2508 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
FRZBFrizzled related protein. (325 aa)
PROX1Prospero homeobox 1. (734 aa)
SOX9SRY-box transcription factor 9. (525 aa)
ZIC3Zic family member 3. (465 aa)
NOTCH2Notch receptor 2. (2471 aa)
COBLCordon-bleu WH2 repeat protein. (1321 aa)
E2F8E2F transcription factor 8. (866 aa)
E2F7E2F transcription factor 7. (911 aa)
XBP1BZIP domain-containing protein. (261 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
SP3Sp3 transcription factor. (778 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
CCDC39Coiled-coil domain containing 39. (931 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (508 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
ADAAdenosine deaminase. (400 aa)
NODALNodal growth differentiation factor. (346 aa)
ENSCHIP00000001275Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (154 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
GFERSulfhydryl oxidase. (203 aa)
CCDC40Coiled-coil domain containing 40. (937 aa)
DNAAF1Dynein assembly factor 1, axonemal. (643 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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